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Dr. William Allen Banks

Senior Advisor

 

"In our published study in PLoS One, hydrogen water was remarkable in reversing the various changes induced by controlled cortical impact, an experimental model of traumatic brain injury."

 

EDUCATION
1972 Graduated, Bloomfield High School, Bloomfield, MO
1975 B.A., University of Missouri-St. Louis, Magna Cum Laude in Biology
1979 M.D., University of Missouri-Columbia.

TRAINING AND APPOINTMENTS
3/7 – 11/78: Medical School Surgical Research Elective with Drs. James C. Thompson and Phil L. Rayford, University of Texas Medical Branch, Galveston, TX
7/79 – 6/80: Medical Intern (Categorical Program), Tulane Affiliated Hospitals.
7/80 – 12/81: Medical Resident, Tulane Affiliated Hospitals.
1/82 – 12/82: Fellow in Endocrinology, Veterans Administration Medical Center, New Orleans.
12/82 – 12/85: Research Associate, Veterans Administration Career Development Program, VAMC New Orleans.
1/84 – 6/89: Assistant Professor, Department of Medicine, Tulane University School of Medicine.
7/89 – 6/95: Associate Professor, Department of Medicine, Tulane University School of Medicine.
7/90 – 6/95: Associate Professor, Neuroscience Training Program Tulane University School of Medicine.
1/86 – 3/98: Staff Physician, Department of Medicine, Veterans Administration Medical Center, New Orleans.
7/95 – 3/98: Professor, Department of Medicine, Tulane University School of Medicine.
7/95 – 3/98: Professor, Neuroscience Training Program, Tulane University School of Medicine.
4/96 – 3/98: Graduate Faculty, Tulane University.
4/98 – 3/2010: Staff Physician, GRECC, Veterans Affairs Medical Center, St. Louis.
4/98 – 6/10: Professor, Division of Geriatrics, Department of Internal Medicine, Saint Louis University School of Medicine.
5/99-6/10: Professor, Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine
4/04-6/10: Graduate Faculty, Saint Louis University
3/10-1/16: Associate Director of Research, GRECC, Veterans Affairs Puget Sound Health Care System, Seattle, WA
6/10-Present: Professor, Division of Gerontology and Geriatric Medicine, Department of Internal Medicine, University of Washington, Seattle, WA
12/10-Present: Adjunct Professor of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA
1/16-Present: Associate Chief of Staff Research & Development, Veterans Affairs Puget Sound Health Care System, Seattle, WA

LICENSES AND BOARD CERTIFICATIONS
Louisiana Board of Medical Examiners (1979-Present)
Missouri Board of Medical Examiners (1998-Present)
American Boards of Internal Medicine Certification (1987)
Fellow of the American College of Endocrinology (1996)
American Boards in Endocrinology, Diabetes, and Metabolism (1997-2007)
(Board eligible in Geriatrics)

AWARDS AND HONORS
Magna Cum Laude (B.A.)
Honors in Surgical Research Elective (M.D.)
VA Career Development Award (1982-5)
Musser-Burch Society (Tulane Clinical Honors Society)
American Medical Association Physician’s Recognition Award (1990-3; 1996-9)
VA Star Award (11/91)
1994 University of Missouri-St. Louis Distinguished Biology Alumni Award (single award annually)
Fellow of the International Neuropeptide Society (1994)
Fellow of the American College of Endocrinology (1996)
1998 Outstanding Young Physician Award – University of Missouri School of Medicine Medical Alumni Organization
Certificate of Appreciation, Osmangazi University, Health Science Institute, EskiÕehir, Turkey (6/98)
Visiting Professor, Department of Anatomy, School of Medicine, Showa University, Tokyo, Japan (2004-present)
Milton D. Overholser Memorial Lecturer, U of MO Alumini Assoc Annual Meeting (2004)
Masterfoods Keynote Lecturer, Society for the Study of Ingestive Behavior (2006)
The Medical Student Training in Aging Research (MSTAR) Program at University of Washington 2012 Research Mentorship Award
2014 Normal Cousins Award, Psychoneuroimmune Research Society

SOCIETY MEMBERSHIPS
University of Missouri-St. Louis Biological Society
member: 1972-75
president: 1973
vice president: 1974-75
Musser-Burch Society
American Academy for the Advancement of Science
New York Academy of Sciences
Society for Neuroscience
Society for Neuroscience-New Orleans Chapter
Member: 1983-present
President elect: 1990-91
President: 1991-92
Chair, Finance Committee: 1995-1998
International Society for Psychoneuroendocrinology
American Peptide Society (Charter Member)
International Brain Research Organization
International Behavioral Neuroscience Society (Founding Member)
International Neuropeptide Society (Charter Member)
American College of Endocrinology
American Association of Clinical Endocrinologists
Polish Thyroid Club
Southern Medical Association
Central Society for Clinical Research
American Institute of Biological Sciences
Gerontological Society of America
PsychoNeuroImmunology Research Society
American Physiological Society
International Society for NeuroVirology
American Society for Pharmacology and Experimental Therapeutics
Society for the Study of Ingestive Behavior
ADMINISTRATIVE EXPERIENCE
President, University of Missouri-St. Louis Biological Society (1973)
Vice President, University of Missouri-St. Louis Biological Society (1974)
Veterans Affairs – New Orleans Research and Development Committee
Member (7/84-6/88; 7/91-6/94)
Chairman (7/88-6/91; 7/94-6/96; 7/97-98 (6 terms))
Veterans Affairs – New Orleans Preventive Medicine Program Committee
Member (7/90-4/94)
VA New Orleans Administrative Investigations (5; Chair of 3)
Courtesy in Action Facilitator (DVA-NO) (6/91-6/94)
Chair of CIA Phase II Manual Committee (5/93)
Geriatrics Task Force (DVA-NO) (6/91)
Society for Neuroscience-New Orleans Chapter
President: 1991-2 (President-Elect and Past-President active offices)
Chair of Finance Committee (7/95-3/98)
Veterans Affairs – New Orleans Biosafety Subcommittee
Chairman (1/93-7/94; 6/97-3/98)
Veterans Affairs – New Orleans Institutional Animal Care and Use Committee
Member (7/94-6/97)
Deans Committee for Neuroscience Strategic Plan (5/95)
Local Committee Member for the 2nd International Symposium on VIP, PACAP and
Related Peptides, New Orleans, LA, October 4-7, 1995
Secretary/Treasurer, VA-NO Medical Staff (1996)
Committee for VISN 16 Clinical Guidelines for Diabetes Mellitus; Member (Feb-July, 1997)
Veterans Affairs – St. Louis Institutional Animal Care and Use Committee Member (11/98-2009) and Chair (12/98-2009)
Veterans Affairs – St. Louis Research and Development Committee Member (4/99-2010)
PsychoNeuroImmunology Research Society Council, Scientific Affairs Committee
PsychoNeuroImmunology Research Society Nominating Committee (2004) and Program Sub-committee (2004-5).
PsychoNeuroImmunology Research Society Local Organizing Committee for the 22nd Annual Scientific Meeting (Seattle, WA)
Saint Louis University Health Sciences Center Research Building Space/Core Strategies Task Force (2004-2010)
Associate Director Geriatric Research Education and Clinical Center – Research,
Veterans Affairs Puget Sound Health Care System, Seattle, WA
Veterans Affairs – Seattle BLR&D/CSR&D/RR&D Scientific Review Subcommitte #1,
primary voting member (2010-2011; Ad hoc committee 2012-2015)
Board of Directors, Seattle Institute for Biomedical and Clinical Research (nonprofit), Seattle, WA (2010 – 2016); Vice Chair (2013 – 2016)
Chair Search Committee for ACOS R&D VAPSHCS (2011-2014)
VHA GRECC Performance Measures Committee (2011-2016)
Academic Work in Progress Committee – Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington
Search Committee for Faculty, Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine (2014 – 2015)
International Committee on VIP, PACAP, and Related Peptides (2015-Present)

SCIENTIFIC ADVISORY BOARDS
EDUNN
ADLYFE
IMPEL
MHF

 

GRADUATE STUDENT THESIS AND DISSERTATION COMMITTEES
Lawrence Maness (Ph.D., 1996; Tulane)
Laura Harrison (Ph.D., 1998; Tulane)
Kerra Gergen ( Interim Advisory Committee; Ph.D.; Tulane)
Wei-hong Pan (Major Advisor; Ph.D., 1997; Tulane)
Scott Plotkin (Major Advisor; M.D. Ph.D., 1997; Tulane)
Anna Jelaso (Ph.D., 1998; Tulane)
Angela Malin (Interim Advisory Committee; Ph.D.; Tulane)
Sheryl Martin-Schild (M.D. Ph.D., Committe member to 1998; Tulane)
Madge Suzanne Linn Tinsley (Outside Member for Oral Defense; LSUMC-Shreveport;
Department of Pharmacology Ph.D. Candidate, 1998)
Tracey Bloodgood (Interim Advisory Committee; Ph.D.; Saint Louis University)
Shola Adewale (Ph.D., 2005; Saint Louis University)
Natalie Lenard (Outside Member for Research Proposal Defense; LSUMC-Shreveport;
Department of Pharmacology and Therapeutics Ph.D. Candidate, 2001)
Meghan Taylor (Ph.D., 2005; Saint Louis University)
Kevin Gamber (Ph.D., 2006; Saint Louis University)
Laura Jeager (Major Advisor; , 2007, Ph.D.; Saint Louis University)
Tulin Otamis (Adjunct Member, Ph.D, 2006; Mamara University, Istanbul)
Angela Mohnahan (Rush Medical School; Current Graduate Student)
Suman Penugonda (Ph.D., 2007; University of Missouri-Rolla)
Suneetha Mare (Ph.D., 2007; University of Missouri-Rolla)
Michelle Erickson (Ph.D., 2012; Major Advisor; Saint Louis University)
Joshua Carey (Masters Student, University of Missouri-Rolla)
Yuhang Jiang (Outside Member, University of North Carolina)
Denfong Yuan (Outside Member, University of North Carolina)
Thomas (Dong Won) Kim (Outside Examiner, Department of Anatomy, University of Otago, New Zealand)

REVIEWS FOR GRANTING AND FUNDING AGENCIES
Alzheimer’s Association
American Institute for Biological Sciences (Army Neurotox.)
Austrian Science Fund
Comitato Telethon Fondazione ONLUS (Italian Granting Agency)
CURE: Digestive Diseases Research Center (UCLA Dept. of Medicine)
Human Frontier Science Program
Israel Science Foundation
Italian Ministry for University and Research
Medical Research Council of Canada
Ministry of Science and Technology, Israel
National Institutes of Alcohol Abuse and Alcoholism: Extramural advisory board (ad hoc member)
National Institutes of Health
National Institute on Drug Abuse*
National Institute of Mental Health
National Research, Development and Innovation Office (NKFIH) – Hungary
National Science Center – Poland
National Science Foundation
Philip Morris External Research Program (via Research Management Group)
PPP Healthcare Medical Trust
Research Foundation – Flanders
Swiss National Science Foundation
Technology Transfer STW
The Netherlands Organization for Health Research and Development
University of Missouri Research Board
Veteran’s Affairs Merit Review & Bridge Funding Programs
Wellcome Trust
*Includes site visits and chairing Ad Hoc Committee.

EDITORIAL BOARDS
Current Pharmaceutical Design
Editor-in-Chief (2002-current)
Executive Editor (2001)
Guest Editor for Special Issues on BBB in Health and Disease 2001,2004,2008.
NeuroImmunoModulation (1995-2008)
Peptides: An International Journal (1998-current)
Journal of Pharmacology and Experimental Therapeutics (2000-current)
Brain, Behavior, and Immunity (2003-current)
Drug Design and Reviews – Online (Editorial Advisory Board; 2003-5)
Asian Journal of Pharmacological Sciences (2004-current)
Medicinal Chemistry (Editorial Advisory Board; 2004-current)
Current Diabetes Reviews (2004-current)
International Journal of Neuroprotection and Neuroregeneration (2004-2008)
American Journal of Neuroprotection and Neuroregeneration (2009-current)
Journal of Alzheimer’s Disease (Associate Editor; 2009-current)
Frontiers in Alzheimer’s Disease (2010-current)
Fluids and Barriers of the CNS (2010-current)
Brain Research Bulletin (2011-current)
Endocrinology (2011-2016)
Tissue Barriers (2012-current)
Experimental Biology and Medicine (Anatomy and Pathology Section; 2014-current)

AD HOC EDITORIAL AND REFEREE REVIEWS
Acta Diabetologica
Advanced Drug Delivery Reviews
Africa Journal of Pharmacy and Pharmacological Research Age
Aging Research Reviews
Alcoholism: Clinical and Experimental Research
American Chemical Society Books
American Journal of Drug Delivery
American Journal of Human Biology
American Journal of Respiratory and Cell Molecular Biology
American Journal of the Medical Sciences
American Journal of Pathology
American Journal of Physiology: Endocrine and Metabolism; Regulatory, Integrative, and Comparative Physiology; Cell Physiology
Annals of Medicine
Annals of Neurology
Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
Antiviral Research
Archives of Internal Medicine
Arthritis & Rheumatism
Arthritis Research & Therapy
Behavioral Brain Research
Biochemical Pharmacology
Biological Psychiatry
Bioorganic & Medicinal Chemistry
Biotechnic & Histochemistry
Brain, Behavior, and Immunity
Brain Research
Brain Research Bulletin
Brain Research Reviews
British Journal of Nutrition
British Journal of Psychology
Canadian Journal of Physiology and Pharmacology
(Journal canadien de physiologie et pharmacologie)
Cell Biochemistry & Function
Cellular and Molecular Neurobiology
Cellular Physiology and Biochemistry
Chimica Oggi (Chemistry Today)
Chronobiology International
Clinical Chemistry
Clinical and Experimental Neuroimmunology
Clinical Pharmacokinetics
Critical Care Medicine
Critical Reviews in Immunology
Current Aging Science
Current Alzheimer Research
Current Diabetes Reviews
Current Medicinal Chemistry
Developmental Brain Research
Diabetes
Diabetes Management
Diabetologia
Drug Design Reviews – Online
Drug Metabolism and Disposition
Endocrinology
Endocrine (formerly Endocrine Journal)
Endocrine Practice
European Journal of Neuroscience
European Neuropsychopharmacology
Experimental Brain Research
Experimental Neurology
Expert Opinion on Drug Metabolism and Toxicology
Expert Opinion on Investigational Drugs
FASEB Journal
Federal Practitioner
Fluids and Barriers of the CNS
Future Medicinal Chemistry
Future Neurology
Human and Experimental Toxicology
Glia
Hippocampus
Inflammation Research
Intensive Care Medicine
International Journal of Developmental Neuroscience
International Journal of Obesity
International Journal of Peptide and Protein Research
International Journal of Tuberculosis and Lung Disease
International Library of Diabetes & Metabolism
Journal of Alzheimer’s Disease
Journal of Applied Physiology
Journal of Cell Science
Journal of Cellular Physiology
Journal of Clinical Endocrinology and Metabolism
Journal of Clinical Investigation
Journal of Clinical Psychopharmacology
Journal of Controlled Release
Journals of Gerontology (Medical Sciences)
Journal of Histochemistry and Cytochemistry
Journal of Immunology
Journal of Infectious Diseases
Journal of Inorganic Biochemistry
Journal of Leukocyte Biology
Journal of Molecular Neuroscience
Journal of Neural Transmission
Journal of Neurochemistry
Journal of Neuroendocrinology
Journal of Neuroimmune Pharmacology
Journal of Neuroimmunology
Journal of Neuroinflammation
Journal of Neurological Sciences
Journal of Neuroscience
Journal of Neuroscience Methods
Journal of Neuroscience Research
Journal of Neurovirology
Journal of Nuclear Medicine
Journal of Pharmaceutical Sciences
Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacy and Pharmacology
Journal of Physical Anthropology
Journal of Physiology
Journal of Sleep Research
Journal of Virology
Journal of the American Geriatrics Society
Journal of the American Medical Association – Neurology
Journal of the American Medical Directors Association
Life Sciences
Medical Science Monitor
Methods and Findings in Experimental and Clinical Pharmacology
Microvascular Research
Molecular and Cellular Biochemistry (An International Journal for Chemical Biology in
Health and Disease)
Molecular and Cellular Neurosciences
Molecular and Chemical Neuropathology
Molecular Interventions
Nature Communications
Nature Medicine
Nature Reviews Neuroscience
Neurobiology of Aging (Experimental and Clinical Research)
Neurobiology of Learning and Memory
Neurochemical Research
Neurochemistry International
Neuroendocrinology
NeuroImmunoModulation
Neuropharmacology
Neuropsychopharmacology
Neuron
Neuropeptides
Neuropsychiatric Disease and Treatment
Neuroscience
Neuroscience and Biobehavioral Reviews
Neuroscience Letters
Neuroscience Research
Neurotoxicology and Teratology
New England Journal of Medicine
Nutrition
Obesity Research
Oncotarget
Peptides
Pharmaceutical Research
Pharmacogenomics
Pharmacological Research
Pharmacology and Therapeutics
Pharmacology and Toxicology
Physiology and Behavior
Physiological Research
Plos one
Proceedings of the National Academy of Sciences, U.S.A.
Proceeding of the Society for Experimental Biology and Medicine
Progress in Neurobiology
Progress in Neuro-Psychopharmacology & Biological Psychiatry
Psychoneuroendocrinology
Psychopharmacology
Regulatory Peptides
Science
Science Translational Medicine
Scientific Reports
Stroke
Therapeutic Delivery
Toxicology and Applied Pharmacology
Trends in Neurosciences (TINS)
Trends in Pharmacological Sciences

GRANT FUNDING
Active
Oxidative Dysfunction of LRP at the Blood-brain Barrier in Alzheimer’s Disease
PI: William A. Banks, MD, Agency: NIA; Type: R01; Period: March 2008-Feb 2015 (NCE)*.
The long term goal is to determine whether amyloid beta protein inhibits its own clearance from
brain by oxidizing LRP-1, its BBB efflux system. $242,000/yr. A $100,000/yr supplement was
awarded for years 2 and 3.

Polypeptide Modification for Enhanced Brain Delivery
C0-PI: Alexander Kabanov and William A. Banks; Agency: NINDS; Type: R01; Period: April
2010 to March 2015. The long term objective is to find mechanisms that will enhance
polypeptide delivery to the brain. $250,000/yr.

Mitochondrial Carbonic Anhydrases and Diabetic Blood-brain Barrier Disruption, Co-PI: Gul
Shah and William A. Banks; Agency: NIDDK; Type: RO1; Period: Feb 2011 to Jan 2015. The
long term objective is to determine the role that mitochondrial carbonic anhydrases play in
hyperglycemia-related oxidative stress in cerebrovascular pericytes and the eventual
deterioration of the blood-brain barrier in diabetes. $250,000/yr.

Sepsis Outcomes and Aging: The Role of Sleep Disruption and the Blood Brain Barrier
PI: Mark Opp Agency: NIA Type: R01 Period: 9/30/2012 – 8/31/2017. The purpose of this grant
is to examine the relationship between fragmented sleep, infection, neuroinflammation and the
physiology of blood brain barrier transport mechanisms.Dr. Banks: subcontract studies on the
BBB transport

PC100310 (Mostaghel, PI) 07/01/2013-06/30/2014 0.6 calendar Dept. of Defense
$30,000
Steroid Transport Proteins in Castration Resistant Prostate Cancer
The goal of this project is to define the expression and role of steroid transport proteins in CRPC
using both in vitro and in vivo prostate cancer models
Banks: subcontract studies for tissue uptake of steroids.

Intranasal Insulin in a Mouse Model of Alzheimer’s Disease PI: William A Banks, MD, Agency:
NIA/NINDS; Period: July 2014-June 2019. The long term goal is to determine the mechanism
by which intranasal insulin improves cognition in a mouse model of Alzheimer’s disease.
$450,000/year.

Past Funding in Last 8 years
Control of Drug Delivery to the CNS: Modulating P-glycoprotein Activity
PI: William A. Banks, M.D; Agency: Veterans Affairs; Type: Merit Review Period: 2009-2013. The long term objective is to determine the mechanisms by which neuroinflammation affects Pgp expression and activity at the blood-brain barrier.

Insulin Resistance and Impaired Cardiovascular Regulation During Pregnancy
PI: Virginia L. Brooks, Ph.D. Agency: NIH; Type: R01; Period: June 2008-May 2013. The long term goal is to determine the mechanisms by which insulin resistance contributes to hypertension in pregnancy. Subcontract: $8,200/year.

Imaging in Alzheimer’s Disease
PI: William A. Banks. Agency: Adlyfe; Type: Industry, Period: Feb 2009-Feb 2011. The goal is to determine the ability of an imaging agent directed at amyloid beta protein to cross the bloodbrain barrier. $20,000.

Polypeptide Modification for Enhanced Brain Delivery
PI: Alexander Kabanov. Agency: NINDS; Type: R01; Period: Feb 2006 to Jan 2009; NCE to Jan 2010. The long term objective is to find mechanisms that will enhance polypeptide delivery to the brain. Dr. Banks is consortium to the grant. Consortium costs: $125,000/yr (competitive renewal first submission received score at Feb 09 study section of 148 and and 20.5%)

Prion Transport Across the Blood-Brain Barrier
PI: William A. Banks, M.D. Agency: NINDS; Type: R01; Period: August 2006-Jan 2010 with
NCE to Jan 2011. The long term goal is to determine how prions enter the brain. $275,000/yr
Mechanism of Epinephrine-induced Delivery of Enzyme to the Brain
PI: William A. Banks, M.D. & William S. Sly, M.D.; Agency: Shire Pharmaceutical; Type: Industry, Period: October 2008-Sept 2010. The goal is to determine the mechanism by which epinephrine enhances the brain uptake of the enzyme PGUS in a model of lysosomal storage disease. $50,000/yr.

Nasal Delivery of Testosterone, Pregnenolone, and Progesterone
PI: William A. Banks, M.D. Agency: Mattern Pharmaceuticals AG, Type: Industry, Period: May 2006-May 2009. The long term goal is to determine whether an intranasal formulation is effective in delivering testosterone to the brain and peripheral tissues. $10,000/yr Delivery of Antisense to Brain
PI: William A. Banks, MD. Agency: EDUNN Pharmaceuticals, Type: Industry, Period: August
2007- July 2009. The long term goal is to compare the routes of administration of an antisense
for effectiveness of delivery to the brain. $30,000/yr
Blood-Brain Barrier Transport of Met-Enk in Alcoholism
PI: William A. Banks, M.D; Agency: Veterans Affairs; Type: Merit Review Period: 1992-2008.
The long term objective is to determine how BBB mechanisms act to regulate Met-Enk levels in
the brain with a major focus on isolation of the BBB transporter for Met-Enk. $125,000
Mechanisms of HIV Transport Across the BBB
PI: William A. Banks, M.D; Agency: NINDS; Type: R01 (NS41863, years 1-5); Period: Sept
2000 to Sept 2006. The long term objective is to determine the mechanisms by which the virus
HIV-1 crosses the BBB. $225,000/yr
Amyloid-Induced Cerebroendothelial Degeneration
PI: Chung Y. Hsu, M.D. (Washington University); Agency: NINDS: Type: R01 (NS40525, years
1-5); Period: Sept 2000 to Sept 2005. Dr. Banks is a collaborator and has an inter-university
consortium agreement. $25,000/yr
PTS-1 Regulation of Brain Met-Enk Levels in Alcoholism
PI: William A. Banks, M.D., Agency: NIAAA; Type: R01 (AA12743, years 1-4); Period: June
2001 to Feb 2006. The long -term objective is to determine the role of post-translational
mechanisms in addition and relative to PTS-1 in the regulation of brain Met-Enk levels.
13
$200,000/yr
Opiate Addiction and HIV-1 Induced Release of Cytokines
PI: William A. Banks, M.D. Agency: NIDA; Type: R21; Period: July 2005 to June 2007. The
long term objective is to determine the effects of opiate addiction on the release of cytokines
from brain endothelial cells. $275,000 total for both years.
Transport of Sulfamidase across the Blood-Brain Barrier
PI: William A. Banks, M.D. and William S. Sly, M.D. Agency: Sanfilippo Syndrome Medical
Research Foundation; Grant Period: Sept 2004-Sept 2005. The long-term goal is to induce the
blood-brain barrier to transport sulfamidase. $50,000 per PI.
Effect of Megace on Cytokines in Inflammatory Anorexia Model
PI: William A Banks, M.D. Par Pharmaceutical. Grant Period June 2005-June 2007. The long
term goal is to determine whether megace can improve appetite by suppressing cytokines.
$80,000/yr.

MISCELLANEOUS
Judge, University of Missouri’s Graduate Professional Council’s Research and Creative
Activities Forum, March 2004.
Audio Talk “Ingestive Peptides” for Blood-Brain Barrier Series, Abba J. Kastin, editor,
Henry Stewart Talks, London, UK
Session Chair and Local Organizing Committee, 22nd Annual Scientific Meeting,
Psychoneuroimmunology Research Society, Seattle, WA June 3-6, 2015.

PATENTS
Modulation of the Blood-Brain Barrier Transporter for Leptin
Inventor: William A. Banks, M.D.
IPN: WO 01/013935
Inventors: Vijay B. Kumar, John E. Morley, Susan A. Farr, William A. Banks
US Patent application entitled “Compositions and Methods for Enhancing Cognitive Function”
Priority 11/10/2005, Filed Nov 10, 2006 (SLU 05-028 Pr.) USPTO Serial No. PCT/US06/60782
(Inventors: W.A. Banks, Kumar and Morley) expires Nov. 10, 2026.
PCT Patent application entitled “Modulation of Blood Brain Barrier Protein Expression,” Serial
No. 60/925,820 Priority: Filed 4/23/07 (Inventors: W.A. Banks, Kumar, and Darling) expires
April 23, 2028.
Provisional Patent application entitled “Antisense Modulation of Amyloid Beta Protein
Expression” Serial No. 60/925,820 Priority: Filed 2/19/08 (Inventors: Darling, Kumar, W.A.
Banks, S. Farr, and Morley.) Expires Feb. 19, 2029.
Kabanov, A.V., Yi, X., Vinogradov, S., Banks, W. A. Amphiphilic Polymer-Protein Conjugates
and Methods of Use Thereof. U.S. Patent Application (12/488,842) filed June 22, 2009

INVITED LECTURES (SELECTED)
1. “Treatment Development Strategies for Alzheimer’s Disease” NIMH symposium,
Southampton, Bermuda, 1985.
2. “Peptide and Amino Acid Transport Mechanisms in the Central Nervous System”
symposium, Belgrade, Yugoslavia, May, 1987.
3. Drug Delivery and Pharmacy Research groups seminar, The UpJohn Company,
Kalamazoo, MI, August, 1987.
4. “Disposition and Delivery of Peptide Drugs” International FIP Satellite Symposium,
Leiden University, Leiden, The Netherlands, September, 1987.
5. Department of Pharmacology, Tulane University School of Medicine, Departmental
Seminar, March, 1988.
6. First European Conference on Biotechnology, Verona, Italy, November, 1988.
7. “Endocrine Causes of Impotence”, Grand Rounds, University Medical Center-Southern
Nevada, Las Vegas, NV, December, 1988.
8. Second Galveston International Symposium on Gastrointestinal Endocrinology:
Receptors and Post-Receptor Mechanisms (Invited Participant), Galveston, TX, April,
1989.
9. International Symposium on Circulating Regulatory Factors and Neuroendocrine
Function (Invited Speaker and Moderator), Smolenice Castle, Czechoslovakia, June,
1989.
10. Clinical Research – Pharmaceutical Products Division Seminar, Abbott Laboratories,
Abbott Park, IL, September, 1989.
11. Geriatric Conference – GRECC (Geriatrics Research, Education, and Clinical Center),
Veterans Administration Medical Center, St. Louis, MO, October, 1989.
12. “Thyroiditis”, Grand Rounds, University Medical Center-Southern Nevada, Las Vegas,
NV, Dec. 1989.
13. Pravastatin Regional Investigators’ Roundtable (Invited Participant), Los Angeles, CA,
October, 1990.
14. Fourth International Reinhardsbrunn Symposium on Circumventricular Organs;
Circumventricular Organs and Brain Fluid Environment: Molecular and Functional
15
Aspects, Leipzig, Germany, March, 1991.
15. R&D Seminar, Pharmacology Department, Smith Kline-Beecham, King of Prussia, PA,
October, 1991.
16. King’s College-London, Special Seminar-Physiology Group, Division of Biomedical
Sciences, London, England, January, 1992.
17. 13th Annual Winter Neuropeptide Conference, Invited Speaker and Session Chair,
Breckenridge, CO, February, 1992.
18. Epithelial and Blood Brain Barrier Transport Systems Symposium, Parke-Davis
Pharmaceutical Research, Ann Arbor, MI, May, 1992.
19. International Symposium on Blood Binding and Drug Transfer, Official Satellite of the
XIIth International Symposium on Medicinal Chemistry, Basel, Switzerland, September,
1992.
20. International Symposium on Drug Transport to the Brain: Concepts and Strategies,
Leiden University, Noordwijkerhout, The Netherlands, October, 1992.
21. “Cytokines and the Brain” Philippe Laudat Conference (INSERM), Le Bischenberg
Obernai, France, October, 1992.
22. 14th Annual Winter Neuropeptide Conference, Breckenridge, CO, February, 1993.
23. Molecular Mechanisms Regulating the Permeability of the Blood-Brain Barrier: An
International Workshop; Satellite Symposium of the 11th International Biophysics
Congress, Speaker and Session Moderator, Szeged, Hungary, July, 1993.
24. Research Seminar, Parke Davis Pharmaceutical Research, Ann Arbor, MI, August, 1993.
25. Colloquia Patavina on Aluminium in Chemistry, Biology, and Medicine. Padua, Italy,
September, 1993.
26. Research Seminar, Immunex, Seattle, WA, December, 1993.
27. 15th Annual Winter Neuropeptide Conference, Invited Speaker and Session Chair,
Breckenridge, CO, February, 1994.
28. 14th European Winter Conference on Brain Research, Invited Speaker and Session Co-
Chair, La Plagne, France, March, 1994.
29. 95th Annual Meeting of the American Society for Clinical Therapeutics, Molecular
16
Therapeutics session, New Orleans, LA, March, 1994.
30. Delivery Across the Blood-Brain Barrier: Strategies to Expedite Brain Drug Discovery
and Development, International Business Communications, Washington, D.C., May,
1994.
31. American Physiological Society Conference: Physiology of the Activity and Release of
Cytokines, Yale University, New Haven, Connecticut, June, 1994.
32. New Concepts of a Blood-Brain Barrier, King’s College, London, U.K., July, 1994.
33. The Physiological Society, University of Cambridge, U.K., July, 1994.
34. Neuroimmunomodulation: Stress and Immune Function, The Lovelace Institutes,
Albuquerque, NM, October, 1994.
35. Hine’s Veteran’s Affairs Medical Center Research Seminar, Hines, IL, March, 1995.
36. Neurex Research Seminar, Menlo Park, CA, March 1995.
37. XV Corso Avanzato in Chimica Farmaceutica e Seminario Nazionale per Dottorandi “E.
Duranti”, Societa Chimica Italiana, Divisione di Chimica Farmaceutica, Urbino, Italy,
July 1995.
38. Cytokines as Communication Factors Between the Immune System and the Central
Nervous System, Arcachon, France, September 1995.
39. Effective Delivery of Proteins and Peptides, International Business Communications,
Coronado, CA, September 1995.
40. 2nd International Symposium on VIP, PACAP, & Related Peptides (Local Organizing
Committee & Speaker), New Orleans, LA, October, 1995.
41. Aitken Neuroscience Institute, New York, NY, October 1995.
42. XV Congress of the Polish Society of Endocrinology, Posnan, Poland, May 1996.
43. Towards the Cause of Narcolepsy, Tysons Corner, VA, September 1996.
44. Cerebrovascular Pathology in Alzheimer’s Disease, East Rutherford, NJ, November,
1996.
45. Research Seminar, Eli Lilly and Co., Indianapolis, Indiana, January, 1997.
17
46. Satellite Broadcast (Clinical Guidelines for Diabetes Mellitus), Department of Veterans
Affairs, Birmingham, AL, June, 1997.
47. Research Seminar, Amgen, Thousand Oaks, CA, June, 1997.
48. Cytokines and the Brain, A Satellite Symposium to the Society for Neuroscience 27th
Annual Meeting, New Orleans, LA, October, 1997.
49. Research Seminar, Veterans Affairs Medical Center, Long Beach, CA, November, 1997.
50. 31st Annual Winter Conference on Brain Research, Snowbird, Utah, January, 1998.
51. Research Seminar, Pennington Research Center, Baton Rouge, LA, February, 1998.
52. Research Seminar, Department of Pharmacology and Therapeutics, Louisiana State
University School of Medicine-Shreveport, LA, February, 1998.
53. Cerebral Vascular Biology Conference 1998: Advances in the Biology of the Cerebral
Vasculature and the Blood-Brain Barrier, Speaker and Session Moderator, Gleneden
Beach, OR, March, 1998.
54. Conference, Main Speaker, Osmangazi University, Eskisehir, Turkey, June, 1998.
55. Seventeenth Summer Symposium in Molecular Biology: “Immune – Neuro – Endocrine
Interactions: Cellular and Molecular Mechanisms”, Pennsylvania State University,
University Park, PA, July, 1998.
56. Interdepartmental Immunology Seminar Program, University of Illinois, Urbana-
Champaign, IL, March, 1999.
57. Summer Neuropeptide Conference, Key West, FL, June, 1999.
58. Combined Annual Meeting of the Midwest Section American Federation for Medical
Research, Central Society for Clinical Research, Midwest Society for Pediatric Research,
and Midwest Region Society for General Internal Medicine, Chicago, IL, September,1999.
59. 52nd Annual Scientific Meeting of the Gerontological Society of America “New
Perspectives on Aging in the Post Genome Era”, Symposium organizer and speaker, San
Francisco, CA, November, 1999.
60. Pharmaceutical Sciences Graduate Program Seminar, Department of Pharmaceutical
Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NB,
February, 2000.
61. Guest Society Symposium (Psychoneuroimmunology Research Society): “Shared
Activities of Hormones and Cytokines”, Immunology 2000, Seattle, WA, May, 2000.
62. President’s Symposium: “Accomplishments in the 20th Century”,
Psychoneuroimmunology Research Society, Wilmington, NC, May, 2000.
63. Research Seminar, Amgen, Thousand Oaks, CA, June, 2000.
64. Research Seminar, Serono Pharmaceutical Research Institute, Geneva, Switzerland,
September, 2000.
65. Anorexia During Disease-From Research to Clinical Practice Symposium, Speaker and
Session Chair, Ascona, Switzerland, September, 2000.
66. Research Seminar, Department of Physiology, West Virginia University, Morgantown,
WV, October, 2000.
67. Brain Nose & Pituitary International Symposium, Session 5: Recent Progress in PACAP
Research. Waseda University, Tokyo, Japan, December, 2000.
68. Research Seminar, Department of 1st Anatomy, Showa University School of Medicine,
Tokyo, Japan, December, 2000.
69. Research Seminar, Department of Pharmacology 1, Nagasaki University School of
Medicine, Nagasaki, Japan, December, 2000.
70. Research Seminar, Department of Pharmacology and Therapeutics, Louisiana State
University School of Medicine-Shreveport, LA, March, 2001.
71. 4th International Conference on Cerebral Vascular Biology: The Blood-Brain Barrier.
King’s College, Cambridge, UK, April, 2001.
72. International Behavioral Neuroscience Society Annual Meeting, Cancun, Mexico, April,
2001.
73. 8th Annual Meeting of the Psychoneuroimmunology Research Society, Utrecht, Holland,
May, 2001.
74. First International Meeting of Asia Minor Branch of the International Neuropeptide
Society, Antalya, Turkey, May, 2001.
75. 61st Annual Meeting and Scientific Sessions of the American Diabetes Association,
Symposium: “Central Leptin Resistance: Why, Where, and How”. Philadelphia, PA, June, 2001.
76. Research Seminar, RepliGen Corporation, Needham, MA, Oct, 2001.
77. Research Seminar, Southern Illinois University School of Medicine, Springfield, IL, Jan,
2002.
78. Mechanisms and Therapeutics of Neurological Disease: Impact of the Blood-Brain
Barrier, Portland, OR, May, 2002.
79. Barriers of the CNS: Blood-Brain-CSF Barriers, CNS Homeostasis and Drug Delivery to
the Brain, Gordon Research Conference, Session Chair, Tilton School, NH, June, 2002.
80. Symposiym: Transport At the Blood Brain Barrier: A Role in EnvironmentalF Disease?
NIEHS, Research Triangle Park, NC Sept, 2002.
81. Cayman V: Peptide Biology Discovery to Therapy, Session Discussion Leader,
Providenciale, Turks and Caicos, Oct, 2002.
82. Immunology 2003, American Association of Immunologists 90th Anniversary Annual
Meeting. May, 2003.
83. 10th Annual Meeting of the Psychoneuroimmunology Research Society, Amelia Island,
Florida, June, 2003.
84. 5th International Conference on Cerebrovascular Biology: 2003. Speaker and Panel
Discussant. Amarillo, TX, June, 2003.
85. Dietary Fat and Energy Balance: Myths and Facts. Speaker and Session Chair, Ascona,
Switzerland, July, 2003.
86. 6th International Symposium on VIP, PACAP and Related Peptides. Speaker and Session
Chair, Hakone, Japan, Sept, 2003.
87. Special Lecture, Department of Pharmacobio-dynamics, Faculty of Pharmaceutical
Sciences, Kanazawa University, Takara-machi, Kanazawa, Japan, Sept, 2003.
88. Seminar, Membrane Transport and Drug Targeting Laboratory and Advanced Science
and Technology of Bioactive Materials Laboratory, Department of Molecular
Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku
University, Sendai, Japan, Sept, 2003.
89. Research Seminar, Department of 1st Anatomy, Showa University School of Medicine,
Tokyo, Japan, Sept, 2003.
90. Research Seminar, BioMarin Pharmaceutical, Inc, Novato, CA, Oct, 2003.
91. Joint Drug Delivery Neurosciences Seminar series, University of Nebraska Medical
Center, Omaha, NB, Dec, 2003.
92. Research Seminar, Department of Chemistry, University of Missouri-Rolla, Rolla, MO,
Feb, 2004.
93. 2004 Conference of the Society for Neuroimmune Pharmacology, Plenary Speaker, Santa
Fe, NM, March, 2004.
94. Research Seminar, Department of Biology, Seton Hall University, South Orange, NJ,
April, 2004.
95. Research Seminar, CNS Division-Alzheimer’s Disease Group, F. Hoffman-La Roche
Ltd, Basel, Switzerland, June, 2004.
96. International Behavioral Neuroscience Society Annual Meeting, Speaker and Co-Chair,
Key West, Florida, June, 2004.
97. Gordon Research Conference: Barriers of the CNS, Session Chair and Speaker, Tilton
School, NH, June-July, 2004.
98. 16th International Congress of the International Federation of Associations of Anatomists,
Co-Chair and Speaker, Kyoto, Japan, August, 2004.
99. 1st Annual Meeting of the Showa University International Symposium for Life Sciences:
New Frontiers in Neuroscience Research, Tokyo, Japan, August, 2004.
100. Milton D. Overholser Memorial Lecture, 47th Annual Physicians Alumini Weekend,
Columbia, MO, Oct, 2004.
101. North American Association for the Study of Obesity 2004 Annual Meeting, Las Vegas,
Nevada, Nov. 2004.
102. 57th Annual Scientific Meeting of the Geriatric Society of America, Special Symposium:
GRECC Tribute to Marsh Goodwin-Beck: Scientific Breakthroughs, Washington, DC,
November 2004.
103. 25th European Winter Conference on Brain Research, Arc 1800, France, March 2005.
104. CNS Delivery Minisymposium, Centocor, Inc., Malvern, PA, April 2005.
105. New York Academy of Sciences Symposium “The Blood Brain Barrier: Getting Drugs
into the Brain, New York, New York, April, 2005.
106. 3rd International Academy on Nutrition and Aging, Session Chair and Speaker, St. Louis,
MO, May, 2005.
107. 12th Annual Meeting of the Psychoneuroimmunology Research Society, Speaker and Co-
Chair, Denver, CO, June, 2005.
108. 19th Annual Meeting of the Associated Professional Sleep Societies, LLC, Denver, CO,
June, 2005.
109. VIth Conference on Cerebral Vascular Biology and 8th International Symposium on
Signal Transduction in the Blood-Brain Barriers, Session Co-Chair, Munster, Germany,
June, 2005.
110. 13th Annual Meeting of the Society for the Study of Ingestive Behavior, Pittsburg, PN,
July, 2005.
111. Nasal Drug Delivery: BBB, Regulation, Formulation & Drug Delivery, Sponsored by
Pharmaceutical Education Associates, Washington, DC, July, 2005.
112. Peripheral-Central Interactions in the Control of Food Intake and Energy Balance
Workshop. Swiss Federal Institute of Technology, Ascona, Switzerland, August-
September, 2005.
113. 7th International Symposium of the CIHR Research Chair in Obesity: The Neurobiology
of Obesity, University of Laval, Quebec, Canada, November, 2005.
114. 3rd Annual Meeting of The Global College of Neuroprotection and Neuroregeneration,
Speaker and Co-chair, Uppsala, Sweden, March, 2006.
115. Research Presentation, Department of Geriatrics, Peking University First Hospital,
Beijing, China, March, 2006.
116. Research Presentation, Department of Neurology, Beijing Chaoyang Hospital, Beijing,
China, March, 2006.
117. 29th Annual Meeting of the Japan Society for Neurotraumatology, Special Lecture,
Showa University, Tokyo, Japan, March, 2006.
118. Research Seminar, Brain Research Centre, University of British Columbia, Vancouver,
BC, Canada, April, 2006.
119. Neuroendocrinological Regulation of Food Intake Symposium, A.I. Virtanen Institute for
Molecular Sciences and Department of Clinical Nutrition, Session Chair and Speaker,
Kuopio Finland, May 2006.
120. American Diabetes Association’s 66th Scientific Session, Washington, DC, June, 2006.
121. Research Seminar, Department of Biochemistry, TC Marmara University, Istanbul,
Turkey, June, 2006.
122. Research Seminar, Experimental Medical Research Institute and Brain Research
Association Joint Lecture, Istanbul University, Istanbul, Turkey, June, 2006.
123. Masterfoods Keynote Lecture, Society for the Study of Ingestive Behavior Annual
Meeting, Naples, Florida, July 2006.
124. Gordon Research Conference, Drug Carriers in Medicine and Biology, Big Sky, MT,
August, 2006.
125. Research Seminar, Biogen-Idec, Boston, MA, September, 2006.
126. Research Seminar, Department of Neurology and Neurological Sciences, Stanford
University, Stanford, CA, Oct, 2006.
127. Research Seminar, Pharmacology Division, College of Pharmacy, University of
Missouri-Kansas City, Kansas City, MO, Oct, 2006
128. Research Seminar, Amylin Pharmaceuticals, Inc., San Diego, CA, Oct, 2006.
129. Research Seminar, Pennington Biomedical Research Center, Baton Rouge, LA, Oct,
2006.
130. Seminars in Neuroscience Series, Dept of Neurobiology and Anatomy, West
Virginia University, Morgantown, WV, Nov 2006.
131. Research Seminar for Pharmacology and Graduate College, Rush University Medical
Center, Chicago, IL, Nov, 2006.
132. Seminar and Scientific Advisory Panel, Medtronic, Minneapolis, MN, Nov. 2006.
133. 40th Annual Winter Conference on Brain Research, Snowmass, Co, Jan-Feb, 2007.
134. Drug Discovery, Development & Delivery for Neurodegeneration Diseases: A Course
for Academnic & Industry Scientists, Alzheimer’s Drug Discovery Foundation and
Institute for the Study of Aging, New York, NY, Feb 2007.
135. Center for Membrane Sciences symposium, University of Kentucky, Lexington, KY, Feb 2007.
136. Fourth Annual Meeting of the Global College of Neuroprotection and
Neurodegeneration, Garmisch-Partenkirchen, Germany, March, 2007.
137. Thirteenth Annual Blood-brain Barrier Consortium Meeting in collaboration with the
International Brain Barriers Society. Speaker and Co-chair. Skamania Lodge, Stevenson,
WA, March 2007.
138. Clinical Seminar Lecture, Mercer University School of Medicine, Macon, GA, May
2007.
139. Basic Science Seminar, Mercer University School of Medicine, Macon, GA, May 2007.
140. Global CNS Drugs Summit, Philadelphia, PA, May 2007.
141. 7th Cerebral Vascular Biology International Conference. Session co-chair. Ottawa,
Canada, June, 2007.
142. 4th International Peptide Symposium & 2nd Asia-Pacific International Peptide
Symposium. Cairns, Australia, Oct, 2007.
143. 1st International Conference on Drug Design & Discovery. Speaker and co-chair (2
sessions). Dubai, United Arab Emirates, Feb, 2008.
144. Society on Neuroimmune Pharmacology 14th Annual Conference. Speaker and co-chair.
Charleston, SC, March, 2008.
145. Society for Endocrinology BES 2008. Harrogate, UK, April, 2008.
146. The 7th International Duodecim Symposium: Obesity and the Gut-Brain-Fat Axis.
Vanajanlinna, Finland, June, 2008.
147. Gordon Research Conference: Barriers of the CNS-2008, Session Chair and Speaker,
Tilton School, NH, June-July, 2008.
148. Research Talk, University of Washington, Seattle, WA, Nov, 2008.
149. Research Talk, GRECC-VA, Seattle, WA, Nov, 2008.
150. Research Talk, Center for Human Nutrition, Washington University, St. Louis, MO, Dec 2008.
151. Neurology/Psychiatry Grand Rounds, Saint Louis University School of Medicine, St.
Louis, MO, Dec, 2008.
152. Research Talk, Departments of Neurology, Molecular and Comparative Pathology, Johns
Hopkins University, Baltimore, MD, Jan, 2009.
153. 2009 Drug Discovery for Neurodegeneration Conference. Washington, DC, Feb 2009.
154. Second Joint Congress of the Global College of Neuroprotection and Neuroregeneration (6th
Congress) and the Society for the Study of Neuroprotection and Neuroplasticity (5th
Congress). Speaker and Session Co-Chair. Vienna, Austria, March 2009.
155. NIDDK Brain & Obesity Intramural Lecture Series. National Institutes of Health.
Bethesda, MD, May 2009.
156. Research Talk, Pfizer, Global Research and Development. St. Louis, MO , May 2009.
157. Cerebrovascular Biology 2009. Speaker, Session Co-chair, International Organizing
Committee, and International Scientific Program Committee. Sendai, Japan, June-July,
2009.
158. Invited Speaker to the Committee to Review Adverse Effects of Vaccines, Institute of
Medicine of the National Academies. Washington, DC, August, 2009.
159. Research Talk, Pacific Northwest Diabetes Research Institute, Seattle, WA, Sept, 2009.
160. Keynote Address, COBRE Nebraska Center for Nanomedicine Retreat and Review,
Nebraska City, NE, Sept, 2009.
161. 9th International Symposium on VIP, PACAP and Related Peptides. Scientific Advisory
Committee, Session Co-chair, and Akira Arimura Memorial Symposium Lecturer.
Kagoshima, Japan, Oct, 2009.
162. Research Seminar, Department of Pharmacology 1, Nagasaki University School of
Medicine, Nagasaki, Japan, Oct, 2009.
163. Research Seminar, Department of Pharmaceutical Care and Health Sciences, Faculty of
Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan, Oct, 2009.
164. Research Seminar, Department of 1st Anatomy, Showa University School of Medicine,
Tokyo, Japan, Oct, 2009.
165. Scientific Lecture, 52nd Annual Physicians Alumini Weekend, Columbia, MO, Oct, 2009.
166. Presentation to NIH-Rapid Access to Interventional Development (NIH-RAID) Program.
Bethesda, MD, Jan 2010.
167. 11th Annual Mary Murphy, BVM Endowed Lecture in Biology, Clarke College,
Dubuque, IA, March 2010.
168. The Intestinal Wall: THE Regulatory Interface in Energy Metabolism. Swiss Federal
Institute of Technology, Ascona, Switzerland, June, 2010.
169. The Third Cellular Delivery of Therapeutic Macromolecules International Symposium.
Cardiff University, Cardiff, Wales, June, 2010.
170. Scientific Symposium, Bristol-Myers Squibb Company, Princeton, NJ, Oct, 2010.
171. Cayman IX: Peptides in Health and Disease, Christ Church, Barbados, Oct 2010.
172. Scientific Lecture, Department of Physiology and Pharmacology, Oregon Health and
Science Center, Portland, Oregon, January, 2011.
173. NIH Workshop, Toward a Clinical Definition of Leptin Resistance, NIH Campus,
Bethesda, MD, February, 2011.
174. 42nd Annual Meeting of the American Society for Neurochemistry, St. Louis, MO,
March, 2011.
175. Research Lecture, Shire Human Genetic Therapies, Boston, MA, May, 2011.
176. Workshop Drug Delivery and Disposition of Biotherapeutics Across the Blood-brain
Barrier, American Association of Pharmaceutical Scientists, San Francisco, CA, May,
2011.
177. The Role of the Blood-brain Barrier in Disease States Symposium, XXVth International
Symposium on Cerebral Blood Flow, Metabolism, and Function & Xth International
Conference on Quantification of Brain Function with PET, Barcelona, Spain, May 2011.
178. 9th International Conference on Cerebral Vascular Biology, Leiden, The Netherlands,
June 201l.
179. Alzheimer’s Association International Conference 2011, Paris, France. Session
organizer, co-chair, and speaker. July 2011.
180. CNS Drug Delivery: From Proof of Concept to Clinical Readiness (Educational
Workshop), Controlled Release Society 38th Annual Meeting & Exposition. Workshop
co-organizer, session chair, and speaker. July 2011.
181. Research Seminar, Pennington Biomedical Research Center, Baton Rouge, LA, Oct, 2011.
182. Grand Rounds, Department of Psychiatry, University of Washington, Seattle, WA, Nov,
2011; April, 2013.
183. Research Seminar, Program in Neuroscience, Florida State University, Tallahassee, FL,
Nov, 2011.
184. NIH Intramural Brain & Obesity Lectures, Bethesda, MD, March, 2012.
185. American Society for Nutrition 2012 Scientific Sessions and Annual Meeting at
Experimental Biology, San Diego, CA, April, 2012.
186. Presidential Address, American Society for Neural Therapy and Repair, Clearwater, FL,
April, 2012.
187. Boston University Symposium on Therapeutics Innovation: The Next Generation of
Discovery. Boston, MA, April 2012.
188. Keynote Address, 19th Annual Psychoneuroimmunology Research Society Scientific
Meeting. San Diego, CA, June 2012.
189. Long-term Effects of GH/IGF-1 Reduction, Clinical and Translational Symposium
Session, The Endocrine Society’s 94th Annual Meeting and Expo, Houston, TX, June
2012.
190. Research and Teaching Seminar, California Northstate University College of Medicine,
Elk Grove, CA, July 2012.
191. Fifteenth International Symposium on Signal Transduction in the Blood-brain Barriers.
Speaker and Session Co-chair. Potsdam, Germany, Sept 2012.
192. 3rd Meeting of the Japan Branch of the International Neuropeptide Society, Kitakyushu,
Japan. Speaker and Session Co-chair. Sept 2012.
193. Research Lecture, Division of Endocrinology, Department of Internal Medicine.
University of California – Davis, Davis, CA, Nov 2012.
194. Special Seminar, Join Hosts of Department of Internal Medicine, Department of
Physiology & Membrane Biology, and UC Davis Brain Injury and Neuropathology
Group. Davis, CA, Jan 2013.
195. Research Seminar, Pharmacology Department, Johns Hopkins School of Medicine,
Baltimore, MD, Feb 2013.
196. Brains for Brain Workshop. Frankfurt, Germany. March 2013.
197. CIHR Training Program in Biological Therapeutics Symposium: Enabling Novel
Biotherapeutic Modalities: Understanding Physiologic Barriers to CNS and Systemic
Delivery of Macromolecules. Faculty of Pharmacy, University of Toronto, May 2013.
198. XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function.
Co-Chair of Brain Course “Tools for Studying the Blood Bran Barrier and Neurovascular
Unit; Speaker and Co-Chair in Symposium “Diseases of the Blood-brain Barrier”.
Shanghai, China, May 2013.
199. MedSci 2013. Joint AWCBR/MedSci Plenary Lecture. Queenstown, New Zealand,
August 2013.
200. MedSci 2013 Symposium: Mechanisms of Signalling, Across the Blood Brain Barrier.
Queenstown, New Zealand, August 2013.
201. Lecture/Round Table Discussion, Centre for Neuroendocrinology. University of Otago,
Dunedin, New Zealand, August 2013.
202. Faculty Research Seminar, California Northstate University College of Medicine. Elk
Grove, CA, Sept, 2013.
203. Department of Pharmacology Seminar, Rush Medical College, Chicago, IL, October,
2013.
204. Grand Rounds, Department of Medicine, University of Washington School of Medicine,
Seattle, WA, Feb, 2014.
205. Twentieth Annual Blood-brain Barrier Consortium Meeting, Sunriver, OR, March, 2014.
206. 5th International Pharmaceutical Federation (FIP) Pharmaceutical Sciences World
Congress, Key Note Speaker; Meet the Experts Symposium, Melbourne, Australia, April,
2014.
207. Department of Pathology and Laboratory Medicine Seminar, Temple University,
Philadelphia, PA, May, 2014.
208. 2014 Norman Cousins Award Memorial Lecture, Psychoneuroimmune Research Society,
Philadelphia, PA, May, 2014.
209. The Jim Flood Memorial Alzheimer’s Disease Lecture, Saint Louis University Summer
Geriatric Institute, St. Louis, MO, June, 2014.
210. 20th International Symposium on Regulatory Peptides, Scientific Program Committee,
Session Chair, Speaker; Kyoto, Japan, Sept, 2014.
211. All Roads Take to the Brain: Neural Control of Energy Homeostasis in Health and
Disease Workshop. Swiss Federal Institute of Technology, Ascona, Switzerland, Sept,
2014.
212. Department of Pharmacology Seminar, University of Texas Health Science Center at San
Antonio, San Antonio, TX, Oct, 2014.
213. Department of Anesthesiology & Perioperative Medicine, Oregon Health Sciences
University, Portland, OR, Oct, 2014.
214. Seminar, Novartis, Cambridge, MA Nov 2014.
215. Department of Pharmaceutics, University of Washington, April, 2015.
216. Department of Neurology, University of Pittsburg, Pittsburg, PA, May 2015.
217. Helmholtz Diabetes Center Summer Retreat 2015, Key Note Speaker, Grasgehrenhutte,
Obermaiselstein/Allgau, July 2015.
218. 12th International Symposium on VIP, PACAP and Related Peptides. Plenary Lecturer
and Session Chair, Cappadocia, Turkey, Sept 2015.
219. Blood-Brain Barrier Conference, Institute for Research in Biomedicine, Barcelona
BioMed Conferences. Speaker, Session Chair and Summary Speaker, Barcelona, Spain,
Nov 2015.
220. Biomedicine Course, PhD Program in Biomedical Sciences, Universidad de los Andes,
Santiago, Chile, Jan 2016.
221. Trans-Agency Blood Brain Interface Workshop 2016, NIH, Keynote Speaker, Bethesda,
MD, June 2016.

BIBLIOGRAPHY
NONABSTRACT MANUSCRIPTS

1. Averett, J.E., W.A. Banks, and D.E. Boehme. Negative allelopathic effects of rutin and
quercetin on fourteen soil and enteric microbes. Biochem. Syst. Ecol. 6: 1-3, 1978.
2. Rayford, P.L., S. Guzman, M. Miyata, W.A. Banks, and J.C. Thompson. Evidence for
vagal inhibition of gastrin release. Surg. Forum 30: 380-382, 1979.
3. Guzman, S., J.-A. Chayvialle, W.A. Banks, P.L. Rayford, and J.C. Thompson. Effect of
vagal stimulation on pancreatic secretion and on blood levels of gastrin, cholecystokinin,
secretin, vasoactive intestinal peptide, and somatostatin. Surgery 86:329-336, 1979.
4. Banks, W.A. Evidence for a cholecystokinin gut-brain axis with modulation by
bombesin. Peptides 1: 347-351, 1980.
5. Kastin, A.J., W.A. Banks, N. Marks, and R.D. Olson. Dissociative effects of CNS
peptides with some unusual applications of RIA. In: Physiological Peptides and New
Trends in Radioimmunology, Ch. A. Bizollon (ed.), Elsevier, Amsterdam, pp 89-99,
1981.
6. Kastin, A.J., P.F. Castellanos, W.A. Banks, and D.H. Coy. Radioimmunoassay of DSIPlike
material in human blood: Possible protein binding. Pharmacol. Biochem. Behav. 15:
969-974, 1981.
7. Banks, W.A., A.J. Kastin, and D.H. Coy. Delta sleep-inducing peptide crosses the bloodbrain-
barrier in dogs: Some correlations with protein binding. Pharmacol. Biochem.
Behav. 17: 1009-1014, 1982.
8. Kastin, A.J., W.A. Banks, P.F. Castellanos, C. Nissen, and D.H. Coy. Differential
penetration of DSIP peptides into rat brain. Pharmacol. Biochem. Behav. 17: 1187-1191,
1982.
9. Kastin, A.J., W.A. Banks, J.E. Zadina, and M. Graf. Minireview: Brain peptides: The
dangers of constricted nomenclatures. Life Sciences 32: 295-301, 1983.
10. Banks, W.A., A.J. Kastin, and D.H. Coy. Delta sleep-inducing peptide (DSIP) like
material is absorbed by the gastrointestinal tract of the neonatal rat. Life Sciences 33:
1587-1597, 1983.
11. Banks, W.A., and A.J. Kastin. Aluminium increases permeability of the blood-brain
barrier to labelled DSIP and beta-endorphin: Possible implications for senile and dialysis
dementia. The Lancet ii: 1227-1229, 1983.
30
12. Banks, W.A. and A.J. Kastin. CSF-plasma relationships for DSIP and some other
neuropeptides. Pharmacol. Biochem. Behav. 19: 1037-1040, 1983.
13. Kastin, A.J., J.E. Zadina, W.A. Banks, and M.V. Graf. Misleading concepts in the field
of brain peptides. Peptides 5(S1): 249-253, 1984.
14. Banks, W.A., A.J. Kastin, and D.H. Coy. Evidence that [125I]N-Tyr-delta sleep-inducing
peptide crosses the blood-brain barrier by a non-competitive mechanism. Brain Res. 301:
201-207, 1984.
15. Banks, W.A., A.J. Kastin, E.G. Biglieri, and A.E. Ruiz. Primary adrenal hyperplasia: A
new subset of primary hyperaldosteronism. J. Clin. Endocrinol. Metab. 58: 783-785,
1984.
16. Banks, W.A. and A.J. Kastin. A brain-to-blood carrier-mediated transport system for
small, N-tyrosinated peptides. Pharmacol. Biochem. Behav. 21: 943-946, 1984.
17. Banks, W.A. and A.J. Kastin. Aluminum alters the permeability of the blood-brain
barrier to some non-peptides. Neuropharmacology 24: 407-412, 1985.
18. Banks, W.A. and A.J. Kastin. The aluminum-induced increase in blood-brain barrier
permeability to delta-sleep-inducing peptide occurs throughout the brain and is
independent of phosphorus and acetylcholinesterase levels. Psychopharmacology 86: 84-
89, 1985.
19. Banks, W.A. and A.J. Kastin. Peptides and the blood-brain barrier: Lipophilicity as a
predictor of permeability. Brain Res. Bull. 15: 287-292, 1985.
20. Banks, W.A., A.J. Kastin, and E.A. Michals. Transport of thyroxine across the bloodbrain
barrier is directed primarily from brain to blood in the mouse. Life Sciences 37:
2407-2414, 1985.
21. Banks, W.A. and A.J. Kastin. Aging and the blood-brain barrier: Changes in the carriermediated
transport of peptides in rats. Neurosci. Lett. 61: 171-175, 1985.
22. Banks, W.A., A.J. Kastin, and J.K. Selznick. Modulation of immunoactive levels of
DSIP and blood-brain barrier permeability by lighting and diurnal rhythm. J. Neurosci.
Res. 14: 347-355, 1985.
23. Banks, W.A. and A.J. Kastin. Permeability of the blood-brain barrier to neuropeptides:
The case for penetration. Psychoneuroendocrinology 10: 385-399, 1985.
24. Banks, W.A. and A.J. Kastin. Aging, peptides, and the blood-brain barrier: Implications
31
and speculations. In: Treatment Development Strategies for Alzheimer’s Disease, T.
Crook, R. Bartus, S. Ferris, and S. Gershon (eds.), Mark Powley Associates, Madison,
CT, pp 245-265, 1986.
25. Zadina, J.E., W.A. Banks, and A.J. Kastin. Central nervous system effects of peptides,
1980-1985: A cross-listing of peptides and their central actions from the first six years of
the journal Peptides . Peptides 7: 497-537, 1986.
26. Banks, W.A., A.J. Kastin, D.H. Coy, and E. Angulo. Entry of DSIP peptides into dog
CSF: Role of physicochemical and pharmacokinetic parameters. Brain Res. Bull. 17:
155-158, 1986.
27. Banks, W.A., A.J. Kastin, A.J. Fischman, D.H. Coy, and S.L. Strauss. Carrier-mediated
transport of enkephalins and N-Tyr-MIF-1 across blood-brain barrier. Am. J. Physiol.
251: E477-E482, 1986.
28. Pretorius, H.T., A.J. Kastin, and W.A. Banks. Binding of Tyr-MIF-1 to isolated brain
capillaries. Brain Res. Bull. 17: 829-831, 1986.
29. Banks, W.A. and A.J. Kastin. Modulation of the carrier-mediated transport of the Tyr-
MIF-1 across the blood-brain barrier by essential amino acids. J. Pharmacol. Exp. Ther.
239: 668-672, 1986.
30. Kastin, A.J., R.D. Olson, J.E. Zadina, and W.A. Banks. Relationship of clinical to basic
research with peptides as illustrated by MSH. In: Neural and Endocrine Peptides and
Receptors, T.W. Moody (ed.), Plenum Press, pp 645-652, 1986.
31. Kastin, A.J., R.H. Ehrensing, W.A. Banks, and J.E. Zadina. Possible therapeutic
implications of the effects of some peptides on the brain. In: Progress in Brain Research,
E.R. de Kloet, V.M. Wiegant, and D. de Wied (eds.), Elsevier Science Publishers B.V.,
Amsterdam, 72: 223-234, 1987.
32. Kastin, A.J. and W.A. Banks. Peptides and the blood-brain barrier. In: Encyclopedia of
Neuroscience, Vol. 1, G. Adelman (ed.), Birkhauser, Inc., Boston. pp 937-938, 1987.
33. Banks, W.A. and A.J. Kastin. Minireview: Saturable transport of peptides across the
blood-brain barrier. Life Sciences 41: 1319-1338, 1987.
34. Banks, W.A., A.J. Kastin, and E.A. Michals. Tyr-MIF-1 and met-enkephalin share a
saturable blood-brain barrier transport system. Peptides 8: 899-903, 1987.
35. Barrera, C.M., A.J. Kastin, and W.A. Banks. D-[Ala1]-Peptide T-amide is transported
from blood to brain by a saturable system. Brain Res. Bull. 19: 629-633, 1987.
32
36. Banks, W.A., A.J. Kastin, A. Horvath, and E.A. Michals. Carrier-mediated transport of
vasopressin across the blood-brain barrier of the mouse. J. Neurosci. Res. 18: 326-332,
1987.
37. Banks, W.A., A.J. Kastin, and B.J. Nager. Analgesia and the blood-brain barrier transport
system for Tyr-MIF-1/enkephalins: Evidence for a dissociation. Neuropharmacology 27:
175-179, 1988.
38. Banks, W.A., A.J. Kastin, and M.B. Fasold. Differential effect of aluminum on the bloodbrain
barrier transport of peptides, technetium, and albumin. J. Pharmacol. Exp. Ther.
244: 579-585, 1988.
39. Banks, W.A. and A.J. Kastin. Commentary: Peptides and the senescent blood-brain
barrier. Neurobiol. Aging 9: 48-49, 1988.
40. Banks, W.A. and A.J. Kastin. Twenty-one hormones fail to inhibit the brain to blood
transport system for Tyr-MIF-1 and the enkephalins in mice. J. Pharm. Pharmacol. 40:
289-291, 1988.
41. Kastin, A.J., J.E. Zadina, G.A. Olson, and W.A. Banks. Considerations regarding some
peptides involved in biorhythms, reproduction, stress, and pineal function. In:
Biorhythms and Stress in the Physiopathology of Reproduction, P. Pancheri and L.
Zichella (eds.), Hemisphere Publishing Corporation, New York, pp 11-19, 1988.
42. Banks, W.A. and A.J. Kastin. Review: Interactions between the blood-brain barrier and
endogenous peptides: Emerging clinical implications. Am. J. Med. Sci. 295: 459-465,
1988.
43. Banks, W.A., A.J. Kastin, C.M. Barrera, and D.A. Durham. Movement of peptides
between the blood and the central nervous system: A brief perspective. In: European
Conference on Biotechnology: Scientific, Technical, and Industrial Challenges,
Agricenter, Verona, Italy, pp 135-140, 1988.
44. Banks, W.A. and A.J. Kastin. Peptides and the blood brain barrier: Penetration and
modulating influences. In: Peptide and Amino Acid Transport Mechanisms in the Central
Nervous System, Lj. Rakic, D.J. Begley, H. Davson, and B.V. Zlokovic (eds.),
Stockton/Macmillan Press Ltd., London, pp 21-32, 1988.
45. Banks, W.A., T.L. Trentman, A.J. Kastin, and Z.H. Galina. The general anesthesia
induced by various drugs differentially affects analgesia and its variability. Pharmacol.
Biochem. Behav. 31: 397-403, 1988.
46. Banks, W.A., A.J. Kastin, M.B. Fasold, C.M. Barrera, and G. Augereau. Studies of the
slow bidirectional transport of iron and transferrin across the blood-brain barrier. Brain
33
Res. Bull. 21: 881-885, 1988.
47. Banks, W.A., A.J. Kastin, T.L. Trentman, H.S. Haynes, B.G. Johnson, and Z.H. Galina.
Mediation of serotonin-induced analgesia by the 5HT2 receptor in the pentobarbital
anesthetized mouse model. Brain Res. Bull. 21: 887-891, 1988.
48. Banks, W.A. and A.J. Kastin. Inhibition of the brain to blood transport system for
enkephalins and Tyr-MIF-1 in mice addicted or genetically predisposed to drinking
ethanol. Alcohol 6: 53-57, 1989.
49. Banks, W.A. and A.J. Kastin. Quantifying carrier-mediated transport of peptides from the
brain to the blood. In: Hormone Action, Part K, Neuroendocrine Peptides. P. Michael
Conn (ed.), Meth. Enzymol., 168: 652-660, 1989.
50. Banks, W.A. and A. J. Kastin. Effect of neurotransmitters on the system that transports
Tyr-MIF-1 and the enkephalins across the blood-brain barrier: A dominant role for
serotonin. Psychopharmacology 98: 380-385, 1989.
51. Banks, W.A. and A.J. Kastin. Aluminum-induced neurotoxicity: Alterations in membrane
function at the blood-brain barrier. Neurosci. Biobehav. Rev. 13: 47-53, 1989.
52. Banks, W.A., A.J. Kastin, and D.A. Durham. Bidirectional transport of interleukin-1
alpha across the blood-brain barrier. Brain Res. Bull. 23: 433-437, 1989.
53. Barrera, C.M., W.A. Banks, and A.J. Kastin. Passage of Tyr-MIF-1 from blood to brain.
Brain Res. Bull. 23: 439-442, 1989.
54. Banks, W.A. and J.A. Cooper. Hypoxia and hypercarbia of chronic lung disease: Minimal
effects on anterior pituitary function. South. Med. J. 83: 290-293, 1990.
55. Kastin, A.J., W.A. Banks, and J.E. Zadina. Hormones and messenger peptides in normal
brain function. In: Principles and Practice of Endocrinology and Metabolism, K.L.
Becker (ed.), J.B. Lippincott Co., Philadelphia, PA, pp 1474-1479 and pp 1609-1610,
1990.
56. Kastin, A.J., W.A. Banks, and J.E. Zadina. A decade of changing perceptions about
neuropeptides. In: A Decade of Neuropeptides: Past, Present, and Future, G.F. Koob,
C.A. Sandman, and F.L. Strand (eds.), Ann. NY Acad. Sci. 579: 1-7, 1990.
57. Banks, W.A. and A.J. Kastin. Editorial Review: Peptide transport systems for opiates
across the blood-brain barrier. Am. J. Physiol. 259: E1-E10, 1990.
58. Banks, W.A. and A.J. Kastin. Uptake of peptides containing Tyr-Pro by human and
mouse erythrocytes. Biochem. Pharmacol. 40: 607-614, 1990.
34
59. Banks, W.A., A.V. Schally, C.M. Barrera, M.B. Fasold, D.A. Durham, V.J. Csernus, K.
Groot, and A.J. Kastin. Permeability of the murine blood-brain barrier to some
octapeptide analogs of somatostatin. Proc. Natl. Acad. Sci. USA 87: 6762-6766, 1990.
60. Banks, W.A. and A.J. Kastin. Exchange of peptides between the circulation and the
nervous system: Role of the blood-brain barrier. In: Circulating Regulatory Factors and
Neuroendocrine Function, J.C. Porter and D. Jezova (eds.), Plenum Press, NY, Adv. Exp.
Med. Biol. 274: 59-69, 1990.
61. Banks, W.A., A.J. Kastin, E.A. Michals, and C.M. Barrera. Stereospecific transport of
Tyr-MIF-1 across the blood-brain barrier by peptide transport system-1. Brain Res. Bull.
25: 589-592, 1990.
62. Banks, W.A. and A.J. Kastin. Leucine modulates peptide transport system-1 across the
blood-brain barrier at a stereospecific site within the central nervous system. J. Pharm.
Pharmacol. 43: 252-254, 1991.
63. Durham, D.A., W.A. Banks, and A.J. Kastin. Carrier-mediated transport of labeled
oxytocin from brain to blood. Neuroendocrinology 53: 447-452, 1991.
64. Banks, W.A. and A. J. Kastin. Regulation of the passage of peptides across the bloodbrain
barrier. In: Pharmacokinetics and Pharmacodynamics, Volume 3, Peptides,
Peptoids, and Proteins, P.D. Garzone, W.A. Colburn, and M. Mokotoff (eds.), Harvey
Whitney Books, Cincinnati, OH, pp 147-153, 1991.
65. Banks, W.A. and A.J. Kastin. Blood to brain transport of interleukin links the immune
and central nervous systems. Life Scences. 48: PL117-PL121, 1991.
66. Barrera, C.M., A.J. Kastin, M.B. Fasold, and W.A. Banks. Bidirectional saturable
transport of LHRH across the blood-brain barrier. Am. J. Physiol. 261: E312-318, 1991.
67. Banks, W.A., A.J. Kastin, and C.M. Barrera. Delivering peptides to the central nervous
system: Dilemmas and strategies. Pharm. Res. 8: 1345-1350, 1991.
68. Kastin, A.J., M.A. Pearson, and W.A. Banks. EEG evidence that morphine and an
enkephalin analog cross the blood-brain barrier. Pharmacol. Biochem. Behav. 40: 771-
774, 1991.
69. Banks, W.A., A.J. Kastin, C.M. Barrera, and L.M. Maness. Lack of saturable transport
across the blood-brain barrier in either direction for beta-amyloid1-28 (Alzheimer’s disease
protein). Brain Res. Bull. 27: 819-823, 1991.
70. Barrera, C.M., A.E. Ruiz, and W.A. Banks. A giant prolactinoma and the effect of
35
chronic bromocriptine therapy on basal and TRH-stimulated serum prolactin levels.
Hormone Res. 35: 167-169, 1991.
71. Banks, W.A., L. Ortiz, S.R. Plotkin, and A.J. Kastin. Human interleukin (IL)-1 alpha,
murine IL-1 alpha, and murine IL-1 beta are transported from blood to brain in the mouse
by a shared saturable mechanism. J. Pharmacol. Exp. Ther. 259: 988-996, 1991.
72. Barrera, C.M., W.A. Banks, M.B. Fasold, and A.J. Kastin. Effects of various
reproductive hormones on the penetration of LHRH across the blood-brain barrier.
Pharmacol. Biochem. Behav. 41: 255-257, 1992.
73. Banks, W.A. and A.J. Kastin. The interleukins -1 alpha, -1 beta, and -2 do not disrupt the
murine blood-brain barrier. Int. J. Immunopharmac. 14: 629-636, 1992.
74. Banks, W.A. and A.J. Kastin. Human interleukin-1 alpha crosses the blood-testis barriers
of the mouse. J. Andrology 13: 254-59, 1992.
75. Banks, W.A. and A.J. Kastin. Bidirectional passage of peptides across the blood-brain
barrier. In: Progress in Brain Research, A. Ermisch, R. Landgraf, and H.-J. Rühle (eds.),
Elsevier Science Publishers B.V., Amsterdam, 91: 139-148, 1992.
76. Banks, W.A. and A.J. Kastin. Exchange of peptides between the central nervous system
and the blood. CHIMICAoggi(CHEMISTRYtoday) 10: 38-40, 1992.
77. Banks, W.A., A.J. Kastin, and J.B. Jaspan. Orally administered cyclo(His-Pro) reduces
ethanol-induced narcosis in mice. Pharmacol. Biochem. Behav. 43: 939-941, 1992.
78. Zlokovic, B.V, W.A. Banks, H. El Kadi, J Erchegyi, J.B. Mackic, J.G. McComb, and A.J.
Kastin. Transport, uptake, and metabolism of blood-borne vasopressin by the blood-brain
barrier. Brain Res. 590: 213-218, 1992.
79. Banks, W.A., A.J. Kastin, S. Radulovic, F.K. Conley, D.L. Johnson, and A.V. Schally.
Selective uptake of the somatostatin analog RC-160 across the blood-brain tumor barrier
of mice with KHT sarcomas. Anti-Cancer Drugs 3: 519-523, 1992.
80. Banks, W.A., K.L. Audus, and T.P. Davis. Permeability of the blood-brain barrier to
peptides: An approach to the development of therapeutically useful analogs. Peptides 13:
1289-1294, 1992.
81. Banks, W.A., A.J. Kastin, V. Akerstrom, and J.B. Jaspan. Radioactively iodinated
cyclo(His-Pro) crosses the blood-brain barrier and reverses ethanol-induced narcosis.
Am. J. Physiol. 264: E723-E729, 1993.
82. Kastin, A.J., L. Fabre, W.A. Banks, and J.E. Zadina. The uptake, content, regulation of
36
plasma concentrations, and binding of Tyr-MIF-1 by the adrenals. Neuroendocrinology
57: 541-549, 1993.
83. Banks, W.A., A.J. Kastin, G.A. Olson, and R.D. Olson. Permeability of the blood-brain
barrier and the blood-testis barrier to LH, FSH, and albumin in younger and older mice.
Neuroendocrinology Lett. 15: 177-182, 1993.
84. Banks, W.A., A.J. Kastin, and C.A. Ehrensing. The endogenous peptide Tyr-Pro-Trp-
Gly-NH2 (Tyr-W-MIF-1) is transported from the brain to the blood by peptide transport
system (PTS)-1. J. Neurosci. Res. 35: 690-695, 1993.
85. Banks, W.A. and A.J. Kastin. The potential for alcohol to affect the passage of peptide
and protein hormones across the blood-brain barrier: A hypothesis for a disturbance in
brain-body communication. S. Zakhari (ed.) NIAAA Research Monograph No. 23,
Chapter 21, pp 401-411, 1993.
86. Banks, W.A., A.J. Kastin, G. Komaki, and A. Arimura. Pituitary adenylate cyclase
activating polypeptide (PACAP) can cross the vascular component of the blood-testis
barrier. J. Andrology 14: 170-173, 1993.
87. Gutierrez, E.G., W.A. Banks, and A.J. Kastin. Murine tumor necrosis factor alpha is
transported from blood to brain in the mouse. J. Neuroimmunology 47: 169-176, 1993.
88. Banks, W.A. and A.J. Kastin. Measurement of transport of cytokines across the bloodbrain
barrier. In: Neurobiology of Cytokines, Part A. E.B. De Souza (Ed.), Meth.
Neurosci. 16: 67-77, 1993.
89. Harrison, L.M., J.E. Zadina, W.A. Banks, A.J. Kastin. Effects of neonatal treatment with
Tyr-MIF-1, morphiceptin, and morphine on development, tail-flick, and blood-brain
barrier transport. Dev. Brain Res. 75: 207-212, 1993.
90. Broadwell, R.D. and W.A. Banks. A cell biological perspective for the transcytosis of
peptides and proteins through the mammalian blood-brain fluid barriers. In: Cellular and
Molecular Biology of the Blood-Brain Barrier. W.M. Pardridge (Ed.) Raven Press, New
York, pp 165-199, 1993.
91. Banks, W.A., A.J. Kastin, E.G. Gutierrez. Interleukin-1 alpha in blood has direct access
to cortical brain cells. Neurosci. Lett. 163: 41-44, 1993.
92. Banks, W.A., A.J. Kastin, G. Komaki, and A. Arimura. Passage of pituitary adenylate
cyclase activating polypeptide1-27 and pituitary adenylate cyclase activating polypeptide1-
38 across the blood-brain barrier. J. Pharmac. Exp. Ther. 267: 690-696, 1993.
93. Banks, W.A. and A.J. Kastin. Peptide binding in blood and passage across the blood37
brain barrier. In: Proceedings of the International Symposium Blood Binding and Drug
Transfer. J.P. Tillement, H. Eckert, E. Albengres, J. Barre, P. Baumann, F. Belpaire, and
M. Lemaire (Eds.). Editions Fort et Clair, Paris, pp 223-241, 1993.
94. Banks, W.A. and A.J. Kastin. Physiological consequences of the passage of peptides
across the blood-brain barrier. Rev. Neurosci. 4: 365-372, 1993.
95. Maness, L.M., A.J. Kastin, J.T. Weber, W.A. Banks, B.S. Beckman, and J.E. Zadina. The
neurotrophins and their receptors: Structure, function, and neuropathology. Neurosci.
Biobehav. Rev. 18: 143-159, 1994.
96. Banks, W.A. and A.J. Kastin. Opposite direction of transport across the blood-brain
barrier for Tyr-MIF-1 and MIF-1: Comparison with morphine. Peptides 15: 23-29, 1994.
97. Kastin, A.J., K. Hahn, J. Erchegyi, J.E. Zadina, L. Hackler, M. Palmgren, and W.A.
Banks. Differential metabolism of Tyr-MIF-1 and MIF-1 in rat and human plasma.
Biochem. Pharmacol. 47: 699-709, 1994.
98. Waguespack, P.J., W.A. Banks, and A.J. Kastin. Interleukin-2 does not cross the bloodbrain
barrier by a saturable transport system. Brain Res. Bull. 34: 103-109, 1994.
99. Banks, W.A. and R.D. Broadwell. Blood to brain and brain to blood passage of native
horseradish peroxidase, wheatgerm agglutinin, and albumin: Pharmacokinetic and
morphological assessments. J. Neurochem. 62: 2404-2419, 1994.
100. Kastin, A.J., W.A. Banks, K. Hahn, and J.E. Zadina. Extreme stability of Tyr-MIF-1 in
CSF. Neurosci. Lett. 174: 26-28, 1994.
101. Banks, W.A. and A.J. Kastin. Effects of aluminum on blood-brain barrier structure and
function. Life Chemistry Reports 11: 141-149, 1994.
102. Banks, W.A., A.J. Kastin, H.M. Sam, V.T. Cao, B. King, L.M. Maness, and A.V.
Schally. Saturable efflux of the peptides RC-160 and Tyr-MIF-1 by different parts of the
blood-brain barrier. Brain Res. Bull. 35: 179-182, 1994.
103. Ahmed, B., A.J. Kastin, W.A. Banks, and J.E. Zadina. CNS effects of peptides: A crosslisting
of peptides and their central actions published in the journal Peptides, 1986-1993.
Peptides 15: 1105-1155, 1994.
104. Banks, W.A., A.J. Kastin, and C.A. Ehrensing. Blood-borne interleukin-1 alpha is
transported across the endothelial blood-spinal cord barrier of mice. J. Physiol. 479.2:
257-264, 1994.
105. Broadwell, R.D., B.J. Baker, W.A. Banks, P. Friden, M. Moran, C. Oliver, and J.C.
38
Villegas. Ferrotransferrin and antibody against the transferrin receptor as potential
vehicles for drug delivery across the mammalian blood-brain barrier into the central
nervous sytem. In: Providing Pharmacologic Access to the Brain. T.R. Flanagan, D.F.
Emerich, and S.R. Winn (Eds.), Meth. Neurosci. 21: 93-117, 1994.
106. Banks, W.A., A.J. Kastin, and E.G. Gutierrez. Penetration of interleukin-6 across the
blood-brain barrier. Neurosci. Lett. 179: 53-56, 1994.
107. Maness, L.M., W.A. Banks, M.B. Podlisny, D.J. Selkoe, and A.J. Kastin. Passage of
human amyloid ß-protein 1-40 across the murine blood-brain barrier. Life Sciences
55:1643-1650, 1994.
108. Harrison, L.M., A.J. Kastin, J.T. Weber, W.A. Banks, D.L. Hurley, and J.E. Zadina. The
opiate system in invertebrates. Peptides 15: 1309-1329, 1994.
109. Kastin, A.J., W.A. Banks, R.D. Olson, and J.E. Zadina. Novel concepts from novel
peptides. In: Models of Neuropeptide Action, F.L. Strand, B. Beckwith, B. Chronwall,
and C.A. Sandman (Eds.), Ann. NY Acad. Sci. 739:1-10, 1994.
110. Banks, W.A. The blood-brain barrier: Methods for the study of peptide transport
mechanisms (Introduction to Part II). In: Models of Neuropeptide Action, F.L. Strand, B.
Beckwith, B. Chronwall, and C.A. Sandman (Eds.), Ann. NY Acad. Sci. 739:87-88,
1994.
111. Jaspan, J.B., W.A. Banks, and A.J. Kastin. Study of passage of peptides across the
blood-brain barrier: Biological effects of cyclo(His-Pro) after intravenous and oral
administration. In: Models of Neuropeptide Action, F.L. Strand, B. Beckwith, B.
Chronwall, and C.A. Sandman (Eds.), Ann. NY Acad. Sci. 739:101-107, 1994.
112. Banks, W.A. and A.J. Kastin. Brain-to-blood transport of peptides and the alcohol
withdrawal syndrome. In: Models of Neuropeptide Action, F.L. Strand, B. Beckwith, B.
Chronwall, and C.A. Sandman (Eds.), Ann. NY Acad. Sci. 739:108-118, 1994.
113. Kastin, A.J., K. Hahn, W.A. Banks, and J.E. Zadina. Delayed degradation of Tyr-MIF-1
in neonatal rat plasma. Peptides 15:1561-1563, 1994.
114. Gutierrez, E.G., W.A. Banks, and A.J. Kastin. Blood-borne interleukin-1 receptor
antagonist crosses the blood-brain barrier. J. Neuroimmunol. 55: 153-160, 1994.
115. Kastin, A.J., L. Fabre, W.A. Banks, L. Hackler, and J.E. Zadina. Increase in plasma Tyr-
MIF-1-like immunoreactivity after hypophysectomy is robust and reversible by
corticosterone. Neuropeptides 28: 65-71, 1995.
116. Banks, W.A. and A.J. Kastin. Blood-brain barrier permeability: Pharmacological
39
implications with special emphasis on peptides. In: Pharmacokinetics, 2nd Edition. P.G.
Welling and F. Tse (Eds.). Marcel-Dekker, New York, pp 119-138, 1995.
117. Bollinger, J.E., W.A. Banks, D.M. Roundhill. Review: Lipophilic hexadentate gallium,
indium and iron complexes of new phenolate-derivatized cyclohexanetriamine ligands as
potential in vivo metal transfer reagents. In: Current Trends in Coordination Chemistry,
G. Ondrejovic and A. Sirota (Eds). Slovak Technical University Press, Bratislava, pp
361-366, 1995.
118. Banks, W.A., A.J. Kastin, and J.B. Jaspan. Regional variation in transport of pancreatic
polypeptide across the blood-brain barrier of mice. Pharmacol. Biochem. Behav. 51: 139-
147, 1995.
119. Kastin, A.J., K. Hahn, J.E. Zadina, W.A. Banks, and L. Hackler. Melanocyte-stimulating
hormone release-inhibiting factor-1 (MIF-1) can be formed from Tyr-MIF-1 in brain
mitochondria but not in brain homogenate. J. Neurochem. 64: 1855-1859, 1995.
120. Bollinger, J.E., J.T. Mague, W.A. Banks, A.J. Kastin, and D.M. Roundhill. Lipophilic
hexadentate aluminum complexes of new phenolate-derivatized cyclohexanetriamine
ligands and their effect on the peptide transport system (PTS-1). Inorganic Chemistry 34:
2143-2152, 1995.
121. Kastin, A.J., W.A. Banks, B. Ahmed, and J.E. Zadina. Influence of hormones and
messenger peptides on normal brain function. In: Principles and Practice of
Endocrinology and Metabolism, Second Edition , K.L. Becker (Ed.), J.B. Lippincott Co.,
Philadelphia, PA, pp 1682-1691, 1995.
122. Banks, W.A. and A.J. Kastin. Permeability of the blood-brain barrier to melanocortins.
Peptides 16: 1157-1161, 1995.
123. Bollinger, J.E., J.T. Mague, C.J. O’Connor, W.A. Banks, and D.M. Roundhill. Lipophilic
hexadentate gallium, indium and iron complexes of new phenolate-derivatized
cyclohexanetriamines as potential in vivo metal-transfer reagents. J. Chem. Soc., Dalton
Trans. 1: 1677-1688, 1995.
124. Banks, W.A., D.J. Wustrow, W.L. Cody, M.D. Davis, A.J. Kastin. Permeability of the
blood-brain barrier to the neurotensin8-13 analog NT1. Brain Research 695:59-63, 1995.
125. Maness, L.M., W.A. Banks, J.E. Zadina, and A.J. Kastin. Selective transport of bloodborne
interleukin-1 alpha into the posterior division of the septum of the mouse brain.
Brain Research 700:83-88, 1995.
126. Banks, W.A., A.J. Kastin, L.M. Maness, W. Huang, and J.B. Jaspan. Permeability of the
blood-brain barrier to amylin. Life Sciences 57: 1993-2001, 1995.
40
127. Banks, W.A., S.R. Plotkin, A.J. Kastin. Permeability of the blood-brain barrier to soluble
cytokine receptors. NeuroImmunoModulation 2: 161-165, 1995.
128. Banks, W.A., A.J. Kastin, and P. Zatta. The blood-brain barrier in aluminium toxicity
and Alzheimer’s disease. In: Non-Neuronal Cells in Alzheimer’s Disease P. Zatta and
M. Nicolini (eds.). World Scientific, Singapore, pp 1-12, 1995.
129. Banks, W.A., A.J. Kastin, and R.D. Broadwell. Passage of cytokines across the bloodbrain
barrier. NeuroImmunoModulaton 2: 241-248, 1995.
130. Banks, W.A. and A.J. Kastin. Peptide transport system-1. In: New Concepts of a Blood-
Brain Barrier. J. Greenwood, D. Begley, and M.B. Segal (Eds.), Plenum Press, NY, pp
111-117, 1995.
131. Kastin, A.J., J.E. Zadina, R.D. Olson, W.A. Banks. The history of neuropeptide
research: Version 5.a. In: Neuropeptides: Basic and Clinical Advances, J.N. Crawley
and S. McLean (eds.), Ann. NY Acad. Sci. 780:1-18, 1996.
132. Banks, W.A. and A.J. Kastin. Reversible association of the cytokines MIP1-alpha and
MIP-1ß with the endothelia of the blood-brain barrier. Neurosci. Letts. 205:202-206,
1996.
133. Maness, L.M., W.A. Banks, J.E. Zadina, and A.J. Kastin. Periventricular penetration and
disappearance of icv Tyr-MIF-1, DAMGO, tyrosine, and albumin. Peptides 17:247-250,
1996.
134. Banks, W.A., A.J. Kastin, W. Huang, J.B. Jaspan, and L.M. Maness. Leptin enters the
brain by a saturable system independent of insulin. Peptides 17: 305-311,1996.
135. Martins, J.M., A.J. Kastin, and W.A. Banks. Unidirectional specific and modulated brain
to blood transport of corticotropin-releasing hormone. Neuroendocrinology 63: 338-
348,1996.
136. Bollinger, J.E., W.A. Banks, A.J. Kastin, D.M. Roundhill. Iron-59 complexes of
lipophilic hexadentate phenolate-derivatized cyclohexanetriamine ligands. (Harry Gray
Lecture). Inorganica Chimica Acta. 242: 201-204,1996.
137. Plotkin, S.R., W.A. Banks, and A.J. Kastin. Comparison of saturable transport and
extracellular pathways in the passage of interleukin-1 alpha across the blood-brain
barrier. J. Neuroimmunol. 67:41-47,1996.
138. Banks, W.A., S.A. Corrigan, J.A. West, P. P. Wilhoit, and P. Ryder. Psychological
profiles as predictors of success in a cardiovascular risk factors life-style intervention
41
program. South. Med. J. 89:971-976, 1996.
139. Cashion, M.F., W.A. Banks, A.J. Kastin. Sequestration of centrally administered insulin
by the brain: Effects of starvation, aluminum, and TNF alpha. Hormones and
Behavior 30: 280-286, 1996.
140. Banks, W.A. and A.J. Kastin. Minireview: Passage of peptides across the blood-brain
barrier: Pathophysiological perspectives. Life Sciences 59:1923-1943, 1996.
141. Uchida, D., A. Arimura, A. Somogyvári-Vigh, S. Shioda, and W.A. Banks. Prevention
of ischemia-induced death of hippocampal neurons by pituitary adenylate cyclase
activating polypeptide. Brain Research 736: 280-286, 1996.
142. Bollinger, J.E., W.A. Banks, A.J. Kastin, M.J. Welch, and D.M. Roundhill.
Biodistribution of the lipophilic complexes 59Fe(RsalH2)3tach (R=H, NO2, and OMe)
and 68Ga(NO2salH2)3tach. Nucl. Med. & Biol. 23:645-652, 1996.
143. Pan, W., W.A. Banks, M.K. Kennedy, E.G. Gutierrez, and A.J. Kastin. Differential
permeability of the BBB in acute EAE: Enhanced transport of TNF alpha. Am. J.
Physiol. 271: E636-642, 1996.
144. Banks, W.A., L.M. Maness, M.F. Banks, and A.J. Kastin. Aluminum-sensitive
degradation of amyloid ß-protein1-40 by murine and human intracellular enzymes.
Neurotoxicology and Teratology 18:671-677, 1996.
145. Banks, W.A., A.J. Kastin, L.M. Harrison, and J.E. Zadina. Perinatal treatment of rats
with opiates affects the development of the blood-brain barrier transport system PTS-1.
Neurotoxicology and Teratology 18:711-715,1996.
146. Banks, W.A., D. Uchida, A. Arimura, A. Somogyvári-Vigh, and S. Shioda. Transport
of pituitary adenylate cyclase-activating polypeptide across the blood-brain barrier and
the prevention of ischemia-induced death of hippocampal neurons. In: VIP, PACAP, and
Related Peptides: Second International Symposium, A. Arimura and S. I. Said (Eds.)
Ann. NY Acad. Sci. 805: 270-279, 1996.
147. Banks, W.A., A.J. Kastin, and S.I. Rapoport. Permeability of the blood-brain barrier
to circulating free fatty acids. In: Handbook of Essential Fatty Acid Biology:
Biochemistry,Physiology, and Behavioral Neurobiology, S. Yehuda and D.I. Mostofsky
(Eds.) Humana Press, Totowa, NJ, 3-14, 1997.
148. Banks, W.A., M.B. Fasold, and A.J. Kastin. Measurement of efflux rates from brain to
blood. In: Methods in Molecular Biology: Neuropeptide Protocols, G.B. Irvine and C.H.
Williams (Eds.), Humana Press, Totowa, NJ, 353-360, 1997.
42
149. Shayo, M., R.N. McLay, A.J. Kastin, and W.A. Banks. The putative blood-brain barrier
transporter for the ß-amyloid binding protein apolipoprotein J is saturated at
physiological levels. Life Sciences 60: PL115-118,1997.
150. Plotkin, S.R., W.A. Banks, P.J. Waguespack, and A.J. Kastin. Ethanol alters brain Metenkephalin
in mice by affecting peptide transport system-1 independent of
preproenkephalin mRNA. J. Neurosci. Res. 48: 273-280, 1997.
151. Martins, J.M, W.A. Banks, and A.J. Kastin. Acute modulation of the active carriermediated
brain to blood transport of corticotropin-releasing hormone. Am. J. Physiol.
272:E312-319, 1997.
152. Banks, W.A. and A.J. Kastin. The role of the blood-brain barrier transporter PTS-1 in
regulating concentrations of methionine enkephalin in blood and brain. Alcohol 14:237-
245,1997.
153. Maness, L.M., W.A. Banks, and A.J. Kastin. Investigation of blood-brain barrier
penetration and central nervous system distribution of peptides and proteins by in vivo
autoradiography. S.T.P. Pharma Sciences. 7:12-16,1997.
154. Pan, W., W.A. Banks, and A.J. Kastin. Permeability of the blood-brain and
blood-spinal cord barriers to interferons. J. Neuroimmunol. 76:105-111, 1997.
155. Pan, W., W.A. Banks, and A.J. Kastin. Blood-brain barrier permeability to ebiratide and
TNF in acute spinal cord injury. Experimental Neurology 146: 367-373, 1997.
156. Banks, W.A., A.J. Kastin, and V. Akerstrom. HIV-1 protein gp120 crosses the bloodbrain
barrier: Role of adsorptive endocytosis. Life Sciences 6: PL119-125, 1997.
157. Banks, W.A., A.J. Kastin, L.M. Maness, M.F. Banks, M. Shayo, and R.N. McLay.
Interactions of ß-amyloids with the blood-brain barrier. In: Cerebrovascular Pathology
in Alzheimer’s Disease, J.C. de la Torre and V. Hachinski (Eds.) Ann. NY Acad. Sci.
826: 190-199, 1997.
158. Pan.W. J.E. Zadina, R.E. Harlan, J.T. Weber, W.A. Banks, and A.J. Kastin. Tumor
necrosis factor-alpha: a neuromodulator in the CNS. Neurosci. Biobehav. Rev. 21: 603-
613, 1997.
159. Banks, W.A. and A.J. Kastin. Relative contributions of peripheral and central sources to
levels of IL-1 alpha in the cerebral cortex of mice: assessment with species-specific
enzyme immunoassays. J. Neuroimmunol. 79: 22-28, 1997.
160. Banks, W.A., J.B. Jaspan, and A.J. Kastin. Selective, physiological transport of insulin
across the blood-brain barrier: Novel demonstration by species-specific
radioimmunoassays. Peptides 18: 1257-1262, 1997.
43
161. Banks, W.A., J.B. Jaspan, W. Huang, and A.J. Kastin. Transport of insulin across the
blood-brain barrier: Saturability at euglycemic doses of insulin. Peptides 18: 1423-1429,
1997.
162. McLay, R.N., W.A. Banks, and A.J. Kastin. Granulocyte macrophage-colony stimulating
factor crosses the blood-testis barrier in mice. Biology of Reproduction 87: 822-826,
1997.
163. McLay, R.N., M. Kimura, W.A. Banks, and A.J. Kastin. Granulocyte-macrophage
colony-stimulating factor crosses the blood-brain and blood-spinal cord barrier. Brain
120: 2083-2091, 1997.
164. Banks, W.A., A.J. Kastin, and J.B. Jaspan. Effect of diabetes mellitus on the
permeability of the blood-brain barrier to insulin. Peptides 10: 1577-1584, 1997.
165. Martins, J.M, W.A. Banks, and A.J. Kastin. Transport of CRH from mouse brain directly
affects peripheral penetration of ß-endorphin by the spleen. Am J. Physiol. 273: E1083-
1089, 1997.
166. Kastin, A.J., R.D. Olson, J.M. Martins, G.A. Olson, J.E. Zadina, and W.A. Banks.
Chronic fatigue syndrome: Possible integration of hormonal and immunological
observations. In: Chronic Fatigue Syndrome, S. Yehuda and D.I. Mostofsky (Eds),
Plenum Pres, New York, pp 161-192, 1997.
167. Banks, W.A., A.J. Kastin, and A. Arimura. Effect of spinal cord injury on the
permeability of the blood-brain and blood-spinal cord barriers to the neurotropin PACAP.
Experimental Neurology 151: 116-123, 1998.
168. Pan, W., W.A. Banks, A.J. Kastin. Permeability of the blood-brain barrier to
neurotrophins. Brain Research 788: 87-94, 1998.
169. Kastin, A.J., K. Hahn, J.E. Zadina, and W.A. Banks. Regional differences in metabolism
of Tyr-MIF-1 and Tyr-W-MIF-1 by rat brain mitochondria. Biochem. Pharmacol. 55: 33-
36, 1998.
170. Plotkin, S.R., W.A. Banks, and A.J. Kastin. Enkephalin, PPE mRNA, and PTS-1 in
alcohol withdrawal seizure-prone and -resistant mice. Alcohol 15: 25-31,1998.
171. Banks, W.A. and A.J. Kastin. Differential permeability of the blood-brain barrier to two
pancreatic peptides: Insulin and amylin. Peptides 19: 883-889, 1998.
172. Banks, W.A., A.J. Kastin, and C.A. Ehrensing. Diurnal uptake of circulating interleukin-
1-alpha by brain, spinal cord, testis and muscle. NeuroImmunoModulation 5: 36-41,
1998.
44
173. Banks, W.A., V. Akerstrom, and A.J. Kastin. Adsorptive endocytosis mediates the
passage of HIV-1 across the BBB: Evidence for a post-internalization co-receptor. J.
Cell Sci. 111: 533-540, 1998.
174. Maness, L.M., A.J. Kastin, and W.A. Banks. Relative contributions of a CVO and the
microvascular bed to delivery of blood-borne IL-1 alpha into the brain. Am. J. Physiol.
275:E207-212, 1998.
175. Banks, W.A. and A.J. Kastin. Characterization of lectin-mediated brain uptake of HIV-1
gp120. J. Neurosci. Res. 54:522-529, 1998.
176. Maness, L.M., A.J. Kastin, C.L. Farrell, and W.A. Banks. Fate of leptin after
intracerebroventricular injection into the mouse brain. Endocrinology 139:4556-4562,
1998.
177. Ortiz, L.A., Lasky, J., R.F. Hamilton, Jr., A. Holian, G.W. Hoyle, W. Banks, J.J.
Peschon, A.R. Brody, G. Lungarella, M. Friedman. Expression of TNF and the necessity
of TNF receptors in bleomycin-induced lung injury in mice. Exp. Lung Res. 24: 721-
743, 1998.
178. Ortiz, L.A., K. Moroz, J.Y. Liu, G.W. Hoyle, T. Hammond, R.F. Hamilton, A. Holian,
W. Banks, A.R. Brody, M. Friedman. Alveloar macrophage apoptosis and TNF-alpha,
but not p53, expression correlate with murine response to bleomycin. Am. J. Physiol.
275: L1208-1218, 1998.
179. Pan, W., W.A. Banks, M.B. Fasold, J. Bluth, and A.J. Kastin. Transport of brain-derived
neurotrophic factor across the blood-brain barrier. Neuropharmacology 37:1553-1561,
1998.
180. Kastin, A.J., W.A. Banks, and W. Pan. Peptides and cytokines cross the blood-brain
barrier. (with April 1998 update) In: Encyclopedia of Neuroscience, George Adelman
and Barry H. Smith (Eds.) Elsevier Science BV, New York, NY, pp 1607-1608, 1999.
181. Banks, W.A., A.J. Kastin, J.M. Brennan, K.L. Vallance. Adsorptive endocytosis of HIV-
1gp120 by blood-brain barrier is enhanced by lipopolysaccharide. Experimental
Neurology 156: 165-171, 1999.
182. Cashion, M.F., W.A. Banks, K.L. Bost, and A.J. Kastin. Transmission routes of HIV-1
gp120 from brain to lymphoid tissues. Brain Research 822:26-33, 1999.
183. Ortiz, L.A., J. A. Lasky, G. Lungarella, E. Cavarra, P. Martorana, W.A. Banks, J.J.
Peschon, A.R. Brody, and M. Friedman. Upregulation of the p75 but not the p55 TNF
receptor mRNA during silica and bleomycin-induced lung injury in mice. Am. J. Respir.
45
Cell Mol. Biol. 20: 825-833, 1999.
184. Banks, W.A., R.N. McLay, A.J. Kastin, U. Sarmiento, and S. Scully. Passage of leptin
across the blood-testis barrier. Am. J. Physiol. 276: E1099-1104, 1999.
185. Banks, W.A., F. Ibrahimi, S.A. Farr, J.F. Flood, and J.E. Morley. Effects of wheatgerm
agglutinin and aging on the regional brain uptake of HIV-1gp120. Life Sci. 65: 81-89,
1999.
186. Banks, W.A., A.J. Kastin, and W. Pan. Uptake and degradation of blood-borne insulin
by the olfactory bulb. Peptides 20: 373-378, 1999.
187. Pan, Weihong, A.J. Kastin, W.A. Banks, and J.E. Zadina. Effects of peptides: A crosslisting
of peptides and their central actions published in the journal Peptides from 1994
through 1998. Peptides 20: 1127-1138,1999.
188. Banks, W.A. Characterization of interleukin 1? binding to mouse brain endothelial cells.
J. Pharmacol. Exp. Ther. 291: 665-670, 1999.
189. Mizushima,H., W.A. Banks, K. Dohi, S. Shioda, and K. Matsumoto. Effect of cardiac
arrest on brain weight and the permeability of the blood-brain barrier and blood-spinal
cord barrier to albumin and tumor necrosis factor-?. Life Sciences 65:2127-2134, 1999.
190. Maresh, G.A., A.J. Kastin, T.T. Terry, J.E. Zadina,W.A. Banks. Peptide transport system-
1 (PTS-1) for Tyr-MIF-1 and Met-enkephalin differs from the receptors for either. Brain
Research 839: 336-340, 1999.
191. Mizushima,H., W.A. Banks, K. Dohi, S. Shioda, H. Matsumoto, and K. Matsumoto. The
effect of cardiac arrest on the permeability of the mouse blood-brain barrier and blood
spinal cord barrier to pituitary adenylate cyclase activating polypeptide (PACAP).
Peptides 20: 1337-1340, 1999.
192. Banks, W.A., C.R. DiPalma, and C.L. Farrell. Impaired transport of leptin across the
blood-brain barrier in obesity. Peptides 20: 1341-1345, 1999.
193. Kastin, A.J., W. Pan, L.M. Lawrence, and W. A. Banks. Peptides crossing the bloodbrain
barrier: Some unusual observations. Brain Research 848:96-100, 1999.
194. Banks, W.A. Physiology and pathology of the blood-brain barrier: implications for
microbial pathogenesis, drug delivery and neurodegenerative disorders. J.
NeuroVirology: 5:538-555, 1999.
195. King, L.M., W.A. Banks, and W.J. George. Differences in cadmium transport to the
testis epididymus, and brain in cadmium-sensitive and -resistant murine strains 129/J and
46
A/J. J. Pharmacol. Exp. Ther. 289: 825-830, 1999.
196. Mizushima, H., W.A. Banks, K. Dohi, Y. Nakamura, K. Matsumoto, and S. Shioda.
Functional changes of blood-brain barrier (BBB) after cardiac arrest in mice (Japanese
text with English abstract). Neuroimmunological Research 12:200-203, 1999.
197. Taylor, E.M., D.A. Otero, W.A. Banks, J.S. O’Brien. Designing stable, blood-brain
barrier-permeable ProsaptideTM peptides for treatment of central nervous system
neurodegeneration. J. Pharmacol. Exp. Ther. 293:403-409, 2000.
198. Farr, S.A., W.A. Banks, and J.E. Morley. Estradiol potentiates acetylcholine and
glutamate-mediated post-trial memory processing in the hippocampus. Brain Res. 864:
263-269, 2000.
199. Banks, W.A., C. M. Clever, C. L. Farrell. Partial saturation and regional variation in the
blood-to-brain transport of leptin in normal weight mice. Am. J. Physiol. 278: E1158-
1165, 2000.
200. Farr, S.A., W.A. Banks, M.E. La Scola, J.F. Flood, and J.E. Morley. Permanent and
temporary inactivation of the hippocampus impairs T-maze footshock avoidance
acquisition and retention. Brain Res. 872: 242-249, 2000.
201. Maness, L.M., W.A. Banks, and A.J. Kastin. Persistence of blood-to-brain transport of
leptin in obese leptin-deficient and leptin receptor-deficient mice. Brain Res. 873: 165-
167, 2000.
202. King, L.M., W.A. Banks, and W.J. George. Differential zinc transport into testis and
brain of cadmium-sensitive and -resistant murine strains. J. Andrology 21:656-663, 2000
203. Banks, W.A. and J.E. Morley. Endocrine and metabolic changes in human aging. Age
23: 103-115, 2000.
204. Banks, W.A. Protector, prey, or perpetrator: The pathophysiology of the blood-brain
barrier in NeuroAIDS. Science Online: NeuroAids Vol 3 (issue 3) May 2000,
www.sciencemag.org/NAIDS.
205. Taylor, E.M., D.A. Otero, W.A. Banks, and J.S. O’Brien. Retro-inverse Prosaptide
peptides retain bioactivity, are stable in vivo, and are blood-brain barrier permeable. J.
Pharmacol. Exp.Ther. 295: 190-194, 2000.
206. Plotkin, S.R., W.A. Banks, L.M. Maness, and A.J. Kastin. Differential transport of rat
and human interleukin-1apha across the blood-brain barrier and blood-testis barrier in
rats. Brain Res. 881:57-61, 2000.
47
207. Banks, W.A., S.A. Farr, and J.E. Morley. Permeability of the blood-brain barrier to
albumin and insulin in the young and aged SAMP8 mouse. J. Gerontology 55A: B601-
B606, 2000.
208. Banks, W.A. The aged blood-brain barrier: A substrate for CNS disease. In: The Science
of Geriatrics, J.E. Morley, H.J. Armbrecht, R.M. Coe, B. Vellas (Eds.), Serdi Publisher,
Springer Publishing Co, New York, NY, pp 521-530, 2000.
209. Kumar, V.B., S.A. Farr, J.F. Flood, V. Kamlesh, M. Franko, W.A. Banks, and J.E.
Morley. Site-directed antisense oligonucleotide decreases the expression of amyloid
precursor protein and reverses deficits in learning and memory in aged SAMP8 mice.
Peptides 21:1769-1775, 2000.
210. Moinuddin, A., J.E. Morley, and W.A. Banks. Regional variations in the transport of
interleukin-1 alpha across the blood-brain barrier in ICR and aging SAMP8 mice.
Neuroimmunomodulation 8:165-170, 2000.
211. Mizushima, H., W. Banks, K. Dohi, Y. Nakamura, K. Matsumoto, and S. Shioda. The
effect of cardiac arrest on the permeability of the mouse blood-brain and blood-spinal
cord barriers to PACAP. In: VIP, PACAP, Glucagon, and Related Peptides. Ann. NY
Acad. Sci. 921: 289-292, 2001.
212. Banks, W.A. Cytokines, CVOs, and the blood-brain barrier. In: Psychoneuroimmunology
(3rd edition), Chapter 18. Robert Ader, David Felton, Nicholas Cohen (Eds.) Academic
Press, p483-497, 2001.
213. Banks,W.A. Leptin transport across the blood-brain barrier: Implications for the cause
and treatment of obesity. Current Pharmaceutical Design. 7:125-133, 2001.
214. Mizushima, H., Y. Nakamura, H. Matsumoto, K. Dohi, K. Matsumoto, S. Shioda, and
W.A. Banks. The effect of cardiac arrest on the blood-testis barrier to albumin, tumor
necrosis factor-alpha, pituitary adenylate cyclase activating polypeptide, sucrose, and
verapamil in the mouse. J. Andrology 22: 255-260, 2001.
215. Plotkin, S.R., W.A. Banks, C.S. Cohn, and A.J. Kastin. Withdrawal from alcohol in
withdrawal seizure-prone mice and -resistant mice: Evidence for enkephalin resistance.
Pharmacol. Biochem. Behav. 68: 379-387, 2001.
216. Banks, W.A., E.O. Freed, K.M. Wolf, S.M. Robinson, and V. Kumar. Transport of
human immunodeficiency virus type1 pseudoviruses across the blood-brain barrier: Role
of envelope proteins and adsorptive endocytosis. J. Virology 75: 4681-4691, 2001.
217. Kastin, A.J., W. Pan, J.E. Zadina, and W.A. Banks . The Endocrine Brain. In: Principles
and Practice of Endocrinology and Metabolism, Third Edition , K.L. Becker (Ed.),
48
Lippincott Williams & Wilkins, Philadelphia, PA, pp 1611-1615, 2001.
218. Banks, W.A. Enhanced leptin transport across the blood-brain barrier by alpha1-
adrenergic agents. Brain Res. 899:209-217, 2001.
219. Banks, W.A. Anorectic effects of circulating cytokines: Role of the vascular blood-brain
barrier. Nutrition 17: 434-437, 2001.
220. Banks, W.A., S.A. Farr, W. Butt, V.B. Kumar, M.W. Franco, and J.E. Morley. Delivery
across the blood-brain barrier of antisense directed against amyloid ß: Reversal of
learning and memory deficits in mice overexpressing amyloid precursor protein. J.
Pharmacol. Exp Therap.297: 1113-1121, 2001.
221. Xaio, H., W.A. Banks, M.L. Niehoff, and J.E. Morley. Effect of LPS on the permeability
of the blood-brain barrier to insulin. Brain Res. 896: 36-42, 2001.
222. Ortiz, L.A., M. Friedman, J. Peschon, and W.A Banks. Role of LPS and receptor
subtypes in the uptake of TNF by murine lung. Life Sciences 69: 791-802, 2001.
223. Banks, W.A., A. Moinuddin, and J.E. Morley. Regional transport of TNF-alpha across
the blood-brain barrier in young ICR and young and aged SAMP8 mice. Neurobiology
of Aging 22: 671-676, 2001.
224. Banks, W.A., C.L. McMillian, S. Iyengar. Saturable transport of the NK-1 nonpeptide
antagonist LY303870 across the blood-brain barrier after intravenous administration. Life
Sciences 69:1683-1689, 2001.
225. Banks, W.A., J.E. Phillips-Conroy, C.J. Jolly, and J.E. Morley. Serum leptin levels in
wild and captive populations of baboons (Papio): Implications for the ancestral role of
leptin. J. Clin. Endocrinol. Metab. 86:4315-4320, 2001.
226. Banks, W.A., S.A. Farr, M.E. La Scola, J.E. Morley. Intravenous human interleukin-1
alpha impairs memory processing in mice: Dependence on blood-brain barrier transport
into posterior division of the septum. J. Pharmacol. Exp. Therap. 299:536-541, 2001.
227. Banks, W.A., B.M. King, K.N. Rossiter, R.D. Olson, G.A. Olson, A.J. Kastin. Obesityinducing
lesions of the central nervous system alter leptin uptake by the blood-brain
barrier. Life Sciences 69:2765-2773, 2001.
228. Morley, J.E., S.A. Farr, V.B. Kumar, and W.A. Banks. Alzheimer’s disease through the
eye of a mouse. Acceptance lecture for the 2001 Gayle A Olson and Richard D. Olson
Prize. Peptides 23:589-599, 2002.
229. Hileman, S.M., D.D. Pierroz, H. Masuzaki, C. Bjørbæk, K. el-Haschimi, W.A. Banks,
49
J.S. Flier. Characterization of short isoforms of the leptin receptor in rat cerebral
microvessels and of leptin uptake in mouse models of obesity. Endocrinology 143:775
783, 2002.
230. Banks, W.A. and C.P. LeBel. Strategies for the delivery of leptin to the CNS. J. Drug
Targeting 10:297-308, 2002.
231. McCarthy, T.J., W.A. Banks, C.L. Farrell, S. Adamu, C.P. Derdyn, A.Z. Snyder, R.
Laforest, D.C. Litzinger, D. Martin, C.P. LeBel, and M.J. Welch. Positron emission
tomography shows that intrathecal leptin reaches the hypothalamus in baboons. J.
Pharmacol. Exp. Therap. 301:878-883, 2002.
232. Banks, W.A., M.L. Niehoff, R.L. Brown, Z.-Y. Chen, and T.E. Cleveland. Transport of
an antifungal trypsin inhibitor isolated from corn across the blood-brain barrier.
Antimicrobial Agents and Chemotherapy 46:2633-2635, 2002.
233. Permanne, B., C. Adessi, G.P. Saborio, S. Fraga, M.-J. Frossard, J. Van Dorpe, I.
Dewachter, W.A. Banks, F. Van Leuven, and C. Soto. Reduction of amyloid load and
cerebral damage in a transgenic mouse model of Alzheimer’s disease by treatment with a
ß-sheet breaker peptide. FASEB J.16:860-862, 2002 & FASEB J. (April 10, 2002)
10.1096/fj.01-0841fje at http://www.fasebj.org/cgi/doi/10.1096/fj.01-0841fje.
234. Banks, W.A., M. Tschöp, S.M. Robinson, and M.L. Heiman. Extent and direction of
ghrelin transport across the blood-brain barrier is determined by its unique primary
structure. J. Pharmacol. Exp. Therap. 302: 822-827, 2002.
235. Banks, M.R. and W.A. Banks. The effects of animal-assisted therapy on loneliness in an
elderly population in long-term care facilities. J. Gerontology 57A: M428-M432, 2002.
236. Jaeger, L.B., S.A. Farr, W.A. Banks, and J.E. Morley. Effect of orexin-A on memory
processing. Peptides 23: 1683-1688, 2002.
237. Farr, S.A., W.A. Banks, M.E. La Scola, and J.E. Morley. Blind mice are not impaired in
T-maze footshock avoidance acquisition and retention. Physiol. & Behav. 76:531-8,
2002.
238. Banks,W.A., M. Goulet, J.R. Rushe, M.L Niehoff, R. Boismenu. Differential transport of
a secretin analog across the blood-brain and blood-cerebrospinal fluid barriers of the
mouse. J. Pharmacol. Exp. Therap. 302: 1062-1069, 2002.
239. Banks, W.A., M.L. Niehoff, D. Martin, and C.L. Farrell. Leptin transport across the
blood-brain barrier of the Koletsky rat is not mediated by a product of the leptin receptor
gene. Brain Research 950: 130-136, 2002.
50
240. Didier, N., W.A. Banks, C. Creminon, N. Dereuddre-Bosquet, and A. Mabondzo.
HIV-1-induced production of endothelin-1 in an in vitro model of the human blood-brain
barrier. NeuroReport, 13: 1179-1183, 2002.
241. Farr, S.A., W.A. Banks, K. Uezu, E.O. Freed, V.B. Kumar, and J.E. Morley. Mechanisms
of HIV-1 type 1-induced cognitive impairment: Evidence for hippocampal cholinergic
involvement with overstimulation of the VIPergic system by the viral coat protein core.
AIDS Research and Human Retroviruses.18: 1189-1195, 2002.
242. Miller, G.E., C. A. Stetler, R.M. Carney, K.E. Freedland, and W.A. Banks. Clinical
depression and inflammatory risk markers for coronary heart disease. Am. J. Cardiology
90: 1279-1283, 2002.
243. Nonaka, N., W.A. Banks, H. Mizushima, S. Shioda, J.E. Morley. Regional differences in
PACAP transport across the blood-brain barrier: A possible influence of strain, amyloid ß
protein, and age. Peptides 23: 2197-2202, 2002.
244. Banks, W.A., B. Terrell, S.A. Farr, S.M. Robinson,. N. Nonaka, and J.E. Morley.
Passage of amyloid ß protein antibody across the blood-brain barrier in a mouse model of
Alzheimer’s disease. Peptides 23: 2223-2226, 2002.
245. Banks, W.A. and M.R. Banks. Putting more heart in the nursing home: What we learned
from the dogs. Geriatrics & Aging 6:66, 2003.
246. Farr, S.A., H.F. Poon, D. Dogrukol-Ak, J. Drake, W.A. Banks, E. Eyerman, D.A.
Butterfield, J.E. Morley. The antioxidants alpha-lipoic acid and N-acetylcysteine reverse
memory impairment and brain oxidative stress in aged SAMP8 mice. J. Neurochem.
84:1173-1183, 2003.
247. Banks, W.A. Is obesity a disease of the blood-brain barrier? Physiological, pathological,
and evolutionary considerations. Current Pharmaceutical Design. 9:801-809, 2003.
248. Banks, W.A. and J.E. Morley. Memories are made of this: Recent advances in
understanding cognitive impairments and dementia. J. Gerontology 58A: M314-21, 2003.
249. Banks, W.A., J. Altmann, R.M. Sapolsky, J.E. Phillips-Conroy, and J.E. Morley. Serum
leptin levels as a marker for a Syndrome X-like condition in wild baboons. J. Clin.
Endocrinol. Metab. 88: 1234-40, 2003.
250. Dogrukol-Ak,D., W.A. Banks, N. Tuncel, M. Tuncel. Passage of vasoactive intestinal
peptide across the blood-brain barrier. Peptides 24: 437-444, 2003.
251. Farr, S.A., W.A. Banks, K. Uezu, and J.E. Morley. Antibody to ß-amyloid protein
increases acetylcholine in the hippocampus of 12 month SAMP8 male mice. Life
51
Sciences 73: 555-562, 2003.
252. Banks, W.A. and C.L. Farrell. Impaired transport of leptin across the blood-brain barrier
in obesity is acquired and reversible. Am J. Physiol. 285: E10-E15, 2003.
253. Adessi, C., M.-J. Frossard, C. Boissard, S. Fraga, S. Bieler, T. Ruckle, F. Vilbois, S.M.
Robinson, M. Mutter, W.A. Banks, C. Soto. Pharmacological profiles of peptide drug
candidates for the treatment of Alzheimer’s disease. J. Biol. Chem. 278: 13908-11, 2003.
PMID: 12578830
254. Banks, W.A. Preface to Special Issue “The Blood Brain Barrier in Health and Disease”.
Current Pharmaceutical Design. 9:i-ii, 2003.
255. Miller, G.E., K.E. Freedland, R.M. Carney, C. A. Stetler, and W.A. Banks. Pathways
linking depression, adiposity, and inflammatory markers in healthy young adults. Brain,
Behavior, & Immunity 17: 276-285, 2003.
256. Banks, W.A., S.A. Farr, and J.E. Morley. Entry of blood-borne cytokines into the central
nervous system: Effects on cognitive processes. NeuroImmunoModulation 10: 319-327,
2003.
257. Gaskin, F.S., S.A. Farr, W.A. Banks, V.B. Kumar, and J.E. Morley. Ghrelin-induced
feeding is dependent on nitric oxide. Peptides 24: 913-918, 2003.
258. During, M.J., L. Cao, D.S. Zuzga, J.S. Francis, H.L. Fitzsimons, X. Jiao, R.J. Bland, M.
Klugmann, W.A. Banks, D.J. Ducker, and C.N. Haile. Glucagon-like peptide-1 receptor
is involved in learning and neuroprotection. Nature Medicine 9:1173-1179, 2003. PMID:
12925848
259. Nonaka, N., S. Shioda, M.L. Niehoff, and W.A. Banks. Characterization of blood-brain
barrier permeability to PYY3-36 in the mouse. J. Pharmacol. Exp. Therap. 306: 948-953,
2003.
260. Banks,W.A., S.M. Robinson, S. Verma, and J.E. Morley. Efflux of human and mouse
amyloid ß proteins 1-40 and 1-42 from brain: Impairment in a mouse model of
Alzheimer’s disease. Neuroscience 121:487-492, 2003.
261. Miller, G.E., K.E. Freedland, R.M. Carney, C. A. Stetler, and W.A. Banks. Cynical
hostility, depressive symptoms, and the expression of inflammatory risk markers for
coronary heart disease. J. Behavioral Med. 26: 501-515, 2003.
262. Banks, W.A., K.M. Wolf, and M.L. Niehoff. Effects of chronic ethanol on brain and
serum level of methionine enkephalin. Peptides 24: 1935-1940, 2003.
52
263. Banks, W.A. Neuroimmune networks and communication pathways: The importance of
location. Brain, Behavior, & Immunity 18: 120-122, 2004.
264. Banks, W.A. Role of the blood-brain barrier in communication between the central
nervous system and the peripheral tissues. In: Blood-Spinal Cord and Brain Barriers in
Health and Disease, H.S. Sharma and J. Westman (Eds.) Elsevier, Amsterdam, pp 73-81,
2004.
265. Banks, W.A. Mechanisms of antisense transport across the blood-brain barrier. In:
Blood-Spinal Cord and Brain Barriers in Health and Disease, H.S. Sharma and J.
Westman (Eds.) Elsevier, Amsterdam, pp 99-105, 2004.
266. Levin, B.E., A.A. Dunn-Meynell, and W.A. Banks. Obesity-prone rats have normal
blood-brain barrier transport but defective central leptin signaling before obesity onset.
Am J. Physiol. R143-R150, 2004.
267. Banks, W.A. Commentary: On Insulin Resistance, Affective Disorders and Alzheimer’s
Disease: Review and Hypothesis. J. Gerontology 59A: 184-5, 2004.
268. Morley, J.E., W.A. Banks, V.B. Kumar, and S.A. Farr. The SAMP8 mouse as a model
for Alzheimer’s disease: Studies from Saint Louis University. The Senescence-
Accelerated Mouse (SAM): An Animal Model of Senescence, Y. Nomura, T. Takeda,
and Y. Okuma (Eds.), International Congress Series 1260:23-28, 2004.
269. Banks, W.A. The source of cerebral insulin. European J. of Pharmacol. 490:5-12, 2004.
270. Banks, W.A. Preface to Special Issue “The Blood Brain Barrier in Health and Disease”.
Current Pharmaceutical Design 10:i, 2004.
271. Banks, W.A. Are the extracellular pathways a conduit for the delivery of therapeutics to
the brain? Current Pharmaceutical Design 10:1365-1370, 2004. (Republished in
Frontiers in Medicinal Chemistry 3: 153-61, 2006).
272. Banks, W.A., M.J. During, and M.L. Niehoff. Brain uptake of glucagon-like peptide-1
antagonist exendin(9-39) after intranasal administration. J. Pharmacol. Exp. Therap.
309:469-475, 2004.
273. Banks, W.A. The many lives of leptin. Peptides 25:331-338, 2004.
274. Banks, W.A., M.L. Niehoff, C. Adessi, C. Soto. Passage of murine scrapie prion protein
across the mouse vascular blood-brain barrier. Biochem. Biophys. Res. Comm. 318:125-
130, 2004.
275. Banks, W.A., A.B. Coon, S.M. Robinson, A. Moinuddin, J.M. Shultz, R. Nakaoke, J.E.
53
Morley. Triglycerides induce leptin resistance at the blood-brain barrier. Diabetes
53:1253-1260, 2004. PMID 15111494
276. Jaeger, L.B. and W.A. Banks. Antisense therapeutics and the treatment of CNS disease.
Frontiers in Bioscience 9:1720-27, 2004.
277. Banks, W.A. and S.A. Farr. Anti-Aging methods and medicines for the memory. Clinics
in Geriatric Medicine, J.H. Flaherty and J.E. Morley (Guest Eds.) 20(2): 318-328, 2004.
278. Banks, W.A., V.B. Kumar, and J.E. Morley. Influence of ethanol dependence and
methionine enkephalin antisense on serum endomorphin-1 and methionine enkephalin
levels. Alcoholism: Clinical and Experimental Research 28: 792-796, 2004.
279. Banks, W.A., M.L. Niehoff, and S.S. Zalcman. Permeability of the mouse blood-brain
barrier to murine interleukin-2: Predominance of a saturable efflux system. Brain,
Behavior, & Immunity 18: 434-42, 2004.
280. Poon, H.F., A. Castegna, S.A. Farr, V. Thongboonkerd, B.C. Lynn, W.A. Banks, J.E.
Morley, J.B. Klein, and D.A. Butterfield. Quantitative proteomics analysis of specific
protein expression and oxidative modification in aged senescence-accelerated-prone
mouse brains. Neuroscience 126:915-926, 2004.
281. Nonaka, N., S.M. Hileman, S. Shioda, T.Q. Vo, and W.A. Banks. Effects of
lipopolysaccharide on leptin transport across the blood-brain barrier. Brain Research
1016:58-65, 2004.
282. Urayama, A., J.H. Grubb, W.S. Sly, and W.A. Banks. Developmentally regulated
mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the
blood-brain barrier. Proc. Natl. Acad. Sci. USA 101: 12658-63, 2004.
283. Poon, H.F., J. Gururaj, Sultana, R., S.A. Farr, W.A. Banks, J.E. Morley, V. Calabrese,
D.A. Butterfield. Antisense directed at the Aß region of APP decreases oxidative
markers in brain of an aged senescence accelerated mouse. Brain Res. 1018: 86-96,
2004.
284. Banks, W.A., S.M. Robinson, K.M. Wolf, J.W. Bess, Jr., and L.O. Arthur. Binding,
internalization, and membrane incorporation of human immunodeficiency virus-1 at the
blood-brain barrier is differentially regulated. Neuroscience 128:143-153, 2004.
285. Jaeger, L.B. and W.A. Banks. Transport of antisense across the blood-brain barrier. In:
Methods in Molecular Medicine, Vol 106: Antisense Therapeutics, 2nd edition, ed. M.I.
Phillips, Humana Press, Totowa, New Jersey, p237-251, 2004.
286. Farr, S.A., W.A. Banks, K. Uezu, F.S. Gaskin and J.E. Morley. DHEAS improves
54
learning and memory in aged SAMP8 mice but not in diabetic mice. Life Sciences 75:
2775-2785, 2004.
287. Banks, W.A., N.L. Jumbe, C.L. Farrell, M.L. Niehoff, and A.C. Heatherington. Passage
of erythropoeitic agents across the blood-brain barrier: A comparison of human and
murine erythropoetin and the analog darbepoetin alfa. European Journal of Pharmacology
505: 93-101, 2004.
288. Banks, W.A., P.Pagliari, R. Nakaoke, and J.E. Morley. Effects of a behaviorally active
antibody on the brain uptake and clearance of amyloid beta proteins. Peptides 26: 287-
294, 2005.
289. Nonaka, N., S. Shioda, W.A. Banks. Effect of lipopolysaccharide on the transport of
pituitary adenylate cyclase activating polypeptide across the blood-brain barrier.
Experimental Neurology 191:137-144, 2005.
290. Poon, H.F., S.A. Farr, V. Thongboonkerd, B. Lynn, W.A. Banks, J.E. Morley, J.B. Klein,
and D.A. Butterfield. Proteomic analysis of specific proteins in aged SAMP8 mice
treated with alpha-lipoic acid: Implications for aging and age-related neurodegenerative
disorders. Neurochemistry International 46: 159-168, 2005.
291. Banks, W.A. Blood-brain barrier transport of cytokines: A mechanism for
neuropathology. Current Pharmaceutical Design 11:973-984, 2005.
292. Farr, S.A., W.A. Banks, V.B. Kumar, J.E. Morley. Orexin-A-induced feeding is
dependent on nitric oxide. Peptides 26: 759-765, 2005.
293. Nakaoke, R., J.S. Ryerse, M. Niwa, and W.A. Banks. Human immunodeficiency virus
type 1 transport across the in vitro mouse brain endothelial cell monolayer. Experimental
Neurology 193: 101-109, 2005
294. Banks, W.A., S.M. Robinson, A. Nath. Permeability of the blood-brain barrier to HIV-1
Tat. Experimental Neurology 193: 218-227, 2005.
295. Banks, W.A. The blood-brain barrier: Its structure and function. In: The Neurology of
AIDS 2nd Edition. H.E. Gendelman, I. Grant, I.P. Everall, S.A. Lipton, S. Swindells
(eds). Oxford University Press, Oxford, p107-113, 2005.
296. Price, T.O, Ercal, N, Nakaoke, R., and W.A. Banks. HIV-1 viral proteins gp120 and Tat
induce oxidative stress in brain endothelial cells. Brain Research 1045:57-63, 2005.
297. Nakaoke, R and W.A. Banks. In vitro methods in the study of viral and prion
permeability across the blood-brain barrier. Cellular and Molecular Neurobiology
25:171-180, 2005.
55
298. Batrakova, E.V., S.V. Vinogradov, S.M. Robinson, M.L. Niehoff, W.A. Banks, and A.V.
Kabanov. Polypeptide point modifications with fatty acids and amphipilic block
Copolymers for enhanced brain delivery. Bioconjugate Chemistry 16:793-802, 2005.
299. Farr, S.A., J.F. Scherrer, W.A. Banks, J.F. Flood, J.E. Morley. Chronic ethanol
consumption impairs learning and memory after cessation of ethanol. Alcoholism:
Clinical and Experimental Research 29:971-982, 2005.
300. Jaeger, L.B., W.A. Banks, J.L. Varga, and A.V. Schally. Antagonists of growth
hormone-releasing hormone cross the blood-brain barrier: A potential applicability to
treatment of brain tumors. Proc. Natl. Acad. Sci. USA 102:12495-12500, 2005. PMID:
16118272
301. Banks, W.A., N. Nonaka, S. Shioda, R. Nakaoke, and J.E. Morley. Leptin, insulin and
blood-brain barrier relations in obesity. In: The Metabolic Syndrome at the Beginning of
the XX1st Century: A Genetic and Molecular Approach. M.S. Rios, J.F. Caro, R.
Carrora, J.A.Gutierrez Fuentes (eds), Elsevier, Madrid, p200-215, 2005.
302. Poon, H.F., S.A. Farr, W.A. Banks, W.M. Pierce, J.B. Klein, J.E. Morley, and
Butterfield. Proteomic identification of less oxidized brain proteins in aged senescenceaccelerated
mice following administration of antisense oligonucleotide directed at the Aß
region of amyloid precursor protein. Mol. Brain Res. 138:8-16, 2005.
303. Urayama, A. and W.A. Banks. Effects of stress and nutrition on blood-brain barrier
functions. In: Nutrients, Stress, and Medical Disorders. S. Yehuda and D.I. Mostofsky
(eds), Humana Press, Totowa, NJ, p83-95, 2005.
304. S. Penugonda, S. Mare, G. Goldstein, W.A. Banks, and N. Ercal. Effects of N
acetylcysteine amide (NACA), a novel thiol antioxidant against glutamate-induced
cytotoxicity in neuronal cell line PC12. Brain Research 1056: 132-138, 2005.
305. Banks, W.A., V.B. Kumar, M.W. Franko, J.W. Bess, Jr., and L.O. Arthur. Evidence that
the species barrier of human immunodeficiency virus-1 does not extend to uptake by the
blood-brain barrier: Comparison of mouse and human brain microvessels. Life Sciences
77: 2361-8, 2005.
306. Banks, M.R. and W.A. Banks. The effects of group and individual animal-assisted
therapy on loneliness in residents of long-term care facilities. Anthrozoos 18: 396-408,
2005.
307. Banks, W.A. Critical roles of efflux systems in health and disease. In: Efflux
Transporters and the Blood-Brain Barrier. E.M. Taylor (ed), Nova Science Publishers,
p21-53, 2005.
56
308. Morley, J.E., M.J. Kim, M.T. Haren, R. Kevorkian, and W.A. Banks. Frailty and the
aging male. Aging Male 8:135-140, 2005.
309. Lim, W.S. and W.A. Banks. Other Dementias. In: Principles and Practice of Geriatric
Medicine, 4th edition, eds M.S.J. Pathy, A.J. Sinclair, J.E. Morley. John Wiley & Sons,
p1111-1133, 2006.
310. Banks, W.A., L.B. Jaeger, A. Urayama, V.B. Kumar, S.M. Hileman, F.S. Gaskin, N.V.
Llanza, S.A. Farr, and J.E. Morley. Preproenkephalin targeted antisenses cross the
blood-brain barrier to reduce brain methionine enkephalin levels and increase voluntary
ethanol drinking.Peptides 27: 784-796, 2006.
http://dx.doi.org/10.1016/j.peptides.2005.09.001
311. Spranger, J., S. Verma, I. Gohring, T. Bobbert, J. Seifert, A.L. Sindler, A. Pfeiffer, S.M.
Hileman, M. Tschop, and W.A. Banks. Adiponectin does not cross the blood-brain
barrier, but modifies cytokine expression of brain endothelial cells. Diabetes 55: 141
-147, 2006. PMID 16380487
312. Diano,S., S.A. Farr, S.C. Benoit, E.C. McNay, I. daSilva, B. Horvath, F.S. Gaskin, N.
Nonaka, L.B. Jaeger, W.A. Banks, J.E. Morley, S. Pinto, R.S. Sherwin, L.Xu, K.A.
Yamada, M.W. Sleeman, M.H. Tschop, and T.L. Horvath. Ghrelin controls hippocampal
Spine synapse density and memory performance. Nature Neuroscience 9: 381-388, 2006.
http://dio:10.1038/nn1656
313. Farr, S.A., W.A. Banks, and J.E. Morley. Effects of leptin on memory processing.
Peptides 27:1420-5, 2006. doi:10.1016/j.peptides.2005.10.006.
314. Banks, W.A. and W.S. Lim. Insulin and the blood-brain barrier. In: Blood-brain
Barriers: From Ontogeny to Artificial Barriers, Volume 1. (Eds. R. Dermietzel, D. Spray,
Nedergaard) Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. p265-285, 2006.
315. Banks, W.A. Denial vs Dualism: The blood-brain barrier as an interface of the gut-brain
axis. (Invited editorial) Endocrinology 147: 2609-2610, 2006.
316. Banks, W.A., N. Nonaka, S.A. Farr, and J.E. Morley. Chapter 91: Alzheimer’s disease
and the microcirculation. In: Encyclopedia of the Microvasculature, D. Shepro (ed),
Elsevier Science, pp605-608, 2006.
317. Banks, W.A, S.A. Farr, and J.E. Morley. The role of the blood-brain barrier in feeding:
Leptin. In: Breathing, Feeding, and Neuroprotection. (S. Shioda and I. Homma, Eds).
Springer-Verlag, Tokyo, pp27-37, 2006.
318. Banks, W.A., S.A. Farr, and J.E. Morley. The effects of high fat diets on the blood-brain
57
barrier transport of leptin: Failure or adaptation? Physiol. & Behav. 88:244-248, 2006.
319. Banks, W.A., N. Ercal, and T.O. Price. The blood-brain barrier in neuroAIDS. Current
HIV Research. 4: 259-266, 2006.
320. Banks, WA. Blood-brain barrier in psychoneuroimmunology. Neurological Clinics 24:
413-419, 2006. (G.G. Freund., Ed) Eslevier (Reprinted in Immunology and Allergy
Clinics of North America 29: 223-8, 2009).
321. Banks, W.A. and L. R. Watkins. Mediation of chronic pain: Not by neurons alone.
(Invited editorial) Pain 124:1-2, 2006. http://dx.doi.org/10.1016/j.pain.2006.03.001.
322. Urayama, A., K. King, F.S. Gaskin, S.A. Farr, and W.A. Banks. Effects of chronic
ethanol administration on brain interstitial fluid levels of methionine-enkephalin as
measured by microdialysis in vivo. Peptides 27:2201-2206, 2006.
http://doi:10.1016/j.peptides.2006.03.024
323. Verma, S., R. Nakaoke, S. Dohgu, and W.A. Banks. Release of cytokines by brain
endothelial cells: A polarized response to lipopolysaccharide. Brain, Behavior, &
Immunity 20:449-455, 2006. doi:10.1016/j.bbi.2005.10.005
324. Price, T.O., F. Uras, W.A. Banks, and N. Ercal. A novel antioxidant N-acetylcysteine
amide prevents gp120- and Tat-induced oxidative stress in brain endothelial cells.
Experimental Neurology 201: 193-202, 2006.
325. Banks, W.A., M.L. Niehoff, D. Drago, and P. Zatta. Aluminum complexing enhances
amyloid ß protein penetration of blood-brain barrier. Brain Research 1116: 215-21,
2006. PMID: 16942756
326. Banks, W.A. The blood-brain barrier as a regulatory interface in the gut-brain axes.
Physiol. Behav. 89: 472-6, 2006. PMID: 16904139
327. Banks, W.A. Toward better time: The period of improving animal models in the quest for
the treatment of disease. Critical Care Medicine 34: 2865-6, 2006. PMID: 17053581
328. Rolland, Y.M., H.M. Perry III. P. Patrick, W.A. Banks, and J.E. Morley. Leptin and
adiponectin levels in middle-aged postmenopausal women: Associations with lifestyle
habits, hormones, and inflammatory markers-a cross-sectional study. Metabolism 55:
1630-36, 2006. PMID: 17142136
329. Banks, W.A. Editorial Focus: The Dam Breaks: Disruption of the blood-brain barrier in
diabetes mellitus. Am. J. Physiol. 291: H2595-6, 2006. PMID 16877556
330. Banks, W.A. The CNS as a target for peptides and peptide-based drugs. Expert Opinion
58
on Drug Delivery 3: 707-712, 2006. PMID: 17076593
331. Banks, W.A., R. Nakaoke, A. Urayama, and T.Q. Vo. Chapter 203. Ingestive peptides
and the blood-brain barrier. In: Handbook of Biologically Active Peptides. (A.J. Kastin
and W. Pan, Eds). Elsevier, Amsterdam, pp1455-1459, 2006.
332. Banks, W.A. Chapter 206. Diseases mediated by the BBB: From Alzheimer’s disease to
obesity. In: Handbook of Biologically Active Peptides. (A.J. Kastin and W. Pan, Eds).
Elsevier, Amsterdam, pp1475-1479., 2006.
333. Banks, W.A. The blood-brain barrier and energy balance. Obesity 2006 14 (Suppl 5):
234S-237S. PMID: 17021373
334. Penugonda, S., S. Mare, P. Lutz, W.A. Banks, and N. Ercal. Potentiation of lead-induced
cell death in PC12 cells by glutamate: Protection by N-acetylcysteine amide (NACA), a
novel thiol antioxidant. Toxicol. Appl. Pharmacol. 216: 197-205, 2006.
335. Rolland,Y.M., H.M. Perry III, P. Patrick, W.A. Banks, J.E. Morley. Loss of appendicular
muscle and loss of muscle strength in young postmenopausal women. J. Gerontol. Med
Sci. 62: 330-335, 2007. PMID: 17389732
336. Quan, N. and W.A. Banks. Brain-Immune Communication Pathways (Named Series:
Twenty Years of Brain, Behavior, and Immunity). Brain, Behavior, & Immunity 21:
727-35, 2007. PMID: 17604598
337. Rolland, Y.M., M.T. Haren, P. Patrick, W.A. Banks, T. K. Malmstrom, D.K. Miller,
J.E. Morley. Adiponectin levels in obese and non-obese middle-aged African-American
women. Obesity Res. & Clin. Practice 1:27-37, 2007.
338. Rolland, Y., V. Lauwers-Cances, C. Cristini, H. Grandjean, W.A. Banks, J.E. Morley, B.
Vellas. Disability in obese elderly women: lower lib strength and recreational
physical activity. Obesity Res. & Clin. Practice 1: 39-51, 2007.
339. Banks, W.A., S.A. Farr, J.E. Morley, K.M. Wolf, V. Geylis, and M. Steinitz. Antiamyloid
beta protein antibody passage across the blood-brain barrier in the SAMP8
mouse model of Alzheimer’s disease: An age-related selective uptake with reversal of
learning impairment. Experimental Neurology 206: 248-56, 2007.
doi:10.1016/j.expneurol.2007.05.005; PMID: 17582399
340. Urayama, A., J.H. Grubb, W.A. Banks, and W.S. Sly. Epinephrine enhances lysosomal
enzyme delivery across the blood-brain barrier by up-regulation of the mannose 6-
phosphate receptor. Proc. Natl. Acad. Sci. USA 104: 12873-78, 2007.
DOI:10.1073/pnas.0705611104; PMID: 17646643
59
341. Haren, M.T., T.K. Malmstrom, W.A. Banks, P. Ping, D.K. Miller, and J.E. Miller. Lower
serum DHEAS levels are associated with a higher degree of physical disability and
depressive symptoms in middle-aged to older African American women. Maturitas 57:
347-60, 2007. PMID: 17451893
342. Thomas, D.R., K. Marren, W. Banks, and J. Morley. Do objective measurements of
physical function in ambulatory nursing home women improve assessment of functional
status? J Am Med Dir Assoc 8: 469-76, 2007.
343. Banks, W.A., L. Willoughby, D. Thomas, and J.E. Morley. Insulin resistance syndrome
in the elderly: Assessment of functional, biochemical, metabolic, and inflammatory
status. Diabetes Care 30:2369-2373, 2007. PMID: 17536070
344. Petursdottir, A.L. S.A. Farr, J.E. Morley, W.A. Banks, and G.V. Skuladottir. Lipid
peroxidation in brain during aging in the senescence-accelerated mouse (SAM).
Neurobiol of Aging 28: 1170-8, 2007.
345. Mare, M., S. Penugonda, S.M. Robinson, S. Dohgu, W.A. Banks, and N. Ercal. Copper
complexing decreases the ability of amyloid beta peptide to cross the BBB and enter
brain parenchyma. Peptides 28: 1424-32, 2007. PMID: 17580097
346. Price, T.O., W.K. Samson, M.L. Niehoff, and W.A. Banks. Permeability of the blood
brain barrier to a novel satiety molecule nesfatin-1. Peptides 28: 2372-81, 2007. PMID:
18006117
347. Haren, M.T., W.A. Banks, H.M. Perry III, P. Patrick, T. K. Malmstrom, D.K. Miller, and
J.E. Morley. Predictors of serum testosterone and DHEAS in African-American men.
International Journal of Andrology 31:50-59, 2008. PMID: 18190426 PMC2717611
348. Banks, W.A. Chapter 4: The blood-brain barrier: Age and gender differences. In:
Textbook of Men’s Health and Aging, 2nd edition. B. Lunenfeld, L.J.G. Gooren, A.
Morales, J.E. Morley (Eds.), Informa Healthcare Medical Books, Taylor and Francis,
Boca Raton, pp 39-45, 2007.
349. Nakaoke, R., S. Verma, M. Niwa, S. Dohgu, and W.A. Banks. Glucose-regulated bloodbrain
barrier transport of insulin: Pericyte-astrocyte-endothelial cell cross talk.
International Journal of Neuroprotection and Neuroregeneration 3:195-200, 2007.
350. Neuwelt, E., N.J. Abbott, L. Abrey, W.A. Banks, B. Blakley, T. Davis, B. Engelhardt, P.
Grammas, M. Nedergaard, J. Nutt, W. Pardridge, G.A. Rosenburg, Q. Smith, and L.R.
Drewes. Strategies to advance translational research into brain barriers. Lancet
Neurology 7: 84-96, 2008. PMID: 18093565
351. Banks, M.R, L.M. Willoughby, and W.A. Banks. Animal-assisted therapy and loneliness
60
in nursing homes: Use of robotic vs living dogs. Journal of the American Medical
Directors Association 9:173-7, 2008. PMID: 18294600
352. Nonaka, N., S.A. Farr, H. Kageyama, S. Shioda, and W.A. Banks. Delivery of galanin
like peptide to the brain: Targeting with intranasal delivery and cyclodextrins. J.
Pharmacol. Exp. Therap. 325:513-9, 2008. PMID: 18270319
353. Banks, W.A., S. Dohgu, J.L. Lynch, M.A. Fleegal-DeMotta, M.A. Erickson, R. Nakaoke,
and T.Q. Vo. Nitric oxide isoenzymes regulate lipopolysaccharide-enhanced insulin
transport across the blood-brain barrier. Endocrinology 149:1514:1523, 2008. PMID:
18187549 PMC2276709
354. Festuccia, W.T., S. Oztezcan, M. Laplante, M. Berthiaume, C. Michel, S. Dohgu, R.G.
Denis, M.N. Brito, N.A. Brito, D.S. Miller, W.A. Banks, T.J. Bartness, D. Richard, and
Y. Deshaies. Peroxisome proliferative-activated receptor-gamma-mediated positive
energy balance in the rat is associated with reduced sympathetic drive to adipose tissues
and thyroid status. Endocrinology 149:2121-2130, 2008. PMID: 18278698
355. Farr, S.A., K.A. Yamada, D.A. Butterfield, H.M. Abdul, L. Xu, N.E. Miller, W.A. Banks,
and J.E. Morley. Obesity and hypertriglyceridemia produce cognitive impairment.
Endocrinology 149: 2628-36, 2008. PMID: 18276751 PMC2329289
356. Dohgu, S . and W.A. Banks. Lipopolysaccharide-enhanced transcellular transport of
HIV-1 across the blood-brain barrier is mediated by the p38 mitogen-activated protein
kinase pathway. Experimental Neurology 210: 740-9, 2008,
http://dx.doi.org/10.1016/j.expneurol.2007.12.028 PMID:18295207 PMC2385783
357. Yi, X., E. Batrakova, W.A. Banks, S. Vinogradov, and A.V. Kabanov. Protein
conjugation with amphiphilic block copolymers for enhanced cellular delivery.
Bioconjug. Chem. 19: 1071-7, 2008. PMID: 18447367 PMC2570949
358. Banks, W.A. Editorial: The blood-brain barrier as a cause of disease. Current
Pharmaceutical Design 14: 1553-1554, 2008. PMID:18673196
359. Banks, W.A. The blood-brain barrier as a cause of obesity. Current Pharmaceutical
Design 14: 1606-1614, 2008. PMID: 18673202
360. Urayama, A and W.A. Banks. Starvation and triglycerides reverse the obesity-induced
impairment of insulin transport at the blood-brain barrier. Endocrinology 149:3592-97,
2008. DOI: 10.1210/en.2008-0008. PMID:18403490 PMC2453080
361. Urayama, A., J.H. Grubb, W.S. Sly, and W.A. Banks. Mannose 6-phosphate-receptor
mediated transport of sulfamidase across the blood-brain barrier in the newborn mouse.
Molecular Therapy. 16: 1261-1266, 2008. PMID: 18443601
61
362. Banks, W.A. The blood-brain barrier: Connecting the gut and the brain. Regulatory
Peptides. 149:11-14, 2008. PMID: 18486244 PMC2553040
363. Banks, W.A. The Blood-Brain Barriers: Structure and Function. In: Neuroimmune
Pharmacology. T. Ikezu and H.E. Gendelman (Eds.), Springer, New York, pp21-38,
2008.
364. Banks, W.A. Blood-brain barrier transport of cytokines. In: Neuroimmune Biology, Vol 6,
Cytokines and the Brain. C. Phelps and E. Korneva (Volume Eds.), I. Berczi and A.
Szentivanyi (Editors in Chief), Elsevier, Amersterdam, pp93-107, 2008.
365. Petursdottir, A.L. S.A. Farr, J.E. Morley, W.A. Banks, and G.V. Skuladottir. Effect of
dietary n-3 polyunsaturated fatty acids on brain lipid fatty acid composition, learning
ability, and memory in the senescence-accelerated mouse. Journal of Gerontology:
Biological Sciences 11:1153-60, 2008. PMID: 19038829
366. Banks, W.A., J.L. Lynch, and T.O. Price. Cytokines and the blood-brain barrier. In: The
Neuroimmunological Basis of Behavior and Mental Disorders. Allan Siegel and Steven
S. Zalcman (eds). Springer, New York, pp3-17, 2008.
DOI 10.1007/978-0-387-84851-8_1
367. Lynch, J.L. and W.A. Banks. Opiate modulation of IL-1alpha, IL-2, and TNF-alpha
transport across the blood-brain barrier. Brain, Behavior, & Immunity. 22: 1096-1102,
2008. DOI 10.1016/j.bbi.2008.04.004; PMID:18502094
368. Banks, W.A. Delivery of Peptides to the Brain: Emphasis on Therapeutic Development.
Biopolymers: Peptide Science 90: 589-594, 2008. DOI 10.1002/bip.20980 PMID:
18335425
369. Banks, W.A. Developing drugs that can cross the blood-brain barrier: Applications to
Alzheimer’s disease. BMC Neuroscience 9 (Suppl 3):S2, p1-4, 2008
DOI:10.1186/1471-9-S3-S2; PMID: 19090999 PMC2604887
370. Banks, W.A., B.O. Burney, S.M. Robinson. Effects of Triglycerides, Obesity, and
Starvation on Ghrelin Transport Across the Blood-Brain Barrier. Peptides 29: 2061-
2065, 2008. PMID: 18682266 PMC2586070
371. Dogrukol-Ak, D., V.B. Kumar, J.S. Ryerse, S.A. Farr, S. Verma, N. Nonaka, T.
Nakamachi, H. Ohtaki, M.L. Niehoff, J.C. Edward, S. Shioda, J.E. Morley, W.A. Banks.
Delivery of the neuroprotectant pituitary adenylate cyclase activating polypeptide to
brain: Identification and inhibition of its brain-to-blood efflux transporter. J Cereb Blood
Flow and Metab 29:411-22, 2009. PMID: 19002200
62
372. Banks, W.A., J.E. Morley, M.L. Niehoff, and C. Mattern. Delivery of testosterone to the
brain by intranasal administration: Comparison to intravenous testosterone. Journal of
Drug Targeting 17: 91-7, 2009. PMID: 19089688
373. Kumar, V.B., M. Franko, W.A. Banks, P. Kasinadhuni, S.A. Farr, K. Vyas, V.
Choudhuri, J.E. Morley. Increase in presenilin 1 (PS1) levels in senescence accelerated
mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein
(APP) processing. J Expt Biol. 212: 494-8, 2009. PMID: 19181896
374. Fleegal-DeMotta, M., S. Dohgu, W.A. Banks. Angiotensin II modulates BBB
permeability via activation of the AT1 receptor in brain endothelial cells. J. Cereb. Blood
Flow and Metab. 29: 640-7, 2009. PMID 19127280
375. Hawkins P.M., P.A. Jellis, N. Nonaka, X. Shi, W.A. Banks. Permeability of the bloodbrain
barrier to a rhenacarborane. J. Pharmacol. Exp. Therap. 329: 608-614, 2009. PMID
19179541 PMC2672864
376. Banks, W.A., S.M. Robinson, R. Diaz-Espinoza, A. Urayama, C. Soto. Transport of
prion protein across the blood-brain barrier. Experimental Neurology. 218: 162-7, 2009.
PMID: 19422824 PMC2806677
377. Jaeger, L.B., S. Dohgu, R. Sultana, J.L. Lynch, J.L. Owen, M.A. Erickson, G.N. Shah,
T.O. Price, M.A. Fleegal-Demotta, D.A. Butterfield, and W.A. Banks.
Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: A
mechanism for inflammation in the progression of Alzheimer’s disease. Brain, Behavior,
& Immunity 23:507-17, 2009. PMC2783557
378. Zhang, X., A. Banerjee, W.A. Banks, N. Ercal. N-Acetylcysteine amide protects against
methamphetamine-induced oxidative stress and neurotoxicity in immortalized human
brain endothelial cells. Brain Res. 1275: 87-95, 2009. PMID 19374890 PMC2702674
379. Salkeni, M.A., J.L. Lynch, T.O. Price, W.A. Banks. Lipopolysaccharide impairs blood
brain barrier P-glycoprotein function in mice through prostaglandin- and nitric oxide
independent pathways. J Neuroimmune Pharmacology. 4: 276-282, 2009. PMID
19039663 PMC2802264
380. Elinav, E., L. Niv-Spector, M. Katz, T.O. Price, M. Ali, M. Yacobovitz, G. Solomon, S.
Reicher, J. L. Lynch, Z. Halpern, W.A. Banks, A. Gertler. Pegylated leptin antagonist is a
potent orexigenic agent: Preparation and mechanism of activity. Endocrinology 150:
3083-3091, 2009. PMID: 19342450 PMC2703547
381. Banks, W.A.. Characteristics of compounds that cross the blood-brain barrier. Biomed
Central Neurology. 9: Supplement 1:S3, 2009. PMID: 19534732 PMC2697631
63
382. Jaeger, L.B., S. Dohgu, M.C. Hwang, S.A. Farr, M.P. Murphy, M.A. Fleegal-DeMotta, J.
L. Lynch, S.M. Robinson, M.L. Niehoff, S.N. Johnson, V.B. Kumar, W.A. Banks.
Testing the neurovascular hypothesis of Alzheimer’s disease: LRP-1 antisense reduces
blood-brain barrier clearance, increases brain levels of amyloid beta protein, and impairs
cognition. J Alzheimer’s Disease. 17:553-570, 2009. PMID: 19433890 PMC2802833
383. Cheng, F., P.J. McLaughlin, W.A. Banks, I. S. Zagon. Passive diffusion of naltrexone
into human and animal cells and upregulation of cell proliferation. Am J Physiol: Regul
Integr Comp Physiol 297: R844-52, 2009. PMID: 19605761
384. Vergote,V., S. Van Dorpe, M. Verbeken, C. Burvenich, C. Van de Wiele, W.A. Banks,
B. De Spiegeleer. Development of peptide receptor binding assays: Methods to avoid
false negatives. Regulatory Peptides 158: 97-102, 2009. PMID: 19706310
385. Ali, A.K., W.A. Banks, V.B. Kumar, G.N. Shah, J.L. Lynch, S.A. Farr, M.A. Fleegel-
DeMotta, and J.E. Morley. Nitric oxide activity and isoenzyme expression in the
senescence-accelerated mouse P8 model of Alzheimer’s disease: Effects of anti-amyloid
and antisense treatment. J Gerontology: Biol Sci 64: 1025-30, 2009. PMID: 19531769
DOI: 10.1039/gerona/glp074
386. Banks, W.A., M.A. Erickson. The blood-brain barrier and immune function and
dysfunction. Neurobiology of Disease 37: 26-32, 2010. PMID: 19664708
387. Banks, W.A. and S.M. Robinson. Minimal penetration of lipopolysaccharide across the
murine blood-brain barrier. Brain, Behavior, & Immunity 24: 102-109, 2010.
PMID: 19735725 PMC2789209
388. Banks, W.A. The blood-brain barrier as a regulatory interface. In: Frontiers in Eating and
Weight Regulation. W. Langhans and N. Geary (Eds.) S. Karger AG, Basel, Switzerland.
Forum Nutrition 63: 102-110, 2010.
389. Sultana, R., W.A. Banks, D.A. Butterfield. Decreased levels of PSD95 and two
associated proteins and increased levels of BCl2 and Caspase 3 in hippocampus from
subjects with amnestic mild cognitive impairment: Insights into their potential roles for
loss of synapses and memory, accumulation of aß, and neurodegeneration in a prodromal
stage of Alzheimer’s disease. J Neurosci Res.88: 469-77. 2010. PMID: 19774677.
390. Banks, W.A. Immunotherapy and neuroimmunology in Alzheimer’s disease: A
perspective from the blood-brain barrier. Immunotherapy 2: 1-3, 2010
391. Banks, W.A. Gut-brain communications: Not the same at all ages. (News and Views).
Endocrinology 151: 852-4, 2010.
392. Price, T.O., S.A. Farr, X. Yi, S. Vinogradov, E.V. Batrakova, W.A. Banks, A.V.
64
Kabanov. Transport across the blood-brain barrier of pluronic leptin. J. Pharmacol. Exp.
Therap. 333: 253-63, 2010. PMFID 20053933
393. Banerjee, A., X. Zhang, K. Reddy, W.A. Banks, N. Ercal. HIV proteins (gp120 and Tat)
and methamphetamine in oxidative stress-induced damage in the brain: Potential role of
the thiol antioxidant N-acetyl cysteine amide. Free Radic. Biol. Med. 48: 1388-98, 2010.
394. Peter, JC, AC Lecourt, M Weckering, G. ZipFfel, ML Niehoff, WA Banks, KG
Hofbauer. A pharmacologically active monoclonal antibody against the human
melanocortin-4 receptor: effectiveness after peripheral and central administration. J.
Pharmacol. Exp. Therap. 333: 478-90, 2010. PMID 20118207
395. Morley, J.E., S.A. Farr, W.A. Banks, S.N. Johnson, K.A. Yamada, L. Xu. A
physiological role for amyloid-beta protein: Enhancement of learning and memory. J.
Alzheimer’s Disease. 19: 441-449, 2010. PMID: 19749407
396. Ducharme, N., W.A. Banks, J.E. Morley, S.M. Robinson, M.L. Niehoff, C. Mattern, S.A.
Farr. Brain distribution and behavioral effects of progesterone and pregnenolone after
intranasal or intravenous administration. Eur. J. Pharmacol. 641: 128-134, 2010.
397. Morley, J.E. and W.A. Banks. Lipids and cognition. J. Alzheimer’s Disease. 20: 737-
747, 2010.
398. Threlkeld, S.W., J.L. Lynch, K.M. Lynch, G. Sadowska, W.A. Banks, B.S. Stonestreet.
Ovine pro-inflammatory cytokines cross the murine blood-brain barrier by a common
saturable transport mechanism. Neuroimmunomodulation 17: 405-410, 2010.
399. Haren, M.T., T.K. Malmstrom, D.K. Miller, P. Patrick, H.M. Perry 3rd, M.M. Herning,
W.A. Banks, J.E. Morley. Higher C-reactive protein and soluble tumor necrosis factor
receptor levels are associated with poor physical function and disability: A crosssectional
analysis of a cohort of late middle-aged African Americans. J. Gerontology A:
Medical Sciences 65: 274-81, 2010. PMID: 19812256 PMC 2822280
400. Cheng, F., P.J. McLaughlin, W.A. Banks, I.S. Zagon. Internalization of the opioid
growth factor [Met5]-enkephalin, is dependent on clathrin-mediated endocytosis for
downregulation of cell proliferation. Am. J. Physiol.: Reg. Integr. Comp. Physiol. 299:
R774-85, 2010.
401. Banks, W.A. Mouse models of neurological disorders: A view from the blood-brain
barrier. Biochimica et Biophysica Acta 1802: 881-888, 2010.
402. Banks, W.A., J.E. Morley, J.L. Lynch, K.M. Lynch, A.D. Mooradian. Insulin detemir is
not transported across the blood-brain barrier. Peptides 31:2284-8, 2010.
65
403. Banks, W.A., J.E. Morley, S.A. Farr, T.O. Price, N. Ercal, I. Vidaurre, A.V. Schally.
Effects of a growth hormone-releasing hormone antagonist on telomerase activity,
oxidative stress, longevity, and aging in mice. Proc. Natl. Acad. Sci. USA 107: 22272-
22277, 2010.
404. Owens, J.B., R. Sultana, C.D. Aluise, M.A. Erickson, T.O. Price, G. Bu, W.A. Banks,
D.A. Butterfield. Oxidative modification to LDL-related protein 1 (LRP1) in
hippocampus from subjects with Alzheimer’s disease: Implications of A? accumulation
in AD brain. Free Radic. Biol. Med. 49:1798-803, 2010.
405. Banks, W.A., V.B. Kumar, S.A. Farr, R. Nakaoke, S.M. Robinson, J.E. Morley.
Impairments in brain-to-blood transport of amyloid-beta and reabsorption of
cerebrospinal fluid in an animal model of Alzheimer’s disease are reversed by antisense
directed against amyloid-beta protein precursor. J. Alzheimer’s Disease 23: 599-605,
2011.
406. Haren, M.T., A.M. Siddiqui, H.J. Armbrecht, R.T. Kevorkian, M.J. Kim, M.J. Haas, A.
Mazza, V.B. Kumar, M. Green, W.A. Banks, and J.E. Morley. Testosterone modulates
gene expression pathways regulating nutrient accumulation, glucose metabolism, and
protein turnover in mouse skeletal muscle. Int. J. Androl 34: 55-68, 2011.
407. Morley, J.E., S.A. Farr, R.L. Sell, S.M. Hileman, and W.A. Banks Nitric oxide is a
central component in neuropeptide regulation of appetite. Peptides 32: 776-780, 2011.
408. Sandoval, K.E., S.A. Farr, W.A. Banks, M.L. Niehoff, A.M. Crider, and K.A. Witt.
Chronic peripheral administration of somatostatin receptor subtype-4 agonist NNC 26-
9100 enhances learning and memory in SAMP8 mice. Eur. J. Pharmacol 654: 53-59,
2011.
409. Manda, K.R., A. Banerjee, W.A. Banks, and N. Ercal. Highly active antiretroviral
Therapy drug combination induces oxidative stress and mitochondrial dysfunction in
Immortalized human blood-brain barrier endothelial cells. Free Radic. Biol. Med. 50:
801-810, 2011.
410. Urayama A., R. Morales, M.L. Niehoff, W.A. Banks, and C. Soto. Initial fate of prions
upon peripheral infection: half-life, distribution, clearance, and tissue uptake. FASEB J.
25:2792-2803, 2011.
411. Banks, W.A. Extra-hypothalamic effects of leptin: A therapeutic for depression and
dementia? Endocrinology (News and Views) 152: 2539-2541, 2011.
412. Nicolazzo, J.A. and W.A. Banks. Editorial: Decreased blood-brain barrier expression of P
glycoprotein in Alzheimer’s disease: impact on pathogenesis and brain access of
therapeutic agents. Therapeutic Delivery 2: 841-844, 2011.
66
413. Banks, W.A. Measurement of phosphorothioate oligodeoxynucleotide antisense transport
across the blood-brain barrier. Methods in Molecular Biology, Neuropeptides: Methods
and Protocols. 789:337-42, 2011.
414. Erickson, M.A. and W.A. Banks. Cytokine and chemokine responses in serum and brain
after single and repeated injections of lipopolysaccharide: Multiplex quantification with
path analysis. Brain, Behavior, & Immunity 25: 1637-48, 2011.
415. Banks, W.A., A. Gertler, G. Solomon, L. Niv-Spector, M. Yacobovitz, X. Yi, E.
Batrakova, S. Vinogradov, and A.V. Kabanov. Principles of strategic drug delivery to
the brain (SDDB): Development of anorectic and orexigenic analogs of leptin. Physiol.
Behav. 105: 145-9, 2011.
416. Kovac, A., M.A. Erickson, and W.A. Banks. Brain microvascular pericytes are
immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in
response to lipopolysaccharide. J. Neuroinflammation 8: 139, 2011.
417. Dohgu, S., M.A. Fleegal-DeMotta, and W.A. Banks. Lipopolysaccharide-enhanced
transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal
microvessel IL-6 and GM-CSF. J. Neuroinflammation 8: 167, 2011.
418. Chen, X., S.W. Threlkeld, E.E. Cummings, I. Juan, O. Makeyev, W.G. Besio, J. Gaitanis,
W.A. Banks, G.B. Sadowska, and B.S. Stonestreet. Ischemia-reperfusion impairs blood
brain barrier function and alters tight junction protein expression in the ovine fetus.
Neuroscience 226: 89-110, 2012.
419. Price, T.O., V. Eranki, W.A. Banks, N. Ercal, and G.N. Shah. Topiramate treatment
protects blood-brain barrier pericytes from hyperglycemia-induced oxidative damage in
diabetic mice. Endocrinology 153: 362-72, 2012.
420. Erickson, M.A., K. Dohi, and Banks, W.A. Neuroinflammation: A common pathway in
CNS diseases as mediated at the blood-brain barrier. NeuroImmunoModulation 19:
121-130, 2012.
421. Banks, W.A. The blood-brain barrier: Structure and function. In: The Neurology of
AIDS 3rd Edition. H.E. Gendelman, (eds). Oxford University Press, Oxford, p189-206,
2012.
422. Farr, S.A., T.O. Price, L.J. Dominguez, A. Motisi, F. Saiano, M.L. Niehoff, J.E. Morley,
W.A. Banks, N. Ercal, and M. Barbagallo. Extra virgin olive oil improves learning and
memory in SAMP8 mice. J. Alzheimer’s Disease 28: 81-92, 2012.
423. Erickson, M.A. and W.A. Banks. Peripheral administration of antisense oligonucleotides
67
targeting the amyloid-beta protein precursor reverses ABetaPP and LRP-1
overexpression in the aged SAMP8 mouse brain. J. Alzheimer’s Disease 28: 951-960,
2012.
424. Banks, W.A. Drug delivery to the brain in Alzheimer’s disease: Considerations of the
blood-brain barrier. Advances in Drug Delivery Reviews 64: 629-639, 2012.
425. Sandoval, K.E., S.A. Farr, W.A. Banks, A.M. Crider, J.E. Morley, and K.A.Witt.
Somatostatin receptor subtype-4 agonist NNC 26-9100 decreases extracellular and
intracellular Abeta1-42 trimers. European J Pharmacol. 683:116-124, 2012.
426. Mayo, J.N., R.S. Beard Jr, T.O. Price, C.-H. Chen, M.A. Erickson, N. Ercal, W.A. Banks,
and S.E. Bearden. Nitrative stress in cerebral endothelium is mediated by mGluR5 in
hyperhomocysteinemia. J. Cereb. Blood Flow and Metab. 32: 825-834, 2012.
427. Banks, W.A. Drug transport into the central nervous system: Using newer findings about
the blood-brain barriers. Drug Delivery and Translational Research 2:152-159, 2012.
428. Dohgu, S., J.S. Ryerse, S.M. Robinson, and W.A. Banks. Human immunodeficiency
virus-1 uses the mannose-6-phosphate receptor to cross the blood-brain barrier. PLoS
One 7: e39565, 2012.
429. Nonaka, N., S.A. Farr, T. Nakamachi, J.E. Morley, M. Nakamura, S. Shioda, and W.A.
Banks. Intranasal administration of PACAP: Uptake by brain and regional brain
targeting with cyclodextrins. Peptides 36: 168-175, 2012.
430. Patel, A., Y. Zhu, E.V. Kuzhikandathil, W.A. Banks, A. Siegel, and S.S. Zalcman.
Soluble interleukin-6 receptor induces motor stereotypies and co-localizes with Gp130 in
regions linked to cortico-striato-thalamo-cortical circuits. Plos One 7: e41623, 2012.
431. Erickson, M.A., P.E. Hartvigson, Y. Morofuji, J.B. Owen, D.A. Butterfield, and W.A.
Banks. Lipopolysaccharide impairs amyloid beta efflux from brain: altered vascular
sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transport
function at the blood-brain barrier. J. Neuroinflammation 9: 150, 2012.
432. Banks, W.A. Role of the Blood-brain Barrier in the Evolution of Feeding and Cognition.
New York Academy of Sciences, 1264:13-19, 2012.
433. Banks, W.A., J.B. Owen, and M.A. Erickson. Insulin in the brain: There and back again.
Pharmacology and Therapeutics 136: 82-93, 2012.
434. Banks, W.A. Brain meets body: The blood-brain barrier as an endocrine interface.
Endocrinology 153: 4111-4119, 2012.
68
435. Erickson, M.A., K. Hansen, and W.A. Banks. Inflammation-induced dysfunction of the
low density lipoprotein receptor-related protein-1 at the blood-brain barrier: Protection by
the antioxidant N-acetylcysteine. Brain, Behavior, & Immunity 26: 1085-1094, 2012.
436. Banks, W.A., M.L. Niehoff, N.M. Ponzio, M.A. Erickson, and S. S. Zalcman.
Pharmacokinetic and modeling of immune cell trafficking: quantifying differential
influences of target tissues versus lymphocytes in SJL and Lipopolysaccharide-treated
mice. J. Neuroinflammation 9: 231, 2012.
437. Farr, S.A., T.O. Price, W.A. Banks, N. Ercal, and J.E. Morley. Effect of alpha-lipoic acid
on memory, oxidation, and lifespan in SAMP8 mice. J. of Alzheimer’s Disease, 32: 447-
455, 2012.
438. Harati, R., A.S. Villegier, W.A. Banks, and A. Mabondzo. Susceptibility of juvenile and
adult blood-brain barrier to endothelin-1: regulation of P-glycoprotein and breast cancer
resistance protein expression and transport activity. J. Neuroinflammation 9:273, 2012.
439. Vasselli, J.R., P.J. Scarpace, R.B. Harris, and W.A. Banks. Dietary components in the
development of leptin resistance. Adv. Nutr. 4: 164-175, 2013.
440. Tong, J., X. Yi, R. Luxenhofer, W.A. Banks, R. Jordan, M.C. Zimmerman, and A.V.
Kabanov. Conjugates of super oxide dismutase 1 with amphiphilic poly(2-oxazoline)
block copolymers for enhanced brain delivery: synthesis, characterization and evaluation
in vitro and in vivo. Mol. Pharm. 10: 360-377, 2013.
441. Peter, J.C., H. Rossez, M. Weckering, G. Zipfel, A.C. Lecourt, J.B. Owen, W.A. Banks,
and K.G. Hofbauer. Protective effects of an anti-melanocortin-4 receptor scFv derivative
in lipopolysaccharide-induced cachexia in rats. J. Cachexia Sarcopenia Muscle 4: 79-88,
2013.
442. Banks, W.A. Chapter 227. Diseases mediated by the BBB: Alzheimer’s, obesity, and
beyond. In Handbook of Biologically Active Peptides 2nd Edition. A.J. Kastin (ed).
Academic Press, Elsevier, Amsterdam, p1667-1671, 2013.
443. Banks, W.A., Ch 229. Ingestive Peptides. In Handbook of Biologically Active Peptides
2nd Edition. A.J. Kastin (ed). Academic Press, Elsevier, Amsterdam, p1677-1681, 2013.
444. Tobwala, S., X. Zhang, Y. Zheng, H.-J. Wang, W.A. Banks, and N. Ercal. Disruption of
the integrity and function of brain microvascular endothelial cells in culture by exposure
to diesel engine exhaust particles. Toxicology Letters 220: 1-7, 2013.
445. Shah, G.N., T.O. Price, W.A. Banks, Y. Morofuji, A. Kovac, N. Ercal, C.M. Sorenson,
E.S. Shin, N. Sheibani. Pharmacological inhibition of mitochondrial carbonic anhydrases
protects mouse cerebral pericytes from high glucose-induced oxidative stress and
69
apoptosis. J. Pharmacol. Exp. Therap. 344: 637-645, 2013.
446. Rhodehouse, B.C., M.A. Erickson, W.A. Banks, S.E. Bearden. Hyperhomocysteinemic
mice show cognitive impairment without features of Alzheimer’s disease phenotype. J.
Alzheimer’s Disease 35: 59-66, 2013.
447. Sandoval, K.E., S.A. Farr, W.A. Banks, A.M. Crider, J.E. Morley, K.A. Witt.
Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble
Abeta42 oligomers via a metalloproteinase-dependent mechanism. Brain Res. 1520: 145
156, 2013.
448. Banks, W.A. Artificial emotions: robots caring for the elderly. J. Am. Dir. Assoc. 14:
635-6, 2013.
449. Dohgu, S. and W.A. Banks. Brain pericytes increase the lipopolysaccharide-enhanced
transcytosis of HIV-1 free virus across the in vitro blood-brain barrier: evidence for
cytokine-mediated pericyte-endothelial cell crosstalk. Fluids Barriers CNS 10: 23, 2013.
450. Erickson, M.A. and W.A. Banks. Blood-brain barrier dysfunction as a cause and
consequence of Alzheimer’s disease. J. Cereb. Blood Flow Metab. 33:1500-13, 2013.
451. Shah, G.N., Y. Morofuji, W.A. Banks, T.O. Price. High glucose-induced mitochondrial
resistance and reactive oxygen species in mouse cerebral pericytes is reversed by
pharmacological inhibition of mitochondrial carbonic anhydrase: implications for
cerebral microvascular diseases in diabetes. Biochem. Biophys. Res. Comm. 440: 354-
358, 2013.
452. Hayden, M.R., W.A. Banks, G.N. Shah, Z. Gu, J.R. Sowers. Cardiorenal metabolic
syndrome and diabetic cognopathy. Cardiorenal Med 3: 265-282, 2013.
453. Armbrecht, H.J., A.M. Siddiqui, M. Green, S.A. Farr, V.B. Kumar, W.A. Banks, P.
Patrick, G.N. Shah, and J.E. Morley. SAMP8 mice have altered hippocampal gene
expression in long term potentiation, phosphotidylinositol signaling, and endocytosis
pathways. Neurobiol. Aging 35: 159-68, 2014.
454. Yi, X., D. Yuan, S.A. Farr, W.A. Banks, C.-D. Poon, and A.V. Kabanov. Pluronic
modified leptin with increased systemic circulation, brain uptake and efficacy for
treatment of obesity. J Control. Release 191: 34-46, 2014.
455. Calias, P., W.A. Banks, D. Begley, M. Scarpa, P. Dickson. Intrathecal delivery of protein
therapeutics to the brain: A critical reassessment. Pharmacol. Ther. 144:114-122, 2014.
456. Banks, W.A. Control and contribution of the blood-brain barrier to cytokine levels in the
CNS. In: The Wiley-Blackwell Handbook of Psychoneuroimmunology, A.W. Kusnecov
70
and H. Anisman (eds.), Wiley-Blackwell, 88-98, 2014.
457. Dohi, K., B.C. Kraemer, M.A. Erickson, P.J. McMillan, A. Kovac, Z. Flachbartova, K.M.
Hansen, G.N. Shah, N. Sheibani, T. Salameh, W.A. Banks. Molecular hydrogen in
drinking water protects against neurodegenerative changes induced by traumatic brain
injury. PLOS One 9: e108034, 2014.
458. Salameh, T.S. and W.A. Banks. Delivery of therapeutic peptides and proteins to the
CNS. In: Pharmacology of the Blood Brain Barrier: Targeting CNS Disorders. Editor:
T.P. Davis. Elsevier, Amsterdam, pp277-299, 2014.
459. Tobwala, S. H.-J. Wang, J.W. Carey, W.A. Banks, N. Ercal. Effects of lead and
cadmium on brain endothelial cell survival, monolayer permeability, and crucial
oxidative stress markers in an in vitro model of the blood-brain barrier. Toxics 2: 258-
275, 2014.
460. Farr, S.A., M.A. Erickson, M.L. Niehoff, W.A. Banks, J.E. Morley. Central and
peripheral administration of antisense oligonucleotide targeting amyloid precursor protein
improves learning and memory and reduces neuroinflammatory cytokines in T62576
(APPswe) Mice. J Alzheimer’s Disease. 40: 1005-1016, 2014.
461. Erickson, M.A., Y Morofuji, J.B. Owen, W.A. Banks. Rapid transport of CCL11 across
the blood-brain barrier: regional variation and importance of blood cells. J. Pharmacol.
Exp. Therap. 349: 497-507, 2014.
462. Falcone, J.A., T.S. Salameh, X. Yi, B.J. Cordy, W.G. Mortell, A.V. Kabanov, W.A.
Banks. Intranasal administration as a route for drug delivery to the brain: Evidence for a
unique pathway for albumin. J. Pharmacol. Exp. Therap. 351: 54-60, 2014.
463. Shi, M. C.. Liu, T.J. Cook, K.M. Bullock, Y. Zhao, C. Ginghina, Y. Li, P. Aro, R. Dator,
C. He, M.J. Hipp, C.P. Zabetian, E.R. Peskind, S.C. Hu, J.F. Quinn, D.R. Galasko, W.A.
Banks, J. Zhang. Plasma exosomal alpha-synuclein is likely CNS-derived and increased
in Parkinson’s disease. Acta Neuropathol.128: 639-650, 2014.
464. Sui, Y.-T., K.M. Bullock, M.A. Erickson, J. Zhang, W.A. Banks. Alpha synuclein is
transported into and out of the brain by the blood-brain barrier. Peptides 62:197-202,
2014.
465. Banks, W.A., C.K. Abrass, K.M. Hansen. Differentiating influences of aging and
adiposity on brain weights, levels of serum and brain cytokines, gastrointestinal
hormones, and amyloid precursor peptide. J. Gerontol. A Biol. Sci. Med. Sci. epub 2014;
71:21-29, 2016.
466. Banks, W.A. The blood-brain barrier in neuroimmunology: Tales of separation and
71
assimilation. Brain, Behavior, & Immunity 44:1-8, 2015.
467. Chen, X., G.B. Sadowska, J. Zhang, J.-E. Kim, E.E. Cummings, C.A. Bodge, Y.-P. Lim,
O. Makeyev, W.G. Besio, J. Gaitanis, S.W. Threlkeld, W.A. Banks, B.S. Stonestreet.
Neutralizing anti-interleukin-1 beta antibodies modulate fetal blood-brain barrier function
after ischemia. Neurobiology of Disease 73: 118-129, 2015.
468. Hanson, A.J., S. Craft, W.A. Banks. The APOE genotype: Modification of therapeutic
responses in Alzheimer’s disease. Current Pharmaceutical Design 21: 114-120, 2015.
469. Hong, S. and W.A. Banks. Role of the immune systemin HIV-associated neurocognitive
impairment and neuroinflammation. Brain, Behavior, & Immunity 45:1-12, 2015.
470. Zhang, J., G.B. Sadowska, X. Chen, S.Y. Park, J.E. Kim, C.A. Bodge, E. Cummings,
Y.P. Lim, O. Makeyev, W.G. Besio, J. Gaitanis, W.A. Banks, B.S. Stonestreet. Anti-IL
6 neutralizing antibody modulates blood-brain barrier function in the ovine fetus.
FASEB J 29: 1739-53, 2015.
471. Meredith, M.E. T.S. Salameh, W.A. Banks. Intranasal delivery of proteins and peptides
in the treatment of neurodegenerative diseases. AAPS J. 17: 780-7, 2015.
472. Sadowska, G., X. Chen, J. Zhang, E. Cummings, O. Makeyev, W. Besio, J. Gaitanis, J.
Padbury, W.A. Banks, B. Stonestreet. Interleukin-1 beta transfer across the blood-brain
barrier in the ovine fetus. J Cereb Blood Flow Metab 35: 1388-95, 2015.
473. Banks, W.A. A vagina monologue: Mom’s stress, bugs, and baby’s brain. Endocrinology
156: 3066-8, 2015.
474. Armbrecht, H.J., A.M. Siddiqui, M. Green, S.A. Farr, V.B. Kumar, W.A. Banks, P.
Patrick, G. N. Shah, and J.E. Morley. Antisense against amyloid-beta protein precursor
reverses memory deficits and alters gene expression in neurotropic and insulin-signaling
pathways in SAMP8 mice. J Alzheimer’s Disease 46: 535-548, 2015.
475. Salameh, T.S., K.M. Bullock, I.A. Hujoel, M.L. Niehoff, T. Wolden-Hanson, J. Kim, J.E.
Morley, S.A. Farr, W.A. Banks. Central nervous system delivery of intranasal insulin:
mechanisms of uptake and effects on cognition. J Alzheimer’s Disease 47: 715-728,
2015.
476. Patrick, P., T.O. Price, A.L. Diogo, N. Sheibani, W.A. Banks, G.N. Shah. Topiramate
protects pericytes from glucotoxicity: Role for mitochondrial CA VA in
cerebromicrovascular disease in diabetes. Journal Endocrinology and Diabetes 2: 1-7,
2015.
477. Thielke, S., C. G. Slatore, W.A. Banks. Association between Alzheimer dementia
72
mortality rate and altitude in California counties. JAMA Psychiatry 72: 1253-1254.
478. Opp, M.R., A. George, K.M. Ringgold, K.M. Hansen, Kristin M. Bullock, W.A. Banks.
Sleep fragmentation and sepsis differentially impact blood-brain barrier integrity and
transport of tumor necrosis factor-alpha in aging. Brain, Behavior, & Immunity 50: 259-
265, 2015.
479. Urayama, A., S. Dohgu, S.M. Robinson, W.S. Sly, J.H. Grubb, and W.A. Banks. Alpha
adrenergic induction of transport of lysosomal enzyme across the blood-brain barrier.
PLoS One 10: e0142347, 2015.
480. Banks, W.A., A.M. Gray, M.E. Erickson, T.S. Salameh, M. Damodarasamy, N. Sheibani,
J.S. Meabon, E.E. Wing, Y. Morofuji, D.G. Cook, and M.J. Reed. Lipopolysaccharideinduced
blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress,
neuroinflammation, and elements of the neurovascular unit. J. Neuroinflammation 12:
223, 2015.
481. Banks, W.A. Peptides and the blood-brain barrier. Peptides 72: 16-19, 2015.
482. Banks, W.A., K. Dohi, K. Hansen, and H.J. Thompson. Assessing blood granulocyte
colony-stimulating factor as a potential biomarker of acute traumatic brain injury in mice
and humans. Brain, Behavior, & Immunity 52: 81-87, 2016.
483. Wong, S.Y., M.G.K. Tan, W.A. Banks, W.S.F. Wong, P.T.-H. Wong, and M.K.P. Lau.
Andrographolide attenuates LPS-stimulated up-regulation of C-C and C-X-C motif
chemokines in rodent cortex and primary astrocytes. J. Neuroinflamm. 13, 34, 2016.
484. Brown, R.S.E., A.K. Wyatt, R.E. Herbison, P.J. Knowles, S.R. Ladyman, N. Binart,
W.A. Banks, D.R. Grattan. Prolactin transport into the bain of mice is independent of the
prolactin receptor. FASEB 30:1002-1010, 2016.
485. Huber, B.R., J.S. Meabon, Z.S. Hoffer, J. Zhang, J.G. Hoekstra, K.F. Pagulayan, P.J.
McMillan, W.A. Banks, B.C. Kraemer, M.A. Raskind, D.B. McGavern, E.R. Peskind,
D.G. Cook. Blast exposure causes dynamic microglial/macrophage responses and
microdomains of brain microvessel dysfunction. Neuroscience 19:206-220, 2016.
486. Banks, W.A. From blood-brain barrier to blood-brain interface: New opportunities for
CNS drug delivery. Nature Reviews Drug Discovery (invited review) 15: 275-292, 2016.
487. Urayama, A., J.H. Grubb, W.S. Sly, and W.A. Banks. Pharmacologic manipulation of
lysosomal enzyme transport across the blood-brain barrier. J Cereb Blood Flow Metab
36:476-486, 2016.
488. Hanson, A.J., W.A. Banks, H.H. Saucedo, and S. Craft. Apolipoprotein E genotype and
73
sex influence glucose tolerance in older adults: A cross sectional study. Dementia and
Geriatric Cognitive Disorders 6:78-89, 2016.
In Press
Del Razo, M.J., Y. Morofuji, J.S. Meabon, B.R. Huber, E.R. Peskind, S.A. Banks, P. Mourad,
R.J. Leveque, D.G. Cook. Computational and in vitro studies of blast-induced blood-brain
barrier disruption. Society for Industrial and Applied Mathematics: Journal on Scientific
Computing.
Shi, M., A. Kovac, A. Korff, D.J. Cook, C. Ginghina, K.M. Bullock, L. Yang, D. Zheng, P. Aro,
T. Stewart, D. Zheng, A. Atik, K.F. Kerr, C.P. Zabetian, E.R. Peskind, S.-C. Hu, J.F. Quinn,
D.R. Galasko, T.J. Montine, W.A. Banks, and J. Zhang. CNS tau efflux via exosomes is likely
increased in Parkinson disease but not Alzheimer disease. Alzheimer’s & Dementia
Matoba, Y., N. Nonaka, Y. Takagi, E. Imamura, M. Narukawa, T. Nakamachi, S. Shoida, W.A.
Banks, M. Nakamura. Pituitary adenylate cyclase-activating polypeptide enhances saliva
secretion via direct binding to PACAP receptors of major salivary glands in mice. Anat Rec
(Hoboken).
Submitted
Banks, W.A. Transport of pituitary adenylate cyclase activating polypeptide across the bloodbrain
barrier: Consequences for disease states and therapeutic effects
Patra, A., X. Chen, G.B. Sadowska, J. Zhang, Y.-P. Lim, J.F. Padbury, W.A. Banks, B.S.
Stonestreet. Cytokine neutralizing antibodies reduce ischemia-related cytokine transport across
the fetal blood-brain barrier.
Yuan, D. Y. Zhao, W.A. Banks, M. Haney, E. Batrakova, A.V. Kabanov. Macrophage
exosomes as natural nanocarriers for neurotrophin delivery to inflamed brain.
Green, S., A. Kaipainen, K. Bullock, A. Zhang, J. Lucas, C. Matson, W.A. Banks, E.A.
Mostaghel. Role of OATP transporters in steroid uptake by prostate cancer cells in vivo.
Werling, D., D. Reglodi, W.A. Banks, T.S. Salameh, K. Kovacs, T. Kvarik, A. Vaczy, L.
Kovacs, F. Mayer, B. Danyadi, E. Lokos, A. Tamas, G. Toth, Z. Biro, T. Atlasz. A novel route of
retinoprotective action of PACAP in ischemic retinopathy.
74
Jiang, Y., J. Fay, X. Yi, C.-D. Poon, Y. Zhao, K. Bullock, D. Manickam, W.A. Banks, A.V.
Kabanov. Block ionomer complex nanoformulation stablizes brain derived neurotorphic factor
and increases its delivery to the brain after intranasal administration.
Mostaghel, E., A. Kaipainen, S. Green, A. Zhang, J. Lucas, C. Mattson, K. Bullock, W. Banks.
Role of OATP transporters in steroid uptake by prostate cancer cells in vivo. Prostate Cancer and
Prostatic Diseases