Dr. Jiangang Long, PhD. (Xi’an Jiaotong University)



Mitochondrion is the key organelle for cellular ATP supply and apoptosis signaling. We are engaged in exploring mitochondrial metabolism under physiological and pathological conditions, and pursuing the mitochondrion-targeted molecules to improve mitochondrial function and maintain mitochondrial homeostasis damaged during neurodegeneration and nutritional imbalance.
Since the discovery of the antioxidant effect of H2 in 2007, we recently identified the beneficial effects of H2 on mitochondrial respiratory capacity and phase 2 enzymes activation. Therefore, we considered that H2 acts as a “mitochondrial nutrient”, which will be very promising molecule in preventing and treating age-related disease and metabolic syndromes.

Professor and Vice Dean of School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, China

Specialized field
Mitochondrial Degeneration & Therapeutic Intervention in Aging, Neurodegenerative Diseases and Metabolic Syndromes

Career Summary
2011- Professor, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, China
2009-2011 Associate Professor, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, China
2008-2009 Postdoctoral fellow, Banner (Sun) Health Research Institute, AZ, USA
2006-2008 Postdoctoral fellow, Institute for Brain Aging and Dementia, University of California,
Irvine , CA, and Children’s Hospital Oakland Research Institute, CA, USA

Research publication
1. Hu R, Diao J, Li J, Tang Z, Li X, Leitz J, Long J, Liu J, Yu D, Zhao Q. (2016) Intrinsic and membrane-facilitated ?-synuclein oligomerization revealed by label-free detection through solid-state nanopores. Sci Rep. [Epub ahead of print] IF 5.578
2. Wang P, Jia L, Chen B, Zhang L, Liu J, Long J*, Li Y. (2016) Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats. Shock. [Epub ahead of print] IF 3.045
3. Huang H, Yang L, Zhang P, Qiu K, Huang J, Chen Y, Diao J, Liu J, Ji L, Long J*, Chao H*. (2016) Real-time tracking mitochondrial dynamic remodeling with two-photon phosphorescent iridium (III) complexes. Biomaterials. IF 8.557
4. Hou C, Wang Y, Zhu E, Yan C, Zhao L, Wang X, Qiu Y, Shen H, Sun X, Feng Z, Liu J*, Long J*.(2016) Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer.Biochem Pharmacol. IF 5.009
5. Liu J, Peng Y, Wang X, Fan Y, Qin C, Shi L, Tang Y, Cao K, Li H, Long J*, Liu J*. (2016) Mitochondrial Dysfunction Launches Dexamethasone-Induced Skeletal Muscle Atrophy via AMPK/FOXO3 Signaling. Mol Pharm. 13(1):73-84. IF 4.384
6. Tang Y, Peng Y, Liu J, Shi L, Wang Y, Long J*, Liu J*. (2015) Early inflammation-associated factors blunt sterol regulatory element-binding proteins-1-mediated lipogenesis in high-fat diet-fed APPSWE /PSEN1dE9 mouse model of Alzheimer’s disease. J Neurochem. [Epub ahead of print] IF 4.281
7. Tang Y, Liu J, Long J*. (2015) Phosphatase and tensin homolog-induced putative kinase 1 and Parkin in diabetic heart: Role of mitophagy. J Diabetes Investig 3, 250-5. IF 1.8
8. Zheng A, Li H, Xu J, Cao K, Li H, Pu W, Yang Z, Peng Y, Long J, Liu J, Feng Z.(2015)Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation. Br J Nutr, 111667-76. IF 3.453
9. Sun L, Liu T, Li H, Yang L, Meng L, Lu Q, Long J.(2015) Fluorescent and cross-linked organic-inorganic hybrid nanoshells for monitoring drug delivery. ACS Appl Mater Interfaces 8, 4990-7.IF 6.723
10. Luo C, Li Y, Yang L, Zheng Y, Long J, Jia J, Xiao S, Liu J. (2014) Activation of Erk and p53 regulates copper oxide nanoparticle-induced cytotoxicity in keratinocytes and fibroblasts.Int J Nanomedicine 9,4763-72. IF 4.383
11. Zou, X., Yan, C., Shi, Y., Cao, K., Xu, J., Wang, X., Chen, C., Luo, C., Li, Y., Gao, J., Pang, W., Zhao, J., Zhao, F., Li, H., Zheng, A., Sun, W., Long, J., Szeto, I. M., Zhao, Y., Dong, Z., Zhang, P., Wang, J., Lu, W., Zhang, Y., Liu, J., and Feng, Z. (2014) Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: the protective effects of pomegranate with its active component punicalagin. Antioxid Redox Signal 21, 1557-1570. IF 7.67
12. Zhao, L., Zou, X., Feng, Z., Luo, C., Liu, J., Li, H., Chang, L., Wang, H., Li, Y., Long, J*., and Gao, F. (2014) Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats. Exp Gerontol 56, 3-12.IF 3.53
13. Tang, Y., Mi, C., Liu, J., Gao, F., and Long, J*. (2014) Compromised mitochondrial remodeling in compensatory hypertrophied myocardium of spontaneously hypertensive rat. Cardiovasc Pathol 23, 101-106. IF 2.4
14. Peng, Y., Liu, J., Tang, Y., Han, T., Han, S., Li, H., Hou, C., and Long, J*. (2014) High-Fat-Diet-Induced Weight Gain Ameliorates Bone Loss without Exacerbating AbetaPP Processing and Cognition in Female APP/PS1 Mice. Front Cell Neurosci 8, 225. IF 4.18
15. Luo, C., Li, Y., Zhou, B., Yang, L., Li, H., Feng, Z., Long, J., and Liu, J. (2014) A monocarbonyl analogue of curcumin, 1,5-bis(3-hydroxyphenyl)-1,4-pentadiene-3-one (Ca 37), exhibits potent growth suppressive activity and enhances the inhibitory effect of curcumin on human prostate cancer cells.Apoptosis 19, 542-553. IF 3.61
16. Luo, C., Li, Y., Yang, L., Zheng, Y., Long, J., Jia, J., Xiao, S., and Liu, J. (2014) Activation of Erk and p53 regulates copper oxide nanoparticle-induced cytotoxicity in keratinocytes and fibroblasts. Int J Nanomedicine 9, 4763-4772. IF 4.20
17. Luo, C., Li, Y., Yang, L., Wang, X., Long, J., and Liu, J. (2014) Superparamagnetic iron oxide nanoparticles exacerbate the risks of reactive oxygen species-mediated external stresses. Arch Toxicol . IF 5.1
18. Liu, Y., Long, J., and Liu, J. (2014) Mitochondrial free radical theory of aging: who moved my premise? Geriatr Gerontol Int 14, 740-749. IF 1.58
19. Liu, J., Tang, Y., Feng, Z., and Long, J*. (2014) (-)-Epigallocatechin-3-gallate attenuated myocardial mitochondrial dysfunction and autophagy in diabetic Goto-Kakizaki (GK) rats. Free Radic Res 48, 898-906. IF 3.00
20. Liu, J., Tang, Y., Feng, Z., Hou, C., Wang, H., Yan, J., Shen, W., Zang, W., and Long, J*. (2014) Acetylated FoxO1 mediates high-glucose induced autophagy in H9c2 cardiomyoblasts: regulation by a polyphenol -(-)-epigallocatechin-3-gallate. Metabolism 63, 1314-1323. IF 3.61
21. Liu, J., Peng, Y., Feng, Z., Shi, W., Qu, L., Li, Y., and Long, J*. (2014) Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients. Free Radic Biol Med69, 116-128. IF 5.71
22. Chen, C., Han, X., Zou, X., Li, Y., Yang, L., Cao, K., Xu, J., Long, J., Liu, J., and Feng, Z. (2014) 4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (C75), an inhibitor of fatty-acid synthase, suppresses the mitochondrial fatty acid synthesis pathway and impairs mitochondrial function. J Biol Chem 289, 17184-17194. IF 4.6
23. Chang, L., Liu, X., Liu, J., Li, H., Yang, Y., Guo, Z., Xiao, K., Zhang, C., Zhao-Wilson, X., andLong, J*. (2014) D-galactose induces a mitochondrial complex I deficiency in mouse skeletal muscle: potential benefits of nutrient combination in ameliorating muscle impairment. J Med Food17, 357-364. IF 2.5
24. Cao, K., Zheng, A., Xu, J., Li, H., Liu, J., Peng, Y., Long, J., Zou, X., Li, Y., Chen, C., and Feng, Z. (2014) AMPK activation prevents prenatal stress-induced cognitive impairment: modulation of mitochondrial content and oxidative stress. Free Radic Biol Med 75, 156-166. IF 5.71
25. Cao, K., Xu, J., Zou, X., Li, Y., Chen, C., Zheng, A., Li, H., Szeto, I. M., Shi, Y., Long, J., Liu, J., and Feng, Z. (2014) Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radic Biol Med 67, 396-407. IF 5.71
26. Luo C, Wang H, Chen X, Cui Y, Li H, Long J, Mo X, Liu J (2013) Protection of H9c2 rat cardiomyoblasts against oxidative insults by total paeony glucosides from Radix Paeoniae Rubrae.Phytomedicine 21, 20-24.IF 3.3
27. Luo C, Li Y, Yang L, Feng Z, Long J, Liu J (2013) A cigarette component acrolein induces accelerated senescence in human diploid fibroblast IMR-90 cells. Biogerontology 14, 503-511. IF 3.2
28. Luo C, Li Y, Wang H, Feng Z, Long J*, Liu J (2013) Mitochondrial accumulation under oxidative stress is due to defects in autophagy. J Cell Biochem 114, 212-219. IF 3.4
29. Luo C, Li Y, Wang H, Cui Y, Feng Z, Li H, Wang Y, Wurtz K, Weber P, Long J*, Liu J (2013) Hydroxytyrosol promotes superoxide production and defects in autophagy leading to anti-proliferation and apoptosis on human prostate cancer cells. Curr Cancer Drug Targets 13, 625-639. IF 4.3
30. Cao K, Xu J, Zou X, Li Y, Chen C, Zheng A, Li H, Szeto IM, Shi Y, Long J, Liu J, Feng Z (2013) Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radic Biol Med 67C, 396-407. IF 5.3
31. Aksenov V, Long J, Liu J, Szechtman H, Khanna P, Matravadia S, Rollo CD (2013) A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice. Age (Dordr) 35, 23-33. IF 6.2
32. Yan J, Feng Z, Liu J, Shen W, Wang Y, Wertz K, Weber P, Long J*, Liu J (2012) Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto-Kakizaki (GK) rats: ameliorating effects of (-)-epigallocatechin-3-gallate. J Nutr Biochem 23, 716-724. IF 4.2
33. Long J, He P, Shen Y, Li R (2012) New evidence of mitochondria dysfunction in the female Alzheimer’s disease brain: deficiency of estrogen receptor-beta. J Alzheimers Dis 30, 545-558. IF 4.2
34. Long J, Gao M, Kong Y, Shen X, Du X, Son YO, Shi X, Liu J, Mo X (2012) Cardioprotective effect of total paeony glycosides against isoprenaline-induced myocardial ischemia in rats. Phytomedicine19, 672-676. IF 3.3
35. Long J, Aksenov V, Rollo CD, Liu J (2012) A complex dietary supplement modulates nitrative stress in normal mice and in a new mouse model of nitrative stress and cognitive aging. Mech Ageing Dev. IF 4.2
36. Liu J, Peng Y, Long J* (2012) The Role of Brain Mitochondrial Estrogen Receptor beta in The Pathogensis of Female Alzheimer’s Disease. Progress In Biochemistry And Biophysics, 785-790. IF 0.5
37. Liu J, Peng Y, Cui Z, Wu Z, Qian A, Shang P, Qu L, Li Y, Long J* (2012) Depressed mitochondrial biogenesis and dynamic remodeling in mouse tibialis anterior and gastrocnemius induced by 4-week hindlimb unloading. IUBMB Life. IF 3.8
38. Hao J, Shen W, Sun L, Long J, Sharman E, Shi X, Liu J (2011) Mitochondrial dysfunction in the liver of type 2 diabetic Goto-Kakizaki rats: improvement by a combination of nutrients. Br J Nutr106, 648-655. IF 3.2
39. Gao M, Li Y, Sun Y, Shah W, Yang S, Wang Y, Long J* (2011) Benzo[a]pyrene exposure increases toxic biomarkers and morphological disorders in mouse cervix. Basic Clin Pharmacol Toxicol 109, 398-406. IF 2.3
40. Gao M, Li Y, Sun Y, Long J, Kong Y, Yang S, Wang Y (2011) A common carcinogen benzo[a]pyrene causes p53 overexpression in mouse cervix via DNA damage. Mutat Res 724, 69-75. IF 3.2
41. Gao M, Li Y, Long J, Shah W, Fu L, Lai B, Wang Y (2011) Induction of oxidative stress and DNA damage in cervix in acute treatment with benzo[a]pyrene. Mutat Res 719, 52-59. IF 3.2
42. McAllister C, Long J, Bowers A, Walker A, Cao P, Honda S, Harada N, Staufenbiel M, Shen Y, Li R (2010) Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment.J Neurosci 30, 7326-7334.?co-first?IF 7.2
43. Gao M, Long J, Li Y, Shah W, Fu L, Liu J, Wang Y (2010) Mitochondrial decay is involved in BaP-induced cervical damage. Free Radic Biol Med 49, 1735-1745. IF 5.7
44. Aldarmaa J, Liu Z, Long J, Mo X, Ma J, Liu J (2010) Anti-convulsant effect and mechanism of Astragalus mongholicus extract in vitro and in vivo: protection against oxidative damage and mitochondrial dysfunction. Neurochem Res 35, 33-41.IF 2.7
45. Aksenov V, Long J, Lokuge S, Foster JA, Liu J, Rollo CD (2010) Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging. Exp Biol Med (Maywood) 235, 66-76.IF 2.7
46. Long J, Ma J, Luo C, Mo X, Sun L, Zang W, Liu J (2009) Comparison of two methods for assaying complex I activity in mitochondria isolated from rat liver, brain and heart. Life Sci 85, 276-280.IF 2.5
47. Long J, Liu C, Sun L, Gao H, Liu J (2009) Neuronal mitochondrial toxicity of malondialdehyde: inhibitory effects on respiratory function and enzyme activities in rat brain mitochondria. Neurochem Res 34, 786-794.IF 2.7
48. Long J, Gao H, Sun L, Liu J, Zhao-Wilson X (2009) Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson’s disease model. Rejuvenation Res 12, 321-331.IF 4.1
49. Long J, Gao F, Tong L, Cotman CW, Ames BN, Liu J (2009) Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res 34, 755-763.IF 2.7
50. Hao J, Shen W, Tian C, Liu Z, Ren J, Luo C, Long J, Sharman E, Liu J (2009) Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. J Cell Mol Med 13, 701-711. IF 4.6
51. Luo C, Long J, Liu J (2008) An improved spectrophotometric method for a more specific and accurate assay of mitochondrial complex III activity. Clin Chim Acta 395, 38-41. IF 2.85
52. Long J, Liu C, Sun L, Gao H, Liu J (2008) Neuronal Mitochondrial Toxicity of Malondialdehyde: Inhibitory Effects on Respiratory Function and Enzyme Activities in Rat Brain Mitochondria.Neurochem Res.IF 2.1
53. Shen H, Zhang Y, Xu J, Long J, Qin H, Liu F, Guo J (2007) Zinc distribution and expression pattern of ZnT3 in mouse brain. Biol Trace Elem Res 119, 166-174. IF 1.5
54. Long J, Wang X, Gao H, Liu Z, Liu C, Miao M, Cui X, Packer L, Liu J (2007) D-galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid. Biogerontology 8, 373-381. IF 3.0
55. Liu Z, Sun L, Zhu L, Jia X, Li X, Jia H, Wang Y, Weber P, Long J, Liu J (2007) Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction. J Neurochem 103, 2690-2700.IF 4.1
56. Sun L, Luo C, Long J, Wei D, Liu J (2006) Acrolein is a mitochondrial toxin: effects on respiratory function and enzyme activities in isolated rat liver mitochondria. Mitochondrion 6, 136-142. IF 3.7
57. Luo C, Wang X, Long J, Liu J (2006) An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates. J Biochem Biophys Methods 68, 101-111. IF 2.2
58. Long J, Wang X, Gao H, Liu Z, Liu C, Miao M, Liu J (2006) Malonaldehyde acts as a mitochondrial toxin: Inhibitory effects on respiratory function and enzyme activities in isolated rat liver mitochondria. Life Sci 79, 1466-1472. IF 2.5
59. Cui X, Zuo P, Zhang Q, Li X, Hu Y, Long J, Packer L, Liu J (2006) Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. J Neurosci Res 83, 1584-1590. IF 2.9