Dr. Kyu-Jae Lee, M.D., PhD., (Wonju College of Medicine, Yonsei University)

Senior Advisor


About 17 years ago (1990's) I began studying alkaline ionized water and published scientific articles on its antioxidant, anticancer, and anti-diabetic effects, but did not really understand why the water worked. It was difficult to believe. Upon further investigation I have now confirmed that the benefits from the alkaline ionized water are attributed to the hydrogen gas produced during electrolysis. The more I research and learn about hydrogen the more dedicated and passionate I become in educating and helping others.

Career Summary

1987-1993 M.B. Medical Science, Wonju College of Medicine, Yonsei University, Wonju, Korea
1995-1998 Ph.D. Department of Parasitology, Graduate School of Wong Wang College of Medicine, Iksan, Korea
1993-1995 M.P.H. Department of Medicine, Graduate School of Yonsei University, Seoul, Korea
2001-2005 Instructor, Department of Parasitology, Wonju College of Medicine, Yonsei University
2005 -2008 Assistant Professor, Department of Parasitology, Wonju College of Medicine, Yonsei University
2008-2013 Associate Professor, Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University
2008 – present Head Professor, Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University
2010-present Senior Research Fellow, Institute for Poverty Alleviation and International Development (IPAID), Yonsei University
2010 – present President of The Korean Water Society
2013- present Full Professor, Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University
2011– 2013 Project Manager of the Project “Health Services Improvement in Tikapur”. KOICA, Yonsei University & Ministry of Health and Population of Nepal
2014–present Director of Roseclub International (Korean NGO)

Selected articles

No Title Journal Year Grade
1 Immunotoxicity of silicon dioxide nanoparticles with different sizes and electrostatic charge Int J Nanomed 2014 SCIE
2 positive effects of hydrogen water on 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice Biol Pharm Bull 2014 SCIE
3 Validity of SW982 synovial cell line for studying the drugs against rheumatoid arthritis in fluvastatin-induced apoptosis signaling model Indian J Med Res 2014 SCIE
4 The drinking effect of Gangcheon mountain spring water on diabetes patients Korean J Waters 2014
5 The Biological effects of Long-term drinking Gangcheon mountain spring water on ICR mouse Korean J Waters 2014
6 Changing Pattern of Complementary and Alternative Medicine in Tikapur Nepal: A Hope for Future Health Altern Integ Med 2014
7 The drinking effect of hydrogen water on atopic dermatitis induced by dermatophagoides farinae allergen in NC/Nga mice Evid-Based Comp Alt 2013 SCIE
8 The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice Mol Cell Toxicol 2013 SCIE
9 CpG oligodeoxynucleotide induces apoptosis and cell cycle arrest in A20 lymphoma cells via TLR9-mediated pathways Mol Immunol 2013 SCI
10 HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and
regulating Akt, Erk and p38 signals via suppression of mevalonate pathway
Cell Death Disease 2013 SCI
11 Assessment of drinking water and sanitation habits in rural Tikapur, Nepal Rural Remote Health 2013 SSCI
12 Anti-obesity effect of alkaline reduced water in high fat-fed obese mice Biol Pharm Bull 2013 SCIE
13 Autophagy contributes to apoptosis in A20 and EL4 lymphoma cells treated with fluvastatin Cancer Cell Int 2013 SCIE
14 Involvement of the FoxO3a pathway in the ischemia/ reperfusion injury of cardiac microvascular endothelial cells Exp Mol Pathol 2013 SCIE
15 clinical effect and mechanism of alkaline reduced water J Food Drug Anal 2012 SCI
16 Application of electrolyzed water as a useful disinfectant in developing countries Korean J Waters 2012 SCIE
17 evaluation of the efficiency of the urine-mda analyzer compared to TBARS malondialdehyde quantitation Korean J Waters 2012
18 The anti-oxidant effect of high concentrated mineral water: in vivo and in vitro Korean J Waters 2012
19 Tube well contamination in Tikapur, Nepal Korean J Waters 2012
20 Bambusae caulis in Liquamen suppresses the
expression of thymus and activation-regulated chemokine and macrophage-derived chemokine in human keratinocytes due to antioxidant effect
Evid-Based Comp Alt 2012 SCI
21 Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless mice Biol Pharm Bull 2011 SCIE
22 The melamine excretion effect of the electrolyzed reduced water in melamine-fed mice Food Chem Toxicol 2011 SCI
23 The effect of extract powder of fruits and vegetables on hangover Korean J Waters 2011
24 The effects of hot spring water on reactive oxygen species (ROS) in human study Korean J Waters 2011
25 The bathing effect of mineral-deep water on DNCB-induced atopic dermatitis-like skin lesions in hairless mice Korean J Waters 2011
26 The effect of obesity inhibition on drinking of Makgeolli made by alkaline spring water in high fat diet-fed C57BL/6 mice Korean J Waters 2011
27 The water quality evaluation of hot spring water of Gangcheon-san, Sunchang-gun, Korea Korean J Waters 2011
28 The evaluation of efficacy on oral cavity cleaner (Dental Cleaner) Korean J Waters 2011
29 Alkaline reduced water and its antioxidant effect Korean J Waters 2011
30 Involvement of oxidative stress in simvastatin-induced apoptosis of murine CT26 colon carcinoma cells Toxicol Letters 2010 SCI
31 Reactive oxygen species are involved in the IFN-r-stimulated production of Th2 chemokines in HaCaT keratinocytes J Cell Physiol 2010 SCI
32 Alkaline reduced water Korean J Waters 2010
33 The effects of alkaline reduced water on hangover symptom Korean J Waters 2010
34 The effects of bath in alkaline reduced spring water on reactive oxygen species (ROS) in human study Korean J Waters 2010
35 The effect of mineral induced alkaline reduced water on broiler chicken Korean J Waters 2010
36 The efficacy of evaluation of tourmaline-ionized water in animal study Korean J Waters 2009
37 Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats Biomed Res 2009
38 Essential involvement of cross-talk between IFN-randTNF-a in CXCL10 production in human THP-1 monocytes Korean J. Microscopy 2009
39 Fluvastatin inhibits expression of the chemokine MDC/CCL22 induced by interferon-?in HaCaT cells, a human keratinocyte cell line Biomed Res -Tokyo 2009 SCIE
40 Effects of Bambusae caulis in Liquamen on the development of atopic dermatitis-like skin lesions in hairless mice J Cell Physiol 2009 SCI
41 The adenylylcyclase-cAMP system suppresses TARC/CCL17 and MDC/CCL22 production through p38 MAPK and NF-kB in HaCaT ke43ratinocytes Brit J Pharmacol 2009 SCI
42 The Food Safety of Superfine Powder (Phellinus linteus) Processed by Nanomill in C57BL/6 Mice J Ethnopharmacol 2009 SCIE
43 The Anticancer Effect of Inonotus obliquus Pilat(Chaga) Processed by Nanomill Technology In Vivo Mol Immunol 2009 SCI
44 Superfine saengshik improves the liver protecting effect compared with fine Saengshik in animal model Korean J. Microscopy 2009
45 The food safety of superfine Saengshik processed by top-down technique in mice Korean J. Microscopy 2009
46 the immunological effects of electrolyzed reduced water on the Echinostoma hortense infection in C57BL/6 mice J Food Sci 2009 SCIE
47 The effects of electrolyzed reduced water on blood
and organ tissues of mice
Korean J Microscopy 2008
48 The effects of magnesium rich sea mineral water on atopic dermatitis-like skin lesions in hairless mice Korean J. Microscopy 2008
49 The effect of mineral-induced alkaline reduced water on the DSS-induced acute inflammatory
bowel disease mouse model
Korean J. Microscopy 2008
50 Anticancer effect of ascorbic acid and saengshik
on CT-26 colon cancer
Korean J. Microscopy 2008
51 Effects of electrolyzed alkaline reduced water
on Echinostoma hortense infection and immune response in C57BL/6 mice
Korean J. Microscopy 2008
52 Ultramicroscopic investigation of the preservation status of hair collected from a full-term, intrauterine baby mummy of the Joseon Dynasty, Korea Int J Osteoarchaeol 2008 SSCI
53 Immune response and inhibitory effect of ketotifen on the BALB/c and C3H/HeN mice infected with Echinostoma hortense Korean J. Microscopy 2007 SCIE
54 A clinical trial of orally administered alkaline reduced water J Exp Biomed 2007 SCIE
55 The effects of Saengshik on the hepatotoxicity of mouse induced by carbon tetrachloride Korean J. Microscopy 2007
56 Differential immune profiles following experimental Echinostoma hortense infection in BALB/c and C3H/HeN mice Parasitol Res 2007 SCIE
57 The liver protecting effect of pomegranate (Punica granatum) seed oil in mice treated with CCl4 Korean J. Microscopy 2006
58 Survey report on understanding the safety and efficacy of alkaline reduced water Newest Med 2006
59 Anti-diabetic effect of alkaline-reduced water on OLETF rats Biosci Biotechnol Biochem 2006 SCIE
60 The study on the safety of alkaline reduced water for drinking in the ICR mice Newest Med 2005
61 Reaction of mast cells and goblet cells in the small intestine of C57BL/6 and C3H/HeN mice infected with Echinostoma hortense J Exp Biomed Sci 2005 SCIE
62 The effect of high-salted mineral water on blood pressure and sodium excretion J Exp Biomed Sci 2005 SCIE
63 The effects of green tea and magnessium on type 1 diabetes and liver toxicity in mice Newest Med 2005
64 Anticancer effect of alkaline reduced water J Int Soc Life info Sci 2004
65 The glutathione S-tranferase activity of alkaline reduced water on sprague-dawley rats Newest Med 2004
66 Effect of alkali reduced water (ARW) on the lipid metabolism of ICR mice Newest Med 2004
67 The change of pH and oxidation-reduction potential (ORP) of alkaline reduced water Newest Med 2004
68 Reactive oxygen species (ROS) scavenging effect of alkaline-reduced water Newest Med 2004