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Dr. Jianming Cai, M.D., PhD.

Senior Advisor

 

“More hydrogen, Better Life”

EDUCATION HISTORY

1992-1995 Ph.D Department of Radiation Medicine, Third Military Medical University. Majored in Prevention Medicine, Supervisor: Prof. Tianming Cheng & Prof. Chengji Luo.
1986-1989 M.S. Department of Radiation Medicine, Second Military Medical University. M.A. in Radiation Medicine. Advisor: Dr. Zhiguang Mai.
1979-1984 B.S. Undergraduate Management Unit, Second Military Medical University.
B.A. in Clinical Medicine.

PROFESSIONAL EXPERIENCE

2010- Professor, Ph.D supervisor, leading scholar in National Key Discipline Radiation Medicine. Chair of the Key Laboratory, Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University.
2000-2009 Professor, Ph.D supervisor, Dean of the Faculty of Naval Medicine, Second Military Medical University and leading scholar in Radiation Medicine and Nautical Medicine in our university.
1998-2000 Professor, Ph.D supervisor, Chair of the Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University.
1993-1998 Associate professor and Master’s supervisor in the Department of Radiation Medicine at
Second Military Medical University.
1986-1993 Instructor in the Department of Radiation Medicine at Second Military Medical University. 1984-1986 Teaching assistant in the Department of Radiation Medicine at Second Military Medical
University.

RECENT RESEARCH FUNDS

2012 National Natural Science Foundation of China. Name: The radioprotective effects of molecular hydrogen and its underlying mechanism.
2010 The National Basic Research Program of China (973)’s Project. Name: The biological effects of heavy ion particles irradiation on cultured cells.
2010 National Natural Science Foundation of China. Name: The role of TLR4 signaling pathway in radiobiological effects and it mechanism.
2009 National Natural Science Foundation of China. Name: The effects of gamma-irradiation on murine dendritic cells and its mechanism.
2008 National Natural Science Foundation of China. Name: The radioprotective effects of carboxylfullenrence C3 and the underlying mechanism.

PROFESSIONAL ORGANIZATIONS

Executive Council Member of the Biophysical Society of China.
Chairman of the Radiation and Environment Branch Specialized Committee of the Biophysical Society of China.
Vice president of the Biophysical Society of Shanghai.
Chairman of the Radiation Medicine Branch Specialized Committee of the Nuclear Society of Shanghai.

RESEARCH INTERESTS

Radioprotection and therapy of acute and chronic radiation sicknesses.
Radiation induced DNA damage and repair and its underlying mechanism.
Radiation effects on the immune system and the roles in radiation sickness.

PUBLICATIONS (recent four years)

  1. C Liu?F Gao?B Li?REJ Mitchel?X Liu?J Lin?L Zhao and J Cai. TLR4 knockout protects mice from radiation-induced thymic lymphoma by downregulation of IL6 and miR-21. Leukemia; 2011;25,1516-1519 (IF: 8.966).
  2. Chuai Y, Gao F, Li B, Zhao L, Qian L, Cao F, Wang L, Sun X, Cui J, Cai J. Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals. Biochem J ; 2012;442(1):49-56 (IF: 5.016).
  3. Cui J, Cheng Y, Yang Y, Sun M, Gao F, Liu C, Cai J. Down Regulation of miR200c Promotes
  4. Radiation-Induced Thymic Lymphoma by Targeting BMI1. J Cell Biochem. 2013 Dec 25. doi: 10.1002/jcb.24754. [Epub ahead of print]
  5. Qian L, Shen J, Chuai Y, Cai J. Hydrogen as a new class of radioprotective agent. Int J Biol Sci. 2013 9(9): 887-894.
  6. Zhao S, Mei K, Qian L, Yang Y, Liu W, Huang Y, Zhang C, Sun X, Liu C, Li B, Gao F, Cai J, Ni J.. Therapeutic effects of hydrogen-rich solution on aplastic anemia in vivo. Cellular Physiology and Biochemistry. 2013 32:549-60.
  7. Li B, Sun M, Gao F, Liu W, Yang Y, Liu H, Cheng Y, Liu C, Cai J. Up-Regulated Expression of miR-23a/b Targeted the Pro-Apoptotic Fas in Radiation-Induced thymic Lymphoma. Cellular Physiology and Biochemistry. 2013, 2013;32(6):1729-40.
  8. Li B, Zhang C, He F, Liu W, Yang Y, Liu H, Liu X, Wang J, Zhang L, Deng B, Gao F, Cui J, Liu C, Cai J.
  9. GSK-3? Inhibition Attenuates LPS-Induced Death but Aggravates Radiation-Induced Death via Down-Regulation of IL-6. Cell Physiol Biochem. 2013;32(6):1720-8.
  10. Liu H, Huang Y, Zhang W, Sha Z, Li B, Yang Y, Liu W, Zhang C, Gao F, Cai J. Short-Term Hyperosmolality Pretreatment on Cells Can Reduce the Radiosensitivity via RVI and Akt1 Activation. Cell Physiol Biochem. 2013;32(5):1487-96.
  11. Yang Y, Cui J, Gao F, Li B, Liu C, Zhang P, Huang Y, Liu W, Liu H, Cai J. Whole body irradiation induces cutaneous dendritic cells depletion via NF-?B activation. Cell Physiol Biochem. 2013;32(1):200-9.
  12. Yang Y, Gao F, Zhang H, Hunag Y, Zhang P, Liu C, Li B, Cai J. Molecular hydrogen protects human lymphocyte AHH-1 cells against (12)C(6+) heavy ion radiation. Int J Radiat Biol. 2013 Dec;89(12):1003-8.
  13. Qian L, Mei K, Shen J, Cai J. Administration of hydrogen-rich saline protects mice from lethal acute graft-versus-host disease (aGVHD). Transplantation. 2013 Mar 15;95(5):658-62.
  14. Mei K, Zhao S, Qian L, Li B, Ni J, Cai J. Hydrogen protects rats from dermatitis caused by local radiation. J Dermatolog Treat. 2014 Apr;25(2):182-8.
  15. Lin J, Liu C, Gao F, Mitchel RE, Zhao L, Yang Y, Lei J, Cai J. miR-200c enhances radiosensitivity of human breast cancer cells. J Cell Biochem. 2013 Mar;114(3):606-15.
  16. Qian L, Shen J, Cai J. Hydrogen therapy may be an effective and specific novel treatment for aplastic anemia. Med Sci Monit. 2012 Jun;18(6):HY19-22.
  17. Chuai Y, Qian L, Sun X, Cai J. Molecular hydrogen and radiation protection. Free Radic Res. 2012 Sep;46(9):1061-7.
  18. Yang Y, Li B, Liu C, Chuai Y, Lei J, Gao F, Cui J, Sun D, Cheng Y, Zhou C, Cai J. Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis. Med Sci Monit. 2012 Apr;18(4):BR144-8.
  19. Lei J, Zhou C, Hu H, Hu L, Zhao M, Yang Y, Chuai Y, Ni J, Cai J. Mangiferin aglycone attenuates radiation-induced damage on human intestinal epithelial cells. J Cell Biochem. 2012 Aug;113(8):2633-42.
  20. Cong Liu,Bailong LI,Ying Cheng,Jing Lin,Jun Hao,Shuyu Zhang, REJ Mitchel?,Ding Sun,Jin Mi,Luqian
  21. Zhao,Fu Gao,Jianming Cai. MiR-21 plays an Important Role in Radiation Induced Carcinogenesis in BALB/c Mice by Directly Targeting the Tumor Suppressor Gene Big-h3. Int J Biol Sci 2011; 7:347-363 (IF: 3.215)
  22. Liu C, Zhou C, Gao F, Cai S, Zhang C, Zhao L, Zhao F, Cao F, Lin J, Yang Y, Ni J, Jia J, Wu W, Zhou L, Cui J, Zhang W, Li B, Cai J. MiR-34a in Age and Tissue Related Radio-Sensitivity and Serum miR-34a as a Novel Indicator of Radiation Injury. Int J Biol Sci 2011; 7:221-233 (IF?3.215)
  23. Liu C, Lin J, Zhao L, Yang Y, Gao F, Li B, Cui J, Cai J. Gamma-ray Irradiation Impairs Dendritic Cell
  24. Migration to CCL19 by Down-regulation of CCR7 and Induction of Cell Apoptosis. Int J Biol Sci 2011; 7:168-179 (IF?3.215)
  25. Luqian Zhao,Chuanfeng Zhou,Jian Zhang, Fu Gao, Bailong LI,Yunhai Chuai, Cong Liu, Jianming Cai. Hydrogen Protects Mice from Radiation induced Thymic Lymphoma in BALB/c mice. Int J Biol Sci 2011; 7:297-230. (IF?3.215)
  26. Chao ZHANG, Jin NI, Fu GAO, Ding SUN, ChuanFeng ZHOU, Ying Cheng, Cong LIU, JianMing CAI and BaiLong LI. The Mechanism for the Ameliorative Effect of CpG-Oligodeoxy- nucleotides on Bone Marrow Hemopoiesis Radiation Injury. Basic & Clinical Pharmacology & Toxicology. 2011;109:11-16. (IF?2.30)
  27. Zhang C,Lin J,Cui J,Li B, Wang J,Gao F, Cai J.Radioprotection of bone marrow hematopoiesis byCpG-oligodeoxynucleotides administered to mice after total-body irradiation. J Radiat Res;2011;52(6):828-33 (IF?2.077)
  28. LIREN QIAN, FEI CAO, JIANGUO CUI, YUECHENG HUANG, XIAOJIAN ZHOU,SHULIN LIU &
  29. JIANMING CAI. Radioprotective effect of hydrogen in cultured cells and mice. Free Radical Research 2010; 44(3):275-282 (IF?2.215)
  30. Liren QIAN, Fei CAO, Jianguo CUI, Yicun WANG,Yuecheng HUANG, Yunhai CHUAI, Luqian ZAHO,Hao JIANG and Jianming CAI. The Potential Cardioprotective Effects of Hydrogenin Irradiated Mice. J Radiat Res 2010,51(6):741-747. (IF?2.034)
  31. Chuai Y, Shen J, Qian L, Wang Y, Huang Y, Gao F, Cui J, Ni J, Zhao L, Liu S, Sun X, Li B, Cai J. Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice. Med Sci Monit. 2012;18:BR89-94. (IF?1.699)
  32. Chuai Y,Zhao L, Ni J,Sun D,Cui J, LI B,Qian L,Gao F,Cai J. A possible prevention strategy of radiation pneumonitis: Combine radiotherpy with aerosol inhalation of hydrogen-rich solution. Med Sci Monit, 2011;17;hy1-4 (IF?1.699)
  33. Cong Liu, Jianguo Cui, Quan Sun, Jianming Cai?Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome. Medical Hypotheses. 2010.1,145?146. (SCI, IF?1.319)
  34. Liren Qian, Bailong Li, Fei Cao, Yuecheng Huang, Shulin Liu, Jianming Cai, Fu Gao. Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage; Nuclear Technology & Radiation Protection,2010, 25(1):23-29 (IF?0.718)
  35. Liren Qian, Bailong Li, Fu Gao, Jianming Cai.The Hypothesis of an Effective, Safe and Novel Radioprotective Agent:Hydrogen-rich Solution; West Indian Med J,2010,59?2??122-126. (IF?0.338)